DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and LYS4

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_010520.3	Gene:	LYS4 / 851820	SGDID:	S000002642	Length:	693	Species:	Saccharomyces cerevisiae

Alignment Length:	821	Identity:	182/821 - (22%)
Similarity:	315/821 - (38%)	Gaps:	196/821 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SMVRNFHTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSH-LDQPDS 77
            :..|:||::|                           ..:||:     .|:||::.|: ::.|:.
Yeast     6 TFTRSFHSSR---------------------------AWLKGQ-----NLTEKIVQSYAVNLPEG 38

  Fly    78 QEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTV--HCDHLIEAQISGDKDLAR 140
            :.:..| .|:.::|......| .:....|:|:..|..|:..||.:  ..||  :.|...:|:|.:
Yeast    39 KVVHSG-DYVSIKPAHCMSHD-NSWPVALKFMGLGATKIKNPSQIVTTLDH--DIQNKSEKNLTK 99

  Fly   141 AKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIIL-ENYAFPGLLMIGTDSHTPNGGGLGCLCV 204
            .|:        :.:...|:::..:..|.||.|||:: |.||||..:.:.:|||:...||||.|..
Yeast   100 YKN--------IENFAKKHHIDHYPAGRGIGHQIMIEEGYAFPLNMTVASDSHSNTYGGLGSLGT 156

  Fly   205 GVGGADAVDVMA--NIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHG 267
            .:...||..:.|  ...|::  |.|....|.|::....|.||:|:.:..:..........:|:.|
Yeast   157 PIVRTDAAAIWATGQTWWQI--PPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTG 219

  Fly   268 PGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATKNKDLLVP------ 326
            ..:.::......||.||..|.||.:.:||.::.::.:.    :..:....|.|...:.|
Yeast   220 DSLNALPIDHRLTIANMTTEWGALSGLFPVDKTLIDWY----KNRLQKLGTNNHPRINPKTIRAL 280

  Fly   327 ---------DEGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGS 382
                     |:...|.|.:.|:|.||...|:||.:..:::.:..|.|..      ::|..:.:.|
Yeast   281 EEKAKIPKADKDAHYAKKLIIDLATLTHYVSGPNSVKVSNTVQDLSQQD------IKINKAYLVS 339

  Fly   383 CTNSSYEDMGRCASIANDALGHGLKSC--------------VPFNVTPGSEQVRATIARDGIIDV 433
            ||||...|:...|.:.          |              |.|.|...|.::.|...:.|..:.
Yeast   340 CTNSRLSDLQSAADVV----------CPTGDLNKVNKVAPGVEFYVAAASSEIEADARKSGAWEK 394

  Fly   434 LEKFGGTVLANACGPCIGQWDRKDVKMG----EKNTI-VTSYNRNFTGRNDANPATHCFVTSPEM 493
            |.|.|...|.:.||||||        :|    |...: :::.||||.||..:..|. .::.||.:
Yeast   395 LLKAGCIPLPSGCGPCIG--------LGAGLLEPGEVGISATNRNFKGRMGSKDAL-AYLASPAV 450

  Fly   494 ATALAIAGRLDFNP----MTDELTGTDGKTFKLKEPHGEELPSKGFDPGEDTYQAPPAKADDIKV 554
            ..|.|:.|::. :|    .|.|:..:..||..::.|..||                     ::..
Yeast   451 VAASAVLGKIS-SPAEVLSTSEIPFSGVKTEIIENPVVEE---------------------EVNA 493

  Fly   555 NVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGA 619
            ..:.....:::||.|.    :::...:||      |..|:|:..|.:.....:.|::.... :..
Yeast   494 QTEAPKQSVEILEGFP----REFSGELVL------CDADNINTDGIYPGKYTYQDDVPKEK-MAQ 547

  Fly   620 TNAENNEMNKVKNQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAI 684
            ...||.:.........|..                  .|...|:|.|||||.||......|...:
Yeast   548 VCMENYDAEFRTKVHPGDI------------------VVSGFNFGTGSSREQAATALLAKGINLV 594

  Fly   685 IVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSKISILNLK---------DLAPGKPVDAEI 740
            :..||..|...|.....:|.|..  |....|::...:.:...|.         |:|..|.|..|
Yeast   595 VSGSFGNIFSRNSINNALLTLEI--PALIKKLREKYQGAPKELTRRTGWFLKWDVADAKVVVTE- 656

  Fly   741 KNNGSSD-KIQLNHTLNELQIQWFQAGSALNLMKELAAKGG 780
               ||.| .:.|...:.||         ..|| :|:..|||
Yeast   657 ---GSLDGPVILEQKVGEL---------GKNL-QEIIVKGG 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	173/782 (22%)
		AcnA_Mitochondrial	93..503	CDD:153134	110/448 (25%)
		Aconitase_swivel	585..733	CDD:294147	30/156 (19%)
LYS4	NP_010520.3	h_aconitase	20..693	CDD:129245	177/780 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.8533	Normalized mean entropy	S129
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.720