DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and ireb2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_012822208.1	Gene:	ireb2 / 780221	XenbaseID:	XB-GENE-943197	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	990	Identity:	230/990 - (23%)
Similarity:	377/990 - (38%)	Gaps:	260/990 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQRTHRYIC--LAGSMVRNFHTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTL 63
            |.:....|:.  |:|:..:.|...     .|:..:.:|:   |||        ||:..|...:..
Frog    28 MTENPFHYLVEPLSGTSDKTFFNV-----SKLKATEYDS---LPY--------CIRVVLEAVVRN 76

  Fly    64 SEKVLYSHLDQPDSQEIERGKSYLRLR-----PDRVALQDATAQMTLLQF--ISSGLKKV----- 116
            .:.||   :.:.|:..|...|:....:     |.||.|||.|....::.|  :...:.|.
Frog    77 CDGVL---VKEQDAFNILNWKATCEFKEIPFLPARVMLQDFTGIPAMVDFAAMRDAISKFGRDPK 138

  Fly   117 ----AVPSTVHCDHLIEAQI------------------------SGDKDLAR------------- 140
                |.|:.:..||.::...                        |..|.|.|
Frog   139 QVNPACPTDLIADHSLQLDFTKCIVAQNVSSVPTVETHKPTTKQSPGKTLGRKAQCRSQSGCKGA 203

  Fly   141 ----------------------------------AKDL------NKEVYDFLSSACAK--YNLGF 163
                                              .|.|      |||...|. ..|.|  :|:..
Frog   204 CELGAAHGSSREQIENTPMLCPFHLQPIAEPEAALKSLEIEFNRNKERLQFF-KWCTKAFHNVAV 267

  Fly   164 WKPGSGIIHQIILE----------NYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANI 218
            ..|.:|.:||:.||          .:.:|. .::||||||....|||.|.:||||.::...|..:
Frog   268 IPPETGTVHQVNLEFLSRVVMEEKGFIYPD-SVLGTDSHTTMVNGLGILGLGVGGIESEAAMLGV 331

  Fly   219 PWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITN 283
            |..|..|.||||.|||.|:...:..||:|.:.:.|...|..|..||:.|.||..:|.....||.|
Frog   332 PITLTLPEVIGCELTGAINPLATSIDVVLSITKHLKQAGVAGTFVEFFGNGVSQLSVADRTTIAN 396

  Fly   284 MGAEIGATTSIFPFNERMVTYLRATG---RGAIADEATKNKDLLVPDEGC---KYDKVIEINLDT 342
            |..|.|||.:.||.:...:.:|:.||   :.....|.......|:..|..   :|.||::|||::
Frog   397 MCPEYGATVAFFPVDSVTLRHLKQTGVDVQSVSTFETYLQAVKLLRQENVQQPEYSKVLQINLNS 461

  Fly   343 LEPLVNGPFTPDLAHPISKLGQN-----SEKNG-----------------------YPME---IK 376
            :.|.|:||..|.....:..:.::     :||.|                       |.:.   :.
Frog   462 IVPYVSGPKRPQDRISVMDMKKDFEACLNEKTGLKGFQIPEKKQSIMVPVTYENSEYSLSHGCVV 526

  Fly   377 VSLIGSCTNSSYEDMGRCAS-IANDALGHGL--KSCVPFNVTPGSEQVRATIARDGIIDVLEKFG 438
            ::.:.||||:....:...|. :|..|:..||  |..:..:::|||..|...::..|::..|.|.|
Frog   527 IAAVTSCTNNCNPSVMLTAGLLAKKAVEAGLTVKPYIKTSLSPGSGTVTYYLSASGVLPYLSKLG 591

  Fly   439 GTVLANACGPCIGQWDR------KDVKMGEKNTI-VTSYNRNFTGRNDANPATHCFVTSPEMATA 496
            ..::...|..|:|..:.      ..:|.||.... |.|.|::|.| |..:.....::.||.:..|
Frog   592 FDIIGYGCARCVGNTNPLPESIVTAIKEGELVACGVFSGNKHFEG-NRCSCVCANYLASPPLVVA 655

  Fly   497 LAIAGRLDFNPMTDEL-TGTDGKTFKLKE--PHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDP 558
            .|:||.::.:..|:.| ....|:...|::  |..||:...     |:| ...|:...::|:.::.
Frog   656 YALAGTVNIDLQTEALGENAQGEKIFLRDIWPSREEVLEV-----EET-MVIPSMFSELKLKIEK 714

  Fly   559 KSDRLQLLEPFEK----WDGKDYI---------------------DLMVLIKIKGKCTTDHISAA 598
            ::.|..||:..|.    ||.:...                     ...||:.:....||||:|.|
Frog   715 QNTRWNLLDAPESTLFPWDLRSTFIRSPPFFHKLEKIPPPIQPIEKAHVLLYLGDSVTTDHMSPA 779

  Fly   599 G------PWLKY-------------------------RGHLDNIS-NNMFIGATNAENNEMNKVK 631
            |      |..||                         ||...|:. .|..:|.|..:.  .:...
Frog   780 GSIPRTSPAAKYLIQKNLIPREFNSYGARRGNDAVMTRGTFANMKLFNKLVGKTGPKT--FHLPS 842

  Fly   632 NQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETN 696
            .|....|||    |..|:..:|....:..:.||.|:||:.||..|..||...:|.:|:.:||:.:
Frog   843 GQIMDVFDA----AELYQKAEIPLIIIAGKKYGLGNSRDWAAKGPFLLGVRVVIAESYEKIHKDH 903

  Fly   697 LKKQGMLALTFANPGDYDKVQPSSK--ISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTL---- 755
            |...|:..|.|.:..:.:.:..|:|  .|.....||.|...:  |:|.|..    :..|.:
Frog   904 LVGMGIAPLQFLSGENAETLGLSAKEQYSFSLPVDLTPRHKI--EVKTNTG----KTFHVIAAFD 962

  Fly   756 NELQIQWFQAGSALN 770
            ||.::.:::.|..|:
Frog   963 NEAEVTFYKHGGILS 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	221/946 (23%)
		AcnA_Mitochondrial	93..503	CDD:153134	137/556 (25%)
		Aconitase_swivel	585..733	CDD:294147	46/181 (25%)
ireb2	XP_012822208.1	PTZ00092	25..982	CDD:240263	230/990 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920