DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and ACO2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_012335.1	Gene:	ACO2 / 853230	SGDID:	S000003736	Length:	789	Species:	Saccharomyces cerevisiae

Alignment Length:	771	Identity:	416/771 - (53%)
Similarity:	536/771 - (69%)	Gaps:	27/771 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKG-RLGGPLTLSEKVLYSHLDQPD----SQE 79
            |...||...|    ||.|.:| ||.||..|||.||. ....||||:||:|||||..|:    |.:
Yeast    17 HANMFPSVSK----NFQTKVP-PYAKLLTNLDKIKQITNNAPLTLAEKILYSHLCDPEESITSSD 76

  Fly    80 IE--RGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIEAQISGDKDLARAK 142
            :.  ||..||:|.|||||:|||:|||.||||:::||.:.:||:::||||||..:....|||..:.
Yeast    77 LSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSI 141

  Fly   143 DLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGCLCVGVG 207
            ..|:||:|||.|...:|.:.||.|||||||||:|||::.|||:|:||||||||.||||.:.:|||
Yeast   142 ATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVG 206

  Fly   208 GADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVES 272
            ||||||.:...|||||.|.::|..||||::||::|||||.|:|.:|||:||||.||||.|.||.:
Yeast   207 GADAVDALTGTPWELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVST 271

  Fly   273 ISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEA--TKNK-DLLVPDEGCKYDK 334
            :||||||||.|||||||||||.||:.|....||:||.|..:|:.|  ..|| :.|..|:..:|||
Yeast   272 LSCTGMATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDK 336

  Fly   335 VIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYEDMGRCASIAN 399
            ||||:|..:||.|||||||||:.|||:..:.|.|..:|.::...||||||||||:||.|...:..
Yeast   337 VIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVK 401

  Fly   400 DALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMGEK- 463
            .|...|||..:||.|||||||:|||:.||||||:.::.|..|||||||||||||:|:||....|
Yeast   402 QASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKE 466

  Fly   464 -NTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKTFKLKEPHG 527
             |||.||:||||..|||.|..|..|:||||:.||::.:|...|||:||.:...:||.||.:.|.|
Yeast   467 TNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKG 531

  Fly   528 EELPSKGFDPGEDTY--QAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKC 590
            :|||.:||:.|.|.:  :..|....::::.|||.||||||||||:.|:||: :...||:|::|||
Yeast   532 DELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKE-LKTNVLLKVEGKC 595

  Fly   591 TTDHISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYKANKIKW 655
            |||||||||.||||:|||:|||.|..|||.|.|..|:||..:.....:| :|.:...:|::...|
Yeast   596 TTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYD-IPGLMMKWKSDGRPW 659

  Fly   656 CAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSS 720
            ..:.|.||||||:||||||.||.|||..::||||||||||||||||:|.|||||..||||:....
Yeast   660 TVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGD 724

  Fly   721 KISILNLKDLAP-----GKPVDAEI-KNNGSSDKIQLNHTLNELQIQWFQAGSALN 770
            .:..|||.|:..     |..:|.:| |.||.|..|:..||:::.||.:|:||||:|
Yeast   725 VLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAIN 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	407/748 (54%)
		AcnA_Mitochondrial	93..503	CDD:153134	240/414 (58%)
		Aconitase_swivel	585..733	CDD:294147	84/152 (55%)
ACO2	NP_012335.1	aconitase_mito	35..782	CDD:273561	407/748 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.8533	Normalized mean entropy	S129
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	O	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.720