DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mAcon2 and aco-2

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_741235.1	Gene:	aco-2 / 176121	WormBaseID:	WBGene00000041	Length:	777	Species:	Caenorhabditis elegans

Alignment Length:	751	Identity:	551/751 - (73%)
Similarity:	628/751 - (83%)	Gaps:	4/751 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KVAMSNFDTGIPLPYKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDR 93
            |||:|.|:....|||:||.:.:..:|.||..|||||||:||.|||||.:|:||||.|||||||||
Worm    28 KVAISKFEPKSYLPYEKLSQTVKIVKDRLKRPLTLSEKILYGHLDQPKTQDIERGVSYLRLRPDR 92

  Fly    94 VALQDATAQMTLLQFISSGLKKVAVPSTVHCDHLIEAQISGDKDLARAKDLNKEVYDFLSSACAK 158
            ||:|||||||.:||||||||.|.|||||:|||||||||..|.:||||||||||||::||::|.:|
Worm    93 VAMQDATAQMAMLQFISSGLPKTAVPSTIHCDHLIEAQKGGAQDLARAKDLNKEVFNFLATAGSK 157

  Fly   159 YNLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELK 223
            |.:||||||||||||||||||||||||:||||||||||||||.||:||||||||||||:||||||
Worm   158 YGVGFWKPGSGIIHQIILENYAFPGLLLIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELK 222

  Fly   224 CPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEI 288
            ||.|||..||||::||||.||||||||:||||||||||||||.||||:|||.|||.||.||||||
Worm   223 CPKVIGIKLTGKLNGWTSAKDVILKVADILTVKGGTGAIVEYFGPGVDSISATGMGTICNMGAEI 287

  Fly   289 GATTSIFPFNERMVTYLRATGRGAIADEATKNKDLLVPDEGCKYDKVIEINLDTLEPLVNGPFTP 353
            |||||:||:||.|..||.||||..||:||.|.||||..|:|..||::||||||||.|.|||||||
Worm   288 GATTSVFPYNESMYKYLEATGRKEIAEEARKYKDLLTADDGANYDQIIEINLDTLTPHVNGPFTP 352

  Fly   354 DLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYEDMGRCASIANDALGHGLKSCVPFNVTPGS 418
            |||..|.|||:|::|||:|:::||||||||||||||||.|.||||..||..|||:...|.:||||
Worm   353 DLASSIDKLGENAKKNGWPLDVKVSLIGSCTNSSYEDMTRAASIAKQALDKGLKAKTIFTITPGS 417

  Fly   419 EQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMGEKNTIVTSYNRNFTGRNDANPA 483
            |||||||.|||:..:...|||.|||||||||||||||:|||.|||||||||||||||||||||||
Worm   418 EQVRATIERDGLSKIFADFGGMVLANACGPCIGQWDRQDVKKGEKNTIVTSYNRNFTGRNDANPA 482

  Fly   484 THCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKTFKLKEPHGEELPSKGFDPGEDTYQAPPAK 548
            ||.|||||::.||:||:|||||||:|||||..||..|||:.|.|.:||.||:||||||:|||...
Worm   483 THGFVTSPDITTAMAISGRLDFNPLTDELTAADGSKFKLQAPTGLDLPPKGYDPGEDTFQAPSGS 547

  Fly   549 ADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAGPWLKYRGHLDNISN 613
            .   :|:|.|.|||||||.||:||||||..|:.:|||:.||||||||||||||||||||||||||
Worm   548 G---QVDVSPSSDRLQLLSPFDKWDGKDLEDMKILIKVTGKCTTDHISAAGPWLKYRGHLDNISN 609

  Fly   614 NMFIGATNAENNEMNKVKNQKTGSFDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRH 678
            |:|:.|.||:|.||||||||.||.:.||||.||.|||:.::|.|:|:||||||||||||||||||
Worm   610 NLFLTAINADNGEMNKVKNQVTGEYGAVPATARKYKADGVRWVAIGDENYGEGSSREHAALEPRH 674

  Fly   679 LGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSKISILNLKDLAPGKPVDAEI-KN 742
            |||.|||||||||||||||||||||.||||||.||||:.||..:||:.|...|||||:.|.. |.
Worm   675 LGGRAIIVKSFARIHETNLKKQGMLPLTFANPADYDKIDPSDNVSIVGLSSFAPGKPLTAIFKKT 739

  Fly   743 NGSSDKIQLNHTLNELQIQWFQAGSALNLMKELAAK 778
            |||..::.||||.||.||:||:||||||.|||:.||
Worm   740 NGSKVEVTLNHTFNEQQIEWFKAGSALNRMKEVFAK 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	539/729 (74%)
		AcnA_Mitochondrial	93..503	CDD:153134	316/409 (77%)
		Aconitase_swivel	585..733	CDD:294147	113/147 (77%)
aco-2	NP_741235.1	aconitase_mito	42..769	CDD:273561	539/729 (74%)
		AcnA_Mitochondrial	92..502	CDD:153134	316/409 (77%)
		AcnA_Mitochon_Swivel	581..729	CDD:238810	113/147 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158758
Domainoid	1	1.000	718	1.000	Domainoid score	I43
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1177	1.000	Inparanoid score	I103
Isobase	1	0.950	-	0.8533	Normalized mean entropy	S129
OMA	1	1.010	-	-		QHG61250
OrthoDB	1	1.010	-	-		D101024at33208
OrthoFinder	1	1.000	-	-		FOG0003236
OrthoInspector	1	1.000	-	-		otm14358
orthoMCL	1	0.900	-	-		OOG6_101426
Panther	1	1.100	-	-	O	PTHR43160
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3169
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.860