Protein Alignment Tengl4 and ENDOG

DIOPT Version :10

• Sequence 1: NP_650038.2
• Gene: Tengl4 / 41321
• FlyBaseID: FBgn0037857
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_004426.2
• Gene: ENDOG / 2021
• HGNCID: 3346
• Length: 297
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 86/283 - (30%)
• Similarity: 130/283 - (45%)
• Gaps: 31/283 - (10%)

  Fly    79 ESGTSKRYSERQDPGSVSIFEHFLLWGRRKAHNAISKMTLSVGPNGSRHENIEHVADIMKYGFPG 143
            |....:|...|..||         |.||.......:...|...|.|.|..     .::.|||.||
Human    21 EGWRRRREDARAAPG---------LLGRLPVLPVAAAAELPPVPGGPRGP-----GELAKYGLPG 71

  Fly   144 MDEIHVYKNFVLSYDRRNRIAHWVCEHVK------SGCVQERDEKTLNKPNAYITDNTIPTIFSA 202
            :.::...:::||.||.|.|.|.||.|.::      .|..:|.|         :..|:::.....|
Human    72 LAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECD---------FREDDSVHAYHRA 127

  Fly   203 NMRDFKNSDWVGGHLASPQNYKCDALKFLEAYKFTNIVPINRGLKNHIWYRLESYVRDKAIEFDS 267
            ...|::.|.:..||||:..|::.......:.:..:|:.|....|..:.|..||.|.|.....:.:
Human   128 TNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRSYQN 192

  Fly   268 VHVYTGPLFMPQRITFRNWSVRYHVMGMNTVAVPTHFFKIIIREDEFNRDMPIMEGYVVPNAYVD 332
            |:|.|||||:|:........|:|.|:|.|.|||||||||::|.|....:..  :..||:|||.||
Human   193 VYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIE--LRTYVMPNAPVD 255

  Fly   333 KDMDLRSFLADVRDIEHFAGLKF 355
            :.:.|..||..:..||..:||.|
Human   256 EAIPLERFLVPIESIERASGLLF 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tengl4	NP_650038.2	Endonuclease_NS	132..362	CDD:460120	74/230 (32%)
ENDOG	NP_004426.2	NUC	78..284	CDD:214683	69/212 (33%)
		Essential for deoxyribonuclease activity. /evidence=ECO:0000250|UniProtKB:O08600	286..296