DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and SPBP4H10.15

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_596189.3	Gene:	SPBP4H10.15 / 2541348	PomBaseID:	SPBP4H10.15	Length:	918	Species:	Schizosaccharomyces pombe

Alignment Length:	802	Identity:	417/802 - (51%)
Similarity:	535/802 - (66%)	Gaps:	30/802 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQRTHRYICLAGSMVR------NFHTARFPRCDKVAMSNFDTGIPLPYKKLRENLDCIKGRL-G 58
            ||......:||:||...      :...|||.  ...:.:::.|.   ||:||...|..::..| |
pombe     1 MATFARMKLCLSGSSQAIPSKGISLVAARFQ--STASRASYVTP---PYEKLMGKLQQVRKFLPG 60

  Fly    59 GPLTLSEKVLYSHLDQPD------SQEIERGKSYLRLRPDRVALQDATAQMTLLQFISSGLKKVA 117
            ..|||:||||||||..|:      |....||..||:|.|||||:|||:|||.||||::.||:|..
pombe    61 QKLTLAEKVLYSHLVNPEESFSGVSPSDIRGSLYLKLNPDRVAMQDASAQMALLQFMTCGLEKTM 125

  Fly   118 VPSTVHCDHLIEAQISGDKDLARAKDLNKEVYDFLSSACAKYNLGFWKPGSGIIHQIILENYAFP 182
            :|:::||||||......:.|:..:...|||::|||.||..||.:.||.|||||||||:|||||.|
pombe   126 IPASIHCDHLIVGHRGANSDIPDSIANNKEIFDFLQSAAKKYGIQFWGPGSGIIHQIVLENYAAP 190

  Fly   183 GLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVIL 247
            |.:|:||||||||.||||.:.:|||||||||.|.|.|||||.|.:||.:|||.:||||:|||:||
pombe   191 GGMMLGTDSHTPNAGGLGMIAIGVGGADAVDAMTNTPWELKAPKIIGVNLTGAMSGWTTPKDLIL 255

  Fly   248 KVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRGA 312
            .:|..|||:||||.|:||.||||.|:|||||||:.|||||:||||||||:.:.|..||.||.|..
pombe   256 HLAGKLTVRGGTGHIIEYFGPGVASLSCTGMATVCNMGAEVGATTSIFPYTDSMRRYLIATHRAE 320

  Fly   313 IADEATK---NKDLLVPDEGCKYDKVIEINLDTLEPLVNGPFTPDLAHPISKLGQNSEKNGYPME 374
            :||.|::   ..:.|..|.|.|||::|:|||..|.|.:||||||||:.|:||.|:..|||.:|.:
pombe   321 VADAASEVHSEYNYLAADTGAKYDQIIDINLSELTPSLNGPFTPDLSTPVSKFGEAIEKNKWPKK 385

  Fly   375 IKVSLIGSCTNSSYEDMGRCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGG 439
            :...||||||||||:||.....:...|:..|||..|||.|||||||:||||.||||.:.||:.|.
pombe   386 LSAGLIGSCTNSSYQDMTCVVDVVEQAISAGLKPKVPFLVTPGSEQIRATIERDGITERLEEAGA 450

  Fly   440 TVLANACGPCIGQWDR-KDVKMGEKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRL 503
            ||||||||||||.|.| .|:..||.|.|:||:||||..|||.||:|..|:|||.:..|...:..|
pombe   451 TVLANACGPCIGMWKRTDDIASGEPNAILTSFNRNFRSRNDGNPSTMNFLTSPVIVAAKIFSSDL 515

  Fly   504 DFNPMTDELTGTDGKTFKLKEPHGEELPSKGFDPGEDTY--QAPPAKADDIKVNVDPKSDRLQLL 566
            .|:|..|.|...|||.||.:.|.|.||||.||..|:.:|  :..|....:.:|.:|||||||:.|
pombe   516 AFDPTHDTLQTPDGKAFKFRPPQGVELPSAGFIAGDSSYIPEPNPQPVPETEVTIDPKSDRLEAL 580

  Fly   567 EPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVK 631
            ||||.:.|.:..:|.|.:|:|||||||||||||.||||:|||.||.||..|||.||...|:|:..
pombe   581 EPFEPYQGGEMENLKVAVKVKGKCTTDHISAAGKWLKYKGHLSNICNNTLIGAMNAATGEVNRAY 645

  Fly   632 NQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETN 696
            :...|.  .:|.:...:|.:...|..|.|.||||||:||||||:||.:.|..|:.||||||||||
pombe   646 DNGKGM--TIPELMWKWKKDGQPWLVVAEHNYGEGSAREHAALQPRAMNGRIILTKSFARIHETN 708

  Fly   697 LKKQGMLALTFANPGDYDKVQPSSKISILNLKDLAPG---KPVDAEI-KNNGSSDKIQLNHTLNE 757
            |||||:|.|||.|..||:|:....|:|...::.|..|   :|:...: |.:||..:|...||:::
pombe   709 LKKQGVLPLTFVNEADYEKIDAEDKVSTRGIEQLLEGVLDQPITLVVTKKDGSVVEIPCKHTMSK 773

  Fly   758 LQIQWFQAGSALNLMKELAAKG 779
            .||::|:|||||||::|.|..|
pombe   774 DQIEFFKAGSALNLIREKAHSG 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	402/745 (54%)
		AcnA_Mitochondrial	93..503	CDD:153134	242/413 (59%)
		Aconitase_swivel	585..733	CDD:294147	80/147 (54%)
SPBP4H10.15	NP_596189.3	aconitase_mito	44..788	CDD:273561	402/745 (54%)
		Aconitase	101..515	CDD:294203	242/413 (59%)
		Aconitase_swivel	599..745	CDD:294147	80/147 (54%)
		Ribosomal_L21p	820..908	CDD:279202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	O	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.770