Protein Alignment mAcon2 and aco1

DIOPT Version :10

• Sequence 1: NP_650042.2
• Gene: mAcon2 / 41326
• FlyBaseID: FBgn0037862
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: NP_594031.2
• Gene: aco1 / 2541450
• PomBaseID: SPAC24C9.06C
• Length: 789
• Species: Schizosaccharomyces pombe
• Alignment Length: 768
• Identity: 502/768 - (65%)
• Similarity: 594/768 - (77%)
• Gaps: 8/768 - (1%)

  Fly    14 SMVRNFHTARFPR---CDKVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQP 75
            |.:|:|..|....   ..|||||||:....:.|:::::||:.:|.||..|||.|||:||.|||.|
pombe    20 STLRSFSCAPVAANIDAKKVAMSNFEKNKFINYQRIKDNLEIVKKRLNRPLTYSEKILYGHLDDP 84

  Fly    76 DSQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIEAQISGDKDLAR 140
            .:|:||||.|||:|||||||.|||||||.:|||:|:|:.:||||.||||||||||...|..||.|
pombe    85 VNQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGMPEVAVPVTVHCDHLIEAYEGGPIDLER 149

  Fly   141 AKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGCLCVG 205
            |...||||||||.:||||||:|||:|||||||||:||||||||.|:|||||||||.||||.:.:|
pombe   150 ANVTNKEVYDFLQTACAKYNIGFWRPGSGIIHQIVLENYAFPGGLLIGTDSHTPNAGGLGMVAIG 214

  Fly   206 VGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGV 270
            ||||||||||||:|||||||.|||..|||::.|||||||||||||.||||||||||||||.||||
pombe   215 VGGADAVDVMANLPWELKCPKVIGVKLTGQLKGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGV 279

  Fly   271 ESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATKNKDLLVPDEGCKYDKV 335
            ||:|||||.||.||||||||||||||||.||..|||||.|.||||.|.:...::..||...||::
pombe   280 ESLSCTGMGTICNMGAEIGATTSIFPFNPRMSEYLRATNRSAIADYAEEFAPIIAADENAHYDQI 344

  Fly   336 IEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYEDMGRCASIAND 400
            |||:|:||||.:|||||||||.||||..:..:||.:|.|:||.|||||||||||||.|.|||...
pombe   345 IEIDLNTLEPHLNGPFTPDLATPISKFKEAVKKNDWPQELKVGLIGSCTNSSYEDMSRAASICQQ 409

  Fly   401 ALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMGEKNT 465
            |:..|:|:...|.:||||||||||:.|||.:|.:.|.||.|||||||||||||.|.|||.||||:
pombe   410 AIDKGIKTKSLFTITPGSEQVRATLTRDGQLDTMRKAGGIVLANACGPCIGQWKRTDVKKGEKNS 474

  Fly   466 IVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKTFKLKEPHGEEL 530
            ||||||||||||||||||||.|||||::.||:..:|.::|||:||.|...||..||.:.|.|..|
pombe   475 IVTSYNRNFTGRNDANPATHAFVTSPDIVTAMVFSGDMNFNPLTDTLKDKDGNDFKFEPPTGAGL 539

  Fly   531 PSKGFDPGEDTYQAPPAKADDIK-VNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDH 594
            ||||:|||.:||.||  .:.::| |.:||.|.|||.|.||:||||||...|.:|||.||||||||
pombe   540 PSKGYDPGSNTYVAP--SSVNVKDVAIDPHSKRLQRLTPFKKWDGKDMKGLKILIKAKGKCTTDH 602

  Fly   595 ISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYKANKIKWCAVG 659
            ||||||||||||||.|||||..|||.||||.|.||:|:|.||.:..||.||.||:.:.|:|..:|
pombe   603 ISAAGPWLKYRGHLQNISNNYMIGAINAENGEANKLKDQLTGEYKTVPNVAIDYRDHGIRWVTLG 667

  Fly   660 EENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSKISI 724
            |:|:||||||||||||||:|||.|:|.|||||||||||||||:|.||||:|..|||:.|...:.|
pombe   668 EQNFGEGSSREHAALEPRYLGGAAVITKSFARIHETNLKKQGLLPLTFADPAAYDKISPFDTVDI 732

  Fly   725 LNLKDLAPGKPVDAEI-KNNGSSD-KIQLNHTLNELQIQWFQAGSALNLMKEL 775
            ..|...|||||:...: ..:||:: ..:||||.|:.||:||:||||||.|..:
pombe   733 DGLTTFAPGKPLTLVVHPADGSAEWSTKLNHTFNKDQIEWFKAGSALNHMANM 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	490/731 (67%)
aco1	NP_594031.2	aconitase_mito	52..782	CDD:273561	490/731 (67%)