DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and aco-1

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_509898.1	Gene:	aco-1 / 181324	WormBaseID:	WBGene00000040	Length:	887	Species:	Caenorhabditis elegans

Alignment Length:	850	Identity:	231/850 - (27%)
Similarity:	361/850 - (42%)	Gaps:	179/850 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LDQPDSQEIERGKSYLRLRPDRVALQDAT---------AQMTLLQFISSGLKKV--AVPSTVHCD 125
            ||..:||   |.::.:..:|.||.|||.|         |....:|.:.:...|:  ..|..:..|
Worm    62 LDWKNSQ---RNQAEIPFKPARVILQDFTGVPAVVDLAAMRDAVQNMGADPAKINPVCPVDLVID 123

  Fly   126 HLIEAQISGDKD-LARAKDL----NKEVYDFLSSACAKY-NLGFWKPGSGIIHQIILENYA---- 180
            |.::....|:.: ||:.:.:    |:|.::||......: ||....|||||:||:.||..|
Worm   124 HSVQVDHYGNLEALAKNQSIEFERNRERFNFLKWGSKAFDNLLIVPPGSGIVHQVNLEYLARTVF 188

  Fly   181 --FPGLL----MIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISGW 239
              ..|:|    ::||||||....|.|.|..||||.:|..||...|..:..|.|||..|.|.:|..
Worm   189 VGKDGVLYPDSVVGTDSHTTMIDGSGVLGWGVGGIEAEAVMLGQPISMVIPEVIGYELVGTLSDT 253

  Fly   240 TSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVTY 304
            .:..|::|.:.:.|...|..|..||:.|.||.|:|....|||.||..|.|||...||.:.|.:.|
Worm   254 VTSTDLVLTITKNLRDLGVVGKFVEFFGTGVASLSIADRATIANMCPEYGATIGFFPVDSRTIDY 318

  Fly   305 LRATGRGA----IADEATKNKDLLV--PDEGCK--YDKVIEINLDTLEPLVNGPFTPDLAHPISK 361
            |..|||..    ..::..|:..:.|  .|:..:  |...::::|.::.|.|:||..|.....::.
Worm   319 LTQTGRDTDYTQRVEQYLKSVGMFVNFTDDSYRPTYTTTLKLDLGSVVPSVSGPKRPHDRVELAS 383

  Fly   362 LGQNSEK--------------------------NGYPME-----IKVSLIGSCTNSSYEDMGRCA 395
            |.|:..|                          :|...|     :.::.|.||||:|...:...|
Worm   384 LAQDFSKGLTDKISFKAFGLKPEDATKSVTITNHGRTAELTHGSVVIAAITSCTNTSNPSVMLAA 448

  Fly   396 S-IANDA--LGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQ---WD 454
            . :|..|  ||..::..|..:::|||..|...:...|::..|||.|..:....|..|||.   .|
Worm   449 GLVAKKAVELGLNVQPYVKTSLSPGSGVVTKYLEASGLLPYLEKIGFNIAGYGCMTCIGNSGPLD 513

  Fly   455 RKDVKMGEKNTIVT----SYNRNFTGRNDANPATHC-FVTSPEMATALAIAGRLDFNPMTDELTG 514
            ....|..|:|.:|.    |.||||.||  .:|.... ::.||.:|...:|.|.::.     ::.|
Worm   514 EPVTKAIEENNLVVAGVLSGNRNFEGR--IHPHVRANYLASPPLAVLYSIIGNVNV-----DING 571

  Fly   515 T-----DGKTFKLKE--PHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLE----- 567
            .     |||..:|.:  |..:|:..     .|:.: ..|....::..|::..|...|.||
Worm   572 VLAVTPDGKEIRLADIWPTRKEVAK-----FEEEF-VKPQFFREVYANIELGSTEWQQLECPAVK 630

  Fly   568 --------------PFEKWDG--------KDYIDLMVLIKIKGKCTTDHISAAG------PWLKY 604
                          ||  :||        .|.::..||:.:....||||||.||      |..::
Worm   631 LYPWDDASTYIKKVPF--FDGMTSELPSQSDIVNAHVLLNLGDSVTTDHISPAGSISKTSPAARF 693

  Fly   605 -----------------RGHLDNISNNMFIGATNAENNEMNKVKNQKTGS-------------FD 639
                             ||:.:.::...|     |....:||:.: |.|.             ||
Worm   694 LAGRGVTPRDFNTYGARRGNDEIMARGTF-----ANIRLVNKLAS-KVGPITLHVPSGEELDIFD 752

  Fly   640 AVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLA 704
            |    |:.||...|....:..:.||.||||:.||..|...|..|:|.:||.|||.:||...|::.
Worm   753 A----AQKYKDAGIPAIILAGKEYGCGSSRDWAAKGPFLQGVKAVIAESFERIHRSNLIGMGIIP 813

  Fly   705 LTFANPGDYDKVQPSSK--ISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTLNELQIQWFQAGS 767
            ..:....:.|.:..:.|  .||....||.||:.:|..: :|||..::..... .|:::.:::.|.
Worm   814 FQYQAGQNADSLGLTGKEQFSIGVPDDLKPGQLIDVNV-SNGSVFQVICRFD-TEVELTYYRNGG 876

  Fly   768 ALNLM 772
            .|..|
Worm   877 ILQYM 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	230/848 (27%)
		AcnA_Mitochondrial	93..503	CDD:153134	144/486 (30%)
		Aconitase_swivel	585..733	CDD:294147	50/185 (27%)
aco-1	NP_509898.1	PTZ00092	3..887	CDD:240263	230/849 (27%)
		AcnA_IRP	80..565	CDD:153136	144/486 (30%)
		AcnA_IRP_Swivel	668..835	CDD:238812	46/176 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820