DRSC/TRiP Functional Genomics Resources

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Protein Alignment mAcon2 and Aco1

DIOPT Version :9

Sequence 1:NP_650042.2 Gene:mAcon2 / 41326 FlyBaseID:FBgn0037862 Length:783 Species:Drosophila melanogaster
Sequence 2:NP_031412.2 Gene:Aco1 / 11428 MGIID:87879 Length:889 Species:Mus musculus


Alignment Length:914 Identity:246/914 - (26%)
Similarity:371/914 - (40%) Gaps:217/914 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 PYKKLRENLDCIK----------------GRLGGPLTLS--------------------EKVLYS 70
            |:..|.|.||..:                |||  |.::.                    |.:|..
Mouse     4 PFAHLAEPLDAAQPGKRFFNLNKLEDSRYGRL--PFSIRVLLEAAVRNCDEFLVKKNDIENILNW 66

  Fly    71 HLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQF--ISSGLKKV---------AVPSTVHC 124
            ::.|..:.|:.       .:|.||.|||.|....::.|  :...:||:         ..|:.:..
Mouse    67 NVMQHKNIEVP-------FKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVI 124

  Fly   125 DHLIEAQISGDKD-LARAKDL----NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILENYA--- 180
            ||.|:...:...| |.:.:||    |||.::||. .:.|..|:....||||||||:.||..|   
Mouse   125 DHSIQVDFNRRADSLQKNQDLEFERNKERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVV 189

  Fly   181 -------FPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHLTGKISG 238
                   :|..| :||||||....|||.|..||||.:|..||...|..:..|.|||..|.||...
Mouse   190 FDQDGCYYPDSL-VGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHP 253

  Fly   239 WTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPFNERMVT 303
            ..:..|::|.:.:.|...|..|..||:.||||..:|....|||.||..|.|||.:.||.:|..:.
Mouse   254 LVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIA 318

  Fly   304 YLRATGR---------------GAIADEATKNKDLLVPDEGCKYDKVIEINLDTLEPLVNGPFTP 353
            ||..|||               |...|....::|   ||    :.:|:|::|.|:.|..:||..|
Mouse   319 YLLQTGREEDKVKHIQKYLQAVGMFRDFNDTSQD---PD----FTQVVELDLKTVVPCCSGPKRP 376

  Fly   354 DLAHPISKLGQNSE-----KNGYP--------------------------MEIKVSLIGSCTNSS 387
            .....:|::.::.|     |.|:.                          ..:.::.|.||||:|
Mouse   377 QDKVAVSEMKKDFESCLGAKQGFKGFQVAPDRHNDRKTFLYSNSEFTLAHGSVVIAAITSCTNTS 441

  Fly   388 YEDM----GRCASIANDALGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGP 448
            ...:    |..|..|.:| |..:|..:..:::|||..|...:...|::..|.:.|..|:...|..
Mouse   442 NPSVMLGAGLLAKKAVEA-GLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMT 505

  Fly   449 CIGQWDR------KDVKMGEKNTI-VTSYNRNFTGRNDANPATHC-FVTSPEMATALAIAG--RL 503
            |||....      :.:..|:...: |.|.||||.||  .:|.|.. ::.||.:..|.||||  |:
Mouse   506 CIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTVRI 568

  Fly   504 DFN-------------------PMTDELTGTDGKTF---KLKEPHGE-ELPSKGFD----PGEDT 541
            ||.                   |..||:...:.:..   ..||.:.: |..:|.::    |.|..
Mouse   569 DFEKEPLGVNAQGRQVFLKDIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKL 633

  Fly   542 YQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGKCTTDHISAAG------P 600
            |...| |:..||.....:|..|.|..|      |..:|..||:.:....||||||.||      |
Mouse   634 YAWNP-KSTYIKSPPFFESLTLDLQPP------KSIVDAYVLLNLGDSVTTDHISPAGNIARNSP 691

  Fly   601 WLKY---RGHLDNISNN---------MFIGATNAENNEMNKVKNQKTGS------------FDAV 641
            ..:|   ||......|:         :....|.|....:||..|::...            ||| 
Mouse   692 AARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDA- 755

  Fly   642 PAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQGMLALT 706
               |..|:...:....:..:.||.||||:.||..|..||..|::.:|:.|||.:||...|::.|.
Mouse   756 ---AERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLE 817

  Fly   707 FANPG---DYDKVQPSSKISILNLKDLAPGKPVDAEIKNNGSSDKIQLNHTLNELQIQWFQAGSA 768
            :. ||   |...:....:.:|...:||.|...|..::....:...:....|  ::::.:|..|..
Mouse   818 YL-PGETADSLGLTGRERYTINIPEDLKPRMTVQIKLDTGKTFQAVMRFDT--DVELTYFHNGGI 879

  Fly   769 LNLM 772
            ||.|
Mouse   880 LNYM 883

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
mAcon2NP_650042.2 aconitase_mito 43..772 CDD:273561 244/911 (27%)
AcnA_Mitochondrial 93..503 CDD:153134 150/496 (30%)
Aconitase_swivel 585..733 CDD:294147 49/180 (27%)
Aco1NP_031412.2 PTZ00092 3..889 CDD:240263 246/914 (27%)
Substrate binding. /evidence=ECO:0000250 205..207 1/1 (100%)