DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAcon2 and ACO2

DIOPT Version :9

Sequence 1:NP_650042.2 Gene:mAcon2 / 41326 FlyBaseID:FBgn0037862 Length:783 Species:Drosophila melanogaster
Sequence 2:NP_001089.1 Gene:ACO2 / 50 HGNCID:118 Length:780 Species:Homo sapiens


Alignment Length:763 Identity:537/763 - (70%)
Similarity:621/763 - (81%) Gaps:4/763 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VRNFHTARFPRCD--KVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQPDSQ 78
            ||.:|.|.. .|.  |||||:|:....:.|..|.:|::.::.||..|||||||::|.|||.|.||
Human    17 VRQYHVASV-LCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQ 80

  Fly    79 EIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIEAQISGDKDLARAKD 143
            |||||||||||||||||:|||||||.:||||||||.|||||||:|||||||||:.|:|||.||||
Human    81 EIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKD 145

  Fly   144 LNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGCLCVGVGG 208
            :|:|||:||::|.|||.:|||||||||||||||||||:||:|:||||||||||||||.:|:||||
Human   146 INQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGG 210

  Fly   209 ADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESI 273
            ||||||||.||||||||.|||..|||.:|||:||||||||||.|||||||||||||||||||:||
Human   211 ADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSI 275

  Fly   274 SCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATKNKDLLVPDEGCKYDKVIEI 338
            ||||||||.|||||||||||:||:|.||..||..|||..||:.|.:.||.||||.||.||::|||
Human   276 SCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEI 340

  Fly   339 NLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYEDMGRCASIANDALG 403
            ||..|:|.:|||||||||||::::|:.:||.|:|::|:|.|||||||||||||||.|::|..||.
Human   341 NLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALA 405

  Fly   404 HGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMGEKNTIVT 468
            ||||....|.:||||||:||||.|||...:|...||.|||||||||||||||||:|.||||||||
Human   406 HGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVT 470

  Fly   469 SYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKTFKLKEPHGEELPSK 533
            ||||||||||||||.||.||||||:.|||||||.|.|||.||.|||||||.|:|:.|..:|||..
Human   471 SYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKG 535

  Fly   534 GFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAA 598
            .||||:||||.||..:....|:|.|.|.||||||||:||||||..||.:|||:||||||||||||
Human   536 EFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAA 600

  Fly   599 GPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYKANKIKWCAVGEENY 663
            |||||:||||||||||:.|||.|.||.:.|.|:|..|..|..||..||.||.:.|:|..:|:|||
Human   601 GPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENY 665

  Fly   664 GEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSKISILNLK 728
            ||||||||||||||||||.|||.|||||||||||||||:|.||||:|.||:|:.|..|::|..||
Human   666 GEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLK 730

  Fly   729 DLAPGKPVDAEIKN-NGSSDKIQLNHTLNELQIQWFQAGSALNLMKEL 775
            |..||||:...||: ||:.:.|.||||.||.||:||:||||||.||||
Human   731 DFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL 778

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
mAcon2NP_650042.2 aconitase_mito 43..772 CDD:273561 522/729 (72%)
AcnA_Mitochondrial 93..503 CDD:153134 311/409 (76%)
Aconitase_swivel 585..733 CDD:294147 102/147 (69%)
ACO2NP_001089.1 AcnA 45..775 CDD:333196 522/729 (72%)
Substrate binding. /evidence=ECO:0000250 192..194 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 528..560 15/31 (48%)