DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAcon2 and Aco1

DIOPT Version :9

Sequence 1:NP_650042.2 Gene:mAcon2 / 41326 FlyBaseID:FBgn0037862 Length:783 Species:Drosophila melanogaster
Sequence 2:NP_059017.2 Gene:Aco1 / 50655 RGDID:2019 Length:889 Species:Rattus norvegicus


Alignment Length:869 Identity:238/869 - (27%)
Similarity:357/869 - (41%) Gaps:207/869 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 EKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQF--ISSGLKKV---------AV 118
            |.:|...:.|..|.|:.       .:|.||.|||.|....::.|  :...:||:         ..
  Rat    61 ENILNWSIMQHKSIEVP-------FKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVC 118

  Fly   119 PSTVHCDHLIEAQISGDKD-LARAKDL----NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILE 177
            |:.:..||.|:...:...| |.:.:||    |:|.::||. .:.|..|:....||||||||:.||
  Rat   119 PADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLE 183

  Fly   178 NYA----------FPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHL 232
            ..|          :|..| :||||||....|||.|..||||.:|..||...|..:..|.|||..|
  Rat   184 YLARVVFDQDGCYYPDSL-VGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKL 247

  Fly   233 TGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPF 297
            .||.....:..|::|.:.:.|...|..|..||:.||||..:|....|||.||..|.|||.:.||.
  Rat   248 MGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPV 312

  Fly   298 NERMVTYLRATGR---------------GAIADEATKNKDLLVPDEGCKYDKVIEINLDTLEPLV 347
            :...:.||..|||               |...|.:..::|   ||    :.:|:|::|.|:.|..
  Rat   313 DNVSIAYLVQTGREEDKVKHIKRYLQAVGMFRDFSDSSQD---PD----FTQVVELDLKTVVPCC 370

  Fly   348 NGPFTPDLAHPISKLGQNSE-----KNGYP--------------------------MEIKVSLIG 381
            :||..|.....:|::.::.|     |.|:.                          ..:.::.|.
  Rat   371 SGPKRPQDKVAVSEMKRDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNDSEFTLAHGSVVIAAIT 435

  Fly   382 SCTNSSYEDM----GRCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVL 442
            ||||:|...:    |..|..|.:| |..:|..|..:::|||..|...:...|::..|.:.|..|:
  Rat   436 SCTNTSNPSVMLGAGLLAKKAVEA-GLNVKPYVKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVV 499

  Fly   443 ANACGPCIGQWDR------KDVKMGEKNTI-VTSYNRNFTGRNDANPATHC-FVTSPEMATALAI 499
            ...|..|||....      :.:..|:...: |.|.||||.||  .:|.|.. ::.||.:..|.||
  Rat   500 GYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAI 562

  Fly   500 AG--RLDFN-------------------PMTDELTGTDGKTF---KLKEPHGE-ELPSKGFD--- 536
            ||  |:||.                   |..||:...:.|..   ..||.:.: |..:|.::   
  Rat   563 AGTVRIDFEKEPLGVNAQGQQVFLKDIWPTRDEIQEVERKYVIPGMFKEVYQKIETVNKSWNALA 627

  Fly   537 -PGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAG- 599
             |.|..|...| |:..||.....:|..|.|..|      |..:|..||:.:....||||||.|| 
  Rat   628 APSEKLYAWNP-KSTYIKSPPFFESLTLDLQPP------KSIVDAYVLLNLGDSVTTDHISPAGN 685

  Fly   600 -----PWLKY---RGHLDNISNN---------MFIGATNAENNEMNKVKNQKTGS---------- 637
                 |..:|   ||......|:         :....|.|....:||..|::...          
  Rat   686 IARNSPAARYLTNRGLTPRDFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETL 750

  Fly   638 --FDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQ 700
              |||    |..|:...:....:..:.||.||||:.||..|..||..|::.:|:.|||.:||...
  Rat   751 DVFDA----AERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGM 811

  Fly   701 GMLALTFANPGDY-----------------DKVQPSSKISILNLKDLAPGKPVDAEIKNNGSSDK 748
            |::.|.:. ||:.                 :.::|..|:.|    .|..||...|.::.:     
  Rat   812 GVIPLEYL-PGETADSLGLTGRERYTIHIPEDLKPRMKVQI----KLDTGKTFQAVMRFD----- 866

  Fly   749 IQLNHTLNELQIQWFQAGSALNLM 772
                   .::::.:|..|..||.|
  Rat   867 -------TDVELTYFHNGGILNYM 883

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
mAcon2NP_650042.2 aconitase_mito 43..772 CDD:273561 237/867 (27%)
AcnA_Mitochondrial 93..503 CDD:153134 149/496 (30%)
Aconitase_swivel 585..733 CDD:294147 49/194 (25%)
Aco1NP_059017.2 PTZ00092 3..889 CDD:240263 238/869 (27%)
Substrate binding. /evidence=ECO:0000250 205..207 1/1 (100%)