DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and aco2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001011445.1	Gene:	aco2 / 496933	XenbaseID:	XB-GENE-1000785	Length:	781	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	538/777 - (69%)
Similarity:	629/777 - (80%)	Gaps:	12/777 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CLAGSMV--------RNFHTARFPRCD--KVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLS 64
            ||..|.:        |.:|.:.. .|.  |||||:|:....:.|::|.:|::.::.||..|||||
Frog     5 CLLASRLQQALGHGARRYHVSSV-LCQRAKVAMSHFEANEYINYERLDKNINIVRKRLDRPLTLS 68

  Fly    65 EKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIE 129
            ||::|.|:|.|.:||:.|||:||||||||||:|||||||.:||||||||.:||||||:|||||||
Frog    69 EKIVYGHIDDPVTQEVVRGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPRVAVPSTIHCDHLIE 133

  Fly   130 AQISGDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTP 194
            ||:.|:|||.||||:|:|||:||::|.|||.:||||||||||||||||||||||:|:||||||||
Frog   134 AQLGGEKDLKRAKDINQEVYNFLATAAAKYGVGFWKPGSGIIHQIILENYAFPGVLLIGTDSHTP 198

  Fly   195 NGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGT 259
            ||||||.:|:||||||||||||.||||||||.|||..|||::||||||||||||||.||||||||
Frog   199 NGGGLGGICIGVGGADAVDVMAGIPWELKCPNVIGVKLTGQLSGWTSPKDVILKVAGILTVKGGT 263

  Fly   260 GAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATKNKDLL 324
            |||||||||||:||||||||||.|||||||||||:||:|.||..||..|||.|||..|.:.|..|
Frog   264 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLDKTGRSAIASLADEFKSHL 328

  Fly   325 VPDEGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYE 389
            ||||||:||::||||||.|:|.:|||||||||:|:|::|..:|:.|:|::|:|.|||||||||||
Frog   329 VPDEGCEYDQLIEINLDELKPHINGPFTPDLANPVSEVGAVAEQKGWPLDIRVGLIGSCTNSSYE 393

  Fly   390 DMGRCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWD 454
            ||||.|::|..||.||||....|.:||||||:||||.|||...||...||.||||||||||||||
Frog   394 DMGRAAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAAVLRDVGGVVLANACGPCIGQWD 458

  Fly   455 RKDVKMGEKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKT 519
            |||:|.||||||||||||||||||||||.||.||||||:.|||:|||.|.|:|..|.|||.|||.
Frog   459 RKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALSIAGTLKFDPEKDFLTGADGKK 523

  Fly   520 FKLKEPHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLI 584
            |||:.|..:|||...||||:||||.||.:...:||:|.|.|.||||||||:||||||..::.:|:
Frog   524 FKLQPPDADELPKSSFDPGQDTYQHPPKEGSSLKVDVSPTSQRLQLLEPFDKWDGKDLENMQILV 588

  Fly   585 KIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYK 649
            |:|||||||||||||||||:||||||||||:.|||.|.|||:.|.|||.....:.|||..||.||
Frog   589 KVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINLENNKANSVKNCVNQEYGAVPDTARYYK 653

  Fly   650 ANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYD 714
            |:.|||..:|:|||||||||||||||||||||.|||.|||||||||||||||:|.|||::|.|||
Frog   654 AHGIKWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFSDPADYD 718

  Fly   715 KVQPSSKISILNLKDLAPGKPVDAEIKN-NGSSDKIQLNHTLNELQIQWFQAGSALNLMKEL 775
            |:.|..||:|..||.|||||||...|.: |||.:.|.||||.||.||:|||||||||.||||
Frog   719 KIHPEDKITIAELKHLAPGKPVKCIITHQNGSQETILLNHTFNETQIEWFQAGSALNRMKEL 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	522/729 (72%)
		AcnA_Mitochondrial	93..503	CDD:153134	313/409 (77%)
		Aconitase_swivel	585..733	CDD:294147	107/147 (73%)
aco2	NP_001011445.1	aconitase_mito	47..777	CDD:273561	522/729 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	723	1.000	Domainoid score	I114
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I204
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101024at33208
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	1	1.000	-	-		otm47716
Panther	1	1.100	-	-	O	PTHR43160
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3169
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160