DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and leu2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_594576.1	Gene:	leu2 / 2543296	PomBaseID:	SPAC9E9.03	Length:	758	Species:	Schizosaccharomyces pombe

Alignment Length:	828	Identity:	209/828 - (25%)
Similarity:	314/828 - (37%)	Gaps:	216/828 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LGGPLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVP-- 119
            :..|.||.:||..||:  .|.||......|:    ||..:.:.|:........::| :||..|
pombe     5 VASPKTLYDKVWDSHV--VDLQEDGTCLLYI----DRHLIHEVTSPQAFEGLRTAG-RKVRHPEL 62

  Fly   120 --STVHCDHLIEAQISGD-KDLA---RAKDLNKEVYDFLSSACAKYNLGFWKPG---SGIIHQII 175
              :||  ||.|......| ||:|   ...|...:|. .|.:...::.|.::...   .||:|.|.
pombe    63 ALATV--DHNIPTDPRKDMKDIASFIHQPDSRTQVL-ALENNIKEFGLTYYGMNDRRQGIVHVIG 124

  Fly   176 LE-NYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGW 239
            .| .:..||..::..||||...|..|.|..|:|.::...|:|......:....:...:.||:...
pombe   125 PEQGFTLPGTTLVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQRKSKNMRIRVNGKLPEG 189

  Fly   240 TSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTY 304
            .:.||:||.:..::...||||:::|:.|..:|.:|.....::.||..|.||
pombe   190 IASKDLILHIIGVIGTAGGTGSVIEFCGEAIEGLSMEARMSMCNMSIEAGA-------------- 240

  Fly   305 LRATGRGAIADEAT-----KNKDL----------------LVPDEGCKYDKVIEINLDTLEPLV- 347
             ||   |.||.:||     ||:.|                |..||..|||..:|||...:.|.|
pombe   241 -RA---GMIAPDATTFEYVKNRPLAPKGDDWEQAVAYWKTLRSDENAKYDIEVEINAADVLPTVT 301

  Fly   348 -----------NGPFTPDLAH--------PISK------LGQNSEKNGYPMEIKVSLIGSCTNSS 387
                       ||.. ||.||        .|.:      |..|:....||:: || .|||||||.
pombe   302 WGTSPQDVIPINGNI-PDPAHVKDNVRAASIQRSLEYMGLKPNTSIVSYPID-KV-FIGSCTNSR 363

  Fly   388 YEDMGRCASI-------AN--DALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLA 443
            .||:...|::       ||  ||:           :.|||..|:.....:|:..:..:.|.....
pombe   364 IEDLRLAAAVVKGRKVAANVKDAM-----------IVPGSGLVKKMAEAEGLDQIFIEAGFDWRE 417

  Fly   444 NACGPCIGQWDRKDVKMGEKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPM 508
            ..|..|:|. :...:|..|:  ..::.||||.||..|...||  :.||.||.|.||.|.|
pombe   418 AGCSMCLGM-NPDQLKPYER--CASTSNRNFEGRQGAKGRTH--LVSPAMAAAAAIKGHL----- 472

  Fly   509 TDELTGTDGKTFKLKEPHGEE-------LPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLL 566
                       ..::|..|:.       :.:|.:||..|.       ..||.::||..:|.:
pombe   473 -----------CNVREFFGDVSNGSPSIITNKNYDPSHDV-------EGDIGLSVDDATDAV--- 516

  Fly   567 EPFEKWDGKDYIDLMVLIKIKGKCTT-----------DHISAAGPWLKYRGHLDNISNNMFIGAT 620
               ...||       :...:.|..::           :.|:|..|       :.|:..:..|
pombe   517 ---TDADG-------IATNVAGSVSSGSAGIPKFTVVEGIAAPLP-------MANVDTDKII--- 561

  Fly   621 NAENNEMNKVKNQKTGSF-------DAVPAVARDYKANKIKW----CAVGEENYGEGSSREHAAL 674
              ....:..:|....|.|       ||......|:..|:..:    ..|..:|:|.|||||||..
pombe   562 --PKQFLKTIKRTGLGQFAFYEIRYDADGKEIPDFVLNREPYRHATVLVAHDNFGCGSSREHAPW 624

  Fly   675 EPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSK---------ISILNLKDL 730
            .....|...||..|||.|...|..|.|||.:    |...::|....|         :.::|....
pombe   625 ALNDFGIRVIIAPSFADIFFNNCFKNGMLPI----PTPIEQVNDMMKAAENQVKFSVDLVNQTIT 685

  Fly   731 APGKPVDAEIKN-------NGSSDKIQLNHTL-NELQIQWFQAGSALN 770
            ...|.|..:::.       ||..|   :..|| .|..|..|:|....|
pombe   686 YGDKQVKFDVEPFRKHCLVNGLDD---IGLTLQKETMIDAFEAAREEN 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	209/828 (25%)
		AcnA_Mitochondrial	93..503	CDD:153134	132/477 (28%)
		Aconitase_swivel	585..733	CDD:294147	39/178 (22%)
leu2	NP_594576.1	PRK05478	7..478	CDD:235490	145/533 (27%)
		aconitase_mito	8..681	CDD:273561	196/771 (25%)
		leuD	539..734	CDD:179314	50/211 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870