DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mAcon2 and aco1

DIOPT Version :9

Sequence 1:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_012812984.1	Gene:	aco1 / 100216202	XenbaseID:	XB-GENE-1012108	Length:	917	Species:	Xenopus tropicalis

Alignment Length:	868	Identity:	243/868 - (27%)
Similarity:	356/868 - (41%)	Gaps:	203/868 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQF--ISSGLKKV-AVPSTVH--C 124
            |.:|...|.|.|:.|:.       .||.||.|||.|....::.|  :...:|:: ..|.|::  |
Frog    85 ENILNWKLTQHDNVEVP-------FRPARVILQDFTGVPAVVDFAAMRDAVKRLGGDPQTINPVC 142

  Fly   125 ------DHLIEAQISGDKD-LARAKDL----NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILE 177
                  ||.|:...:...| |.:.::|    |:|.::||. .:.|..|:....||||||||:.||
Frog   143 PVDLVIDHSIQVDFNRRSDSLQKNQELEFERNRERFEFLKWGSQAFQNMRIIPPGSGIIHQVNLE 207

  Fly   178 ----------NYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPTVIGCHL 232
                      .|.:|..| :||||||....|||.|..||||.:|..||...|..:..|.|||..|
Frog   208 YLARVVFDQDGYYYPDSL-VGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPEVIGYKL 271

  Fly   233 TGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGATTSIFPF 297
            .|......:..|::|.|.:.|...|..|..||:.|.||..:|....|||.||..|.|||.:.||.
Frog   272 MGNPHPLVTSTDIVLTVTKHLRQVGVVGKFVEFFGTGVAQLSIADRATIANMCPEYGATAAFFPV 336

  Fly   298 NERMVTYLRATGR---------------GAIADEATKNKDLLVPDEGCKYDKVIEINLDTLEPLV 347
            :...|.||:.|||               |...|....|:|   ||    :.:|:|::|.|:.|..
Frog   337 DLVSVQYLQQTGRAEEKVQYIQKYLEAAGLFRDFNNTNQD---PD----FSQVVELDLSTVVPCC 394

  Fly   348 NGPFTPDLAHPISKL---------------------GQNSEKNGYPM----------EIKVSLIG 381
            :||..|.....:|::                     |.:.:|..:|.          .:.::.|.
Frog   395 SGPKRPQDKVSVSEMKSDFQNCLGAKQGFKGFQIPQGHHYDKVKFPYNNTEYELSHGSVVIAAIT 459

  Fly   382 SCTNSSYED-MGRCASIANDALGHGL--KSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLA 443
            ||||:|... |.....:|..|:..||  |..:..:::|||..|...:...|:...|.|.|..|:.
Frog   460 SCTNTSNPSVMLGAGLLAKKAVEAGLCVKPYIKTSLSPGSGVVTFYLRDSGVQPYLSKLGFDVVG 524

  Fly   444 NACGPCIGQWDR------KDVKMGEKNTI-VTSYNRNFTGRNDANPATHC-FVTSPEMATALAIA 500
            ..|..|||....      :.:..|:...: |.|.||||.||  .:|.|.. ::.||.:..|.|||
Frog   525 YGCMTCIGNSGPLPDPVVEAITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIA 587

  Fly   501 G--RLDFN-------------------PMTDELTGTDGK-----TFK---------------LKE 524
            |  |:||.                   |..||:...:.:     .||               ||.
Frog   588 GTIRIDFEKDPLGVNAEGKEIYLRDIWPTRDEIQAVERQYVIPGMFKEVYEKIEKVNESWNDLKA 652

  Fly   525 PHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLMVLIKIKGK 589
            |..|..|   :|| :.||...|...|.:.:.:.|.               |...|..||:.:...
Frog   653 PTDELYP---WDP-KSTYIKSPPFFDSLTMELQPP---------------KSITDAYVLLNLGDS 698

  Fly   590 CTTDHISAAG------PWLKY---RGHLDNISNN---------MFIGATNAENNEMNKVKNQKTG 636
            .||||||.||      |..:|   ||......|:         :....|.|.....||..|:::.
Frog   699 VTTDHISPAGNIARNSPAARYLVNRGLTPREFNSYGSRRGNDAVMARGTFANIRLFNKFINKQSP 763

  Fly   637 S------------FDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSF 689
            |            |||    |..|:.:......:..:.||.||||:.||..|...|..|::.:|:
Frog   764 STIYFPSNETLDIFDA----AERYQNDGHNLILLTGKEYGSGSSRDWAAKGPFLQGIKAVLAESY 824

  Fly   690 ARIHETNLKKQGMLALTFANPGDYDKV-----QPSSKISILNLKDLAPGKPVDAEIKNNGSSDKI 749
            .|||.:||...|::.|.:. ||:..:.     |....|.|...|||.||..|:.::....|.:.|
Frog   825 ERIHRSNLVGMGIIPLQYL-PGESAEALGLSGQERYTIVIPEEKDLRPGMNVEIKLDTGKSFEAI 888

  Fly   750 QLNHTLNELQIQWFQAGSALNLM 772
            ....|  ::::.:::.|..||.|
Frog   889 MRFDT--DVELTYYRNGGILNYM 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	242/866 (28%)
		AcnA_Mitochondrial	93..503	CDD:153134	150/495 (30%)
		Aconitase_swivel	585..733	CDD:294147	51/182 (28%)
aco1	XP_012812984.1	PTZ00092	26..916	CDD:240263	243/868 (28%)
		AcnA_IRP	106..590	CDD:153136	150/493 (30%)
		AcnA_IRP_Swivel	694..863	CDD:238812	47/173 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010