DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and lys2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_593437.1	Gene:	lys2 / 2542867	PomBaseID:	SPAC343.16	Length:	721	Species:	Schizosaccharomyces pombe

Alignment Length:	754	Identity:	182/754 - (24%)
Similarity:	302/754 - (40%)	Gaps:	138/754 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHC 124
            |.|::||::..........:..|...|:.::|......| .:....|:|:..|.|||.....:.|
pombe    60 PQTITEKIVQKFAQNIPENKYVRSGDYVTIKPKHCMSHD-NSWPVALKFMGIGAKKVFDNRQIVC 123

  Fly   125 --DHLIEAQISGDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILE-NYAFPGLLM 186
              ||          |:....:.|...|..:.|......:.|:..|.||.|||::| .||.||.:.
pombe   124 TLDH----------DVQNKSEANLRKYKNIESFAKGQGIDFYPAGRGIGHQIMVEQGYAMPGSMA 178

  Fly   187 IGTDSHTPNGGGLGCLCVGVGGADAVDVMA--NIPWELKCPTVIGCHLTGKISGWTSPKDVILKV 249
            :.:|||:...||:|||...:...||..:.|  ...|::  |.:...:|.|::....|.||:|:.:
pombe   179 VASDSHSNTYGGVGCLGTPIVRTDAAAIWATGQTWWQI--PPIARVNLVGQLPKGLSGKDIIVSL 241

  Fly   250 AEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTY----LRATG- 309
            .............:|::|.|:.|:|.....||.||..|.||.:.:||.:|:::.:    |:..|
pombe   242 CGAFNHDEVLNHAIEFYGEGLNSLSIESRLTIANMTTEWGALSGLFPTDEKLLAWYEDRLKFLGP 306

  Fly   310 ------RGAIADEATKNKDLLVPDEGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEK 368
                  |..:  :|.|...:|. |||..|.|.:.::|.||.|.|:||.:..:.:..:.|    ||
pombe   307 NHPRVNRETL--DAIKASPILA-DEGAFYAKHLILDLSTLSPAVSGPNSVKVYNSAATL----EK 364

  Fly   369 NGYPMEIKVSLIGSCTNSSYEDMGRCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDV 433
            .  .:.||.:.:.||||....|:...|....   |..:...|.|.|...|.:|.|...::|....
pombe   365 K--DILIKKAYLVSCTNGRLSDIHDAAETVK---GKKVADGVEFYVGAASSEVEAAAQKNGDWQT 424

  Fly   434 LEKFGGTVLANACGPCIGQWD--RKDVKMGEKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATA 496
            |...|...|...||||||...  .||.::|     :::.||||.||..:..|. .::.||.:..|
pombe   425 LIDSGARTLPAGCGPCIGLGTGLLKDGEVG-----ISATNRNFKGRMGSREAL-AYLASPAVVAA 483

  Fly   497 LAIAGRL----DFNPMTDELTGTDGKTFKLKEPHGEELPSKGFDPGEDTYQA-----PPAKADDI 552
            .||||::    .|......::..|     :.:...::..||......|:..|     |...|.:|
pombe   484 SAIAGKIVAPEGFKNAVSLVSAVD-----ITDKVNKQTASKSSTEAVDSETAIIDGFPSIVAGEI 543

  Fly   553 KVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFI 617
            ..                                   |..|:::..|.:.....:.|:|:
pombe   544 VF-----------------------------------CDADNLNTDGIYPGRYTYRDDIT----- 568

  Fly   618 GATNAENNEMNKVKNQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGV 682
                  ..||.||..:   ::|:  ...:..|.:.|   .|...|:|.|||||.||......|..
pombe   569 ------KEEMAKVCME---NYDS--EFGKKTKKDDI---LVSGFNFGTGSSREQAATAILSRGIP 619

  Fly   683 AIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSKISILNLKDLA--PGKPVDAEIKNN-- 743
            .::..||:.|.:.|.....:||:...     |.||..........|:|.  .|..:..:::.:
pombe   620 LVVGGSFSDIFKRNSINNALLAIQLP-----DLVQKLRTAFANESKELTRRTGWHLKWDVRKSTV 679

  Fly   744 --GSSDKIQLNHTLNELQIQWFQAGSALNLMKELAAKGG 780
              .:||..:::..:.||.          |.::.|..:||
pombe   680 TVTTSDNKEMSWKIGELG----------NSVQSLFVRGG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	179/744 (24%)
		AcnA_Mitochondrial	93..503	CDD:153134	123/427 (29%)
		Aconitase_swivel	585..733	CDD:294147	34/149 (23%)
lys2	NP_593437.1	h_aconitase	60..717	CDD:129245	182/754 (24%)
		Homoaconitase	93..490	CDD:153132	123/427 (29%)
		Homoaconitase_Swivel	546..674	CDD:238837	35/151 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770