DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and aco1

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001030155.1	Gene:	aco1 / 568448	ZFINID:	ZDB-GENE-031118-76	Length:	890	Species:	Danio rerio

Alignment Length:	924	Identity:	249/924 - (26%)
Similarity:	379/924 - (41%)	Gaps:	244/924 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAGSMVRNFHTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQP 75
            |..|.|||        ||:..:...|.                           ||:|...:.|
Zfish    42 LLESAVRN--------CDQFLVKQDDV---------------------------EKILNWKVTQ- 70

  Fly    76 DSQEIERGKSYLRLRPDRVALQDATAQMTLLQF--ISSGLKKV---------AVPSTVHCDHLIE 129
             ||.:|     :..||.||.|||.|....::.|  :...:||:         ..|:.:..||.|:
Zfish    71 -SQTVE-----VPFRPARVILQDFTGVPAVVDFAAMRDAVKKLQGDPEKINPVCPADLVIDHSIQ 129

  Fly   130 AQISGDKD-LARAKDL----NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILE----------N 178
            ...:...| |.:.:||    |:|.::||. .:.|..|:....|||||:||:.||          .
Zfish   130 VDFNRKSDSLQKNQDLEFERNRERFEFLKWGSKAFRNMRIIPPGSGIVHQVNLEYLARVVFDQDG 194

  Fly   179 YAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPK 243
            :.:|..| :||||||....|||.|..||||.:|..||...|..:..|.|||..|.|....:.:..
Zfish   195 FYYPDSL-VGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPEVIGYRLLGTPDKYITST 258

  Fly   244 DVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRAT 308
            |::|.|.:.|...|..|..||:.||||..:|....|||.||..|.|||.:.||.::..:.||:.|
Zfish   259 DIVLTVTKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDQISIQYLKQT 323

  Fly   309 GR---------------GAIADEATKNKDLLVPDEGCKYDKVIEINLDTLEPLVNGPFTPDLAHP 358
            ||               |...|.:...:|   |    ::.:|:|::|.|:||..:||..|.....
Zfish   324 GRDMEKLSYIEKYLKAVGMFRDYSNTAQD---P----QFTQVVELDLTTVEPCCSGPKRPHDRVS 381

  Fly   359 ISKLGQNSE-----KNGY--------------PME------------IKVSLIGSCTNSSYED-M 391
            ::::.::.|     |.|:              |.:            :.::.|.||||:|... |
Zfish   382 VAEMKKDFETCLVAKQGFKGFQVSPDRCDVQVPFQFNGAEYSLAHGSVVIAAITSCTNTSNPSVM 446

  Fly   392 GRCASIANDALGHGL--KSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIG--- 451
            .....:|..|:..||  |..:..:::|||..|...:...|::|.|.:.|..|:...|..|||
Zfish   447 LGAGLLAQKAVQAGLTVKPYIKTSLSPGSGVVTYYLKESGVMDFLSQLGFEVVGYGCMTCIGNSG 511

  Fly   452 -----------QWDRKDVKMGEKNTIVTSYNRNFTGRNDANPATHC-FVTSPEMATALAIAG--R 502
                       |.|.  |..|     |.|.||||.||  .:|.|.. ::.||.:..|.||||  |
Zfish   512 PLPEPVVEAITQGDL--VAAG-----VLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTVR 567

  Fly   503 LDF--NPMTDELTGTDGKTFKLKE--PHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRL 563
            :||  .|:.   ..::||...|::  |..||:.:      .:.....||...::...|:..::|.
Zfish   568 IDFEKQPLA---VNSEGKEVYLRDIWPTREEIQA------VERQFVIPAMFKEVYEKVEKVNERW 623

  Fly   564 QLLE-PFEK---WD-GKDYI--------------------DLMVLIKIKGKCTTDHISAAGPWLK 603
            ..|: |.:|   || ...||                    |..||:.:....||||||.||
Zfish   624 NSLKAPSDKLYTWDPNSTYIKSPPFFDGLTRELQTPKPITDAYVLLNLGDSVTTDHISPAG---- 684

  Fly   604 YRGHLDNISNNMFI-------GATNAENNE---------------------MNKVKNQK------ 634
                  ||:.|...       |.|..|.|.                     .||..|::
Zfish   685 ------NIARNSSAARYLTSRGLTAREFNSYGSRRGNDAVMARGTFANIRLFNKFINKQSPTTIY 743

  Fly   635 --TG-SFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETN 696
              || :.|...|..:..:|........|:| ||.||||:.||..|..||..|::.:|:.|||.:|
Zfish   744 LPTGETLDVFDAAEKYQQAGHPLLILAGKE-YGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSN 807

  Fly   697 LKKQGMLALTFANPGDYDK---VQPSSKISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTLNEL 758
            |...|::.|.:. |||..:   :....:.:::....|.|...||.:: :.|.:.:.::... .::
Zfish   808 LVGMGVIPLEYL-PGDSAESLGLSGRERYTVMIPPLLKPRMTVDIKL-DTGKTFQARMRFD-TDV 869

  Fly   759 QIQWFQAGSALNLM 772
            ::.:|..|..||.|
Zfish   870 ELTYFHHGGILNYM 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	240/890 (27%)
		AcnA_Mitochondrial	93..503	CDD:153134	150/502 (30%)
		Aconitase_swivel	585..733	CDD:294147	49/187 (26%)
aco1	NP_001030155.1	PTZ00092	3..886	CDD:240263	249/924 (27%)
		AcnA_IRP	82..566	CDD:153136	150/500 (30%)
		AcnA_IRP_Swivel	670..837	CDD:238812	48/178 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820