DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4757 and ache

DIOPT Version :9

Sequence 1:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	585	Identity:	178/585 - (30%)
Similarity:	267/585 - (45%)	Gaps:	95/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVLLASSSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPK 73
            |||...:.|...:.|.|..|:|||.. ...|..:..||.||.:||||:..:||...:|.|||: .
Frog    17 LLVPALTQSDGGLLVSTRSGKVRGLR-QPVLSTHVSAFLGIPFAEPPVDKMRFRRSEPKKPWT-D 79

  Fly    74 IFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLKGRRP----VIVFLHPG 121
            ::||:.....|.|             .|:....:|||||.||::   :...||    |:|:::.|
Frog    80 VWDATAYPNACYQYFDTLYPGFPGMEMWNPNRPMSEDCLYLNIW---VPHPRPSNATVMVWIYGG 141

  Fly   122 GFYVFSGQS-------KYLAGPEHFMDRDCVLVSLNYRLGSLGF--LATGSKEAPGNAGLKDQVL 177
            |||  ||.|       :||...|     :.::||:|||:|:.||  |..||.:||||.||.||.|
Frog   142 GFY--SGSSSLDVYDGRYLCHAE-----NVIVVSMNYRVGAFGFLTLTPGSVDAPGNVGLFDQRL 199

  Fly   178 ALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDL 242
            ||:|:|.:|..|||||.:||:.|.|||::||.:|:|||.|..||.:....|.:|..|  :.....
Frog   200 ALQWVQDNIAFFGGDPRTVTIFGESAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTP--WATITP 262

  Fly   243 QLAKRQAGL----LKCPQESIGEMVECMRRK---PYLDY---VSTYNGMFEFGWNPVLNWRIVVE 297
            |.|:|:..|    |.|...:..|::.|:|.|   ..:|:   |.....:|.|.:.|      |.:
Frog   263 QEARRRTELLGKFLDCRMGNDTELLNCLRVKQPQELIDHEFSVLPAPSVFRFAFVP------VPD 321

  Fly   298 KDFGQERYLIESPFKTARRGDFHKVALITGITEFE----FLSGA-FFDLRNESIVNRYNRDWEHY 357
            .||     ..|.|......|.|....||.|:.:.|    .|.|| .|...|||::.|.    |..
Frog   322 ADF-----FPEPPEILMNMGRFKPCPLIMGVNQNEGSYFLLYGAPGFSKNNESLITRE----EFL 377

  Fly   358 ASIALLLEQNSTQSRAASRVFREKYMPESLDKLEY---PKSLKGMGELLSDALIGVSFHRFL-QL 418
            ..:.:.:.|       |:.:..|..:.:..|..:.   .|:.:.|.:|:.|..:......|. ::
Frog   378 GGVKMSVPQ-------ANDIALEAVVMQYTDWADEHAGVKNREAMDQLVGDHNVICPLTYFAGKV 435

  Fly   419 MSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPL---LKREDPENFMIE 480
            ......:|||.|.::.     .|....|.:|..|..|:.::|  ||  ||   |.....|..:..
Frog   436 AETGNRVYTYFFDHRA-----SNLAWPQWMGVPHGYEIEFVF--GL--PLDANLNYTPQEEALSR 491

  Fly   481 LLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIGNNLTAKSGGFFLNRYQIWEDLFP 545
            .:.|.|..||:.|||:..||.:..  .||||.|.::.|:.:.|....:..|..:.....|....|
Frog   492 RMMRYWANFARTGDPNEGNDAHQP--RWPLYTASEQRYMALNNKPYQELQGIRVQTCMFWNRFLP 554

Fly 546 545
Frog 555 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	173/572 (30%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	74/189 (39%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	172/564 (30%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910