DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAcon2 and ireb2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_005163029.1	Gene:	ireb2 / 652982	ZFINID:	ZDB-GENE-051205-1	Length:	974	Species:	Danio rerio

Alignment Length:	796	Identity:	212/796 - (26%)
Similarity:	316/796 - (39%)	Gaps:	184/796 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LKKVAVPSTVHCDHLIEAQISGDKDLARAKDLNKEVYDFLSSACAK--YNLGFWKPGSGIIHQII 175
            |:.|:.|.|     ::..|   :.:|.|    |||...|. ..|:|  .|:....|....:||:.
Zfish   215 LQPVSEPET-----MVRNQ---EMELIR----NKERLQFF-KWCSKSFNNVNVVPPDISTVHQLN 266

  Fly   176 L----------ENYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGC 230
            |          |.:.:|. .::||||||....|||.|..||||.::..||...|..|..|.|:||
Zfish   267 LEYLCKVVQEEEGFIYPD-SVVGTDSHTTMINGLGILGWGVGGIESEAVMLGQPVSLTLPQVVGC 330

  Fly   231 HLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIF 295
            .|.|.|:...:..|::|.:.:.|...|..|..||:.||||..:|.....||.||..|..||.|.|
Zfish   331 KLVGTINPLATSIDIVLGITKHLRQAGIGGKFVEFFGPGVPQLSAPDRTTIANMCPEYNATVSFF 395

  Fly   296 PFNERMVTYLRATGRGAIADEATKNKDLLVPD---------------EGCKYDKVIEINLDTLEP 345
            |.::..:.:.:.|    |..|   .|.|::.|               |..:|.:|||:||.::.|
Zfish   396 PVDDITLQHFKHT----ICSE---EKLLVLEDYLKAVKLFRSYDDQSEEPQYSEVIEMNLSSIVP 453

  Fly   346 LVNGPFTPDLAHPISKLGQN-----SEKNGY--------------PM------------EIKVSL 379
            .|:||..|.....|:.:.::     :||.|:              |.            .:.::.
Zfish   454 HVSGPKRPQDRVAITGMKEDFISCLNEKVGFKGFHISKEKQSTLVPFRHDGAEYNLAHGSVVIAA 518

  Fly   380 IGSCTNSSYEDMGRCAS-IANDALGHGL--KSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTV 441
            :.||||:....:...|. :|..|:..||  |..:..::.|||..|...:...|::..|:|.|..|
Zfish   519 VISCTNNCNPSVMLAAGLLAKKAVEAGLTVKPYIRTSLVPGSGTVTHYLNTSGVLPFLKKLGFEV 583

  Fly   442 LANACGPCIGQW--------DRKDVKMGEKNTI-VTSYNRNFTGRNDANPATHC----FVTSPEM 493
            :...|..|:|..        |.  ||.|:.... |.|.||:..||     ...|    ::.||.:
Zfish   584 VGYGCATCVGNTAPLPESVVDA--VKQGDLVACGVLSGNRHLEGR-----LCDCVRANYLASPPL 641

  Fly   494 ATALAIAGRLDFNPMTDEL-TGTDGKTFKL------KEP--HGE----------ELPSKGFDPGE 539
            ..|.||||.:..|..|:.| ...|||...|      ||.  |.|          ||.|: .:.|.
Zfish   642 VVAYAIAGTVSINLETEPLGVNADGKDVFLCDIWPTKEEVNHIEENIVIASMFTELRSR-MEKGS 705

  Fly   540 DTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKW----------DGKDYIDLMVLIKIKGKCTTDH 594
            ..:....: |:......||||..::....|.|.          ||     ...|:.:..|.||||
Zfish   706 SFWNNLES-AESALFPWDPKSTYIRCPSFFSKMSKEVCSPQSIDG-----AYPLLFLGDKVTTDH 764

  Fly   595 ISAAG------PWLKY-------------------------RGHLDNIS-NNMFIGATNAENNEM 627
            ||.||      ...||                         ||...:|. .|..||.|..
Zfish   765 ISPAGSIARVSAAAKYLQSKRLTPREFNSYGARRGNDAVMTRGTFASIKLQNRLIGKTGP----- 824

  Fly   628 NKVKNQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARI 692
             |..:..||....|...|..|:.:.:....:..:.||.||||:.||..|..||..|:|.:||.:|
Zfish   825 -KTLHIPTGQTLDVFEAAERYQRDGVPLIILAGKEYGSGSSRDWAAKGPYLLGVRAVIAESFEKI 888

  Fly   693 HETNLKKQGMLALTFANPGDYDKVQPSSK--ISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTL 755
            |..:|...|:..|.|....:.|.::...|  .:|    |:........:|....|:.|..:...|
Zfish   889 HRNHLVGMGIAPLQFLPGQNADSLELCGKERFTI----DIPEELTARQQITVQTSTGKSFMVTAL 949

  Fly   756 --NELQIQWFQAGSAL 769
              |::.:::|:.|..|
Zfish   950 FENDMDVEFFRHGGIL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	212/796 (27%)
		AcnA_Mitochondrial	93..503	CDD:153134	130/463 (28%)
		Aconitase_swivel	585..733	CDD:294147	49/181 (27%)
ireb2	XP_005163029.1	PTZ00092	10..973	CDD:240263	212/796 (27%)
		Aconitase	89..651	CDD:294203	130/463 (28%)
		AcnA_IRP_Swivel	755..924	CDD:238812	48/178 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820