DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and Ireb2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_073146.2	Gene:	Ireb2 / 64602	MGIID:	1928268	Length:	963	Species:	Mus musculus

Alignment Length:	975	Identity:	237/975 - (24%)
Similarity:	365/975 - (37%)	Gaps:	265/975 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQPDSQ-EIERGKSY 86
            :|....|:..:.:|.   ||| .:|..|:.......|.|...|.|: :.||....| .:|
Mouse    24 KFFNVPKLGGTKYDI---LPY-SIRVLLEAAVRNCDGFLMKKEDVM-NILDWKTKQSNVE----- 78

  Fly    87 LRLRPDRVALQDATAQMTLLQF---------ISSGLKKV--AVPSTVHCDHLIEAQIS------- 133
            :...|.||.|||.|....::.|         :....|||  |.|:.:..||.::...|
Mouse    79 VPFFPARVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCAIQNA 143

  Fly   134 ---GDKDLARAKDL--------------------------------------------------- 144
               |..||.:|..|
Mouse   144 PNPGGGDLQKAGKLSPLKVQSKKLPCRGQTTCRGSCDSGELSRNSGTFSSQIENTPVLCPFHLQP 208

  Fly   145 -----------------NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILE----------NYAF 181
                             |:|...|.. |:.|..|:....||:|:.||:.||          :..|
Mouse   209 VPEPETVLKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEYLSRVVFEETDLLF 273

  Fly   182 PGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVI 246
            |. .::|||||.....|||.|..||||.:...||..:|..|..|.|:||.|||..:.:.:..|::
Mouse   274 PD-SVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIV 337

  Fly   247 LKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATG-- 309
            |.:.:.|...|..|..||:.|.||..:|.....||.||..|.||..|.||.:...:.:|..||
Mouse   338 LGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFD 402

  Fly   310 --RGAIADEATKNKDLLVPDEGC---KYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQN---- 365
              :....::..|...|...||..   :|.:||:|||:::...|:||..|.....::.:..:
Mouse   403 KTKLESMEKYLKAVKLFRNDENSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQAC 467

  Fly   366 -SEKNGYP-------------------MEIKVS-------LIGSCTNSSYEDMGRCAS-IANDAL 402
             :||.|:.                   .|.|:|       .:.||||:....:...|. :|..|:
Mouse   468 LNEKVGFKGFQVAAEKQSDTVSVRYDGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAV 532

  Fly   403 GHGL--KSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIG------QWDRKDVK 459
            ..||  |..:..:::|||..|...::..|::..|.|.|..::...|..|:|      :.....||
Mouse   533 EIGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVK 597

  Fly   460 MGEKNTI-VTSYNRNFTGRNDANPATHC----FVTSPEMATALAIAGRLDFNPMTDELTGTDG-- 517
            .|:..|. |.|.|::|.||     ...|    ::.||.:..|.||||.::.:..|:.| |||.
Mouse   598 QGDLVTCGVLSGNKHFEGR-----LCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPL-GTDSTG 656

  Fly   518 ----------------------------KTFKLKEPHGE------ELPSKGFDPGE--DTYQAPP 546
                                        ||.|.|...|.      |.|.....|.:  .||...|
Mouse   657 KEIYLHDIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRCP 721

  Fly   547 AKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAG------PWLKY- 604
            :..|  |:..:|.:.     :|.|        :..||:.:....||||||.||      ...||
Mouse   722 SFFD--KLTKEPAAS-----QPIE--------NAHVLLYLGDSVTTDHISPAGSIARSSAAAKYL 771

  Fly   605 ------------------------RGHLDNIS-NNMFIGATNAENNEMNKVKNQKTGSFDAVPAV 644
                                    ||...||. .|.|||....:.  ::....|....|:|
Mouse   772 TNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKT--IHFPSGQTLDVFEA---- 830

  Fly   645 ARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFAN 709
            |..|:...|....:..:.||.|:||:.||..|..||..|::.:|:.:||:.:|...|:..|.|..
Mouse   831 AELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLP 895

  Fly   710 PGDYDKVQPSSK--ISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTLNELQIQWFQAGSALNLM 772
            ..:.|.:..|.:  .|:...::|.||  :...||.:...:...:....|:::|..::.|..||.:
Mouse   896 GENADSLGLSGREVFSLSFPEELFPG--ITLNIKTSTGKEFSVIASFANDVEITLYKHGGLLNFV 958

Fly 773 772
Mouse 959 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	232/953 (24%)
		AcnA_Mitochondrial	93..503	CDD:153134	142/561 (25%)
		Aconitase_swivel	585..733	CDD:294147	46/181 (25%)
Ireb2	NP_073146.2	PTZ00092	3..961	CDD:240263	237/975 (24%)
		AcnA_IRP	85..641	CDD:153136	142/561 (25%)
		AcnA_IRP_Swivel	745..913	CDD:238812	45/173 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820