Protein Alignment Leash and ARRDC1

DIOPT Version :9

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_006717383.1
• Gene: ARRDC1 / 92714
• HGNCID: 28633
• Length: 466
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 117/513 - (22%)
• Similarity: 187/513 - (36%)
• Gaps: 155/513 - (30%)

  Fly    42 VQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVA 106
            ::||..|.|.    :...:|:..      :..:|.|.:|...|.|   :| .|.||||:|.|:..
Human    48 IRVTCIGSCG----VSNKANDTA------WVVEEGYFNSSLSLAD---KG-SLPAGEHSFPFQFL 98

  Fly   107 LGRQLPSSFKGSYGAIKYKMRVLIQRP-WTFDERHTIPFTV-----------VKNMPLQPMQRSI 159
            |....|:||:|.:|.|.:::|..|..| ::.|.:.::.|.:           ::...|:...:.:
Human    99 LPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEGSSLRTPAKPL 163

  Fly   160 PSSLEKQ-----VTKTIS--LFGTRPITLLALLPEDFAVRGEPLRICATVINNSTTAVEKLRFTV 217
            |....||     .||..|  |..|..:.|.|.......|.|:.|::.|.|.|.|......:..::
Human   164 PGPPPKQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVGQALQLHADVENQSGKDTSPVVASL 228

  Fly   218 LQYVTY----YSHVPLRVQKVECIAVATKETGSVQKKTERSFAHELL----LPDGAQPTDEQMSG 274
            ||.|:|    :.|....:.:||         |:..|...|:..||.:    ||..|.|.    ..
Human   229 LQKVSYKAKRWIHDVRTIAEVE---------GAGVKAWRRAQWHEQILVPALPQSALPG----CS 280

  Fly   275 VITIVYELRVE-------AVLRGFFKNLILNLPFKVYSQDPSNRQSSLRPPPPPRPNDG-PPGPE 331
            :|.|.|.|:|.       ..|..|..|:.:|                 ..|..|||..| ||
Human   281 LIHIDYYLQVSLKAPEATVTLPVFIGNIAVN-----------------HAPVSPRPGLGLPP--- 325

  Fly   332 LGSGNLFEPALPVY--PSLDSSIGSP-----------SHSSQFSECSSINSI-------TSDSSA 376
             |:..|..|:.|..  ...:::.|.|           |||.:....::::|:       ..|.|.
Human   326 -GAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCPQDGSP 389

  Fly   377 AT--LSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYPPPHLP- 438
            |:  |.|.:...||.....:..||     |.|             :|.:|:.::    ||.:..
Human   390 ASHPLHPPLCISTGATVPYFAEGS-----GGP-------------VPTTSTLIL----PPEYSSW 432

  Fly   439 AYPPPESPQYSLLALTPPPAGVVAAPPTGGAAAGGAPAYSQLPSTSASASFLQPRQAP 496
            .||..||                    |..|..||       .:.|.:.:.|..|:.|
Human   433 GYPYGES--------------------TARAWQGG-------DAKSPTQTLLSSRRGP 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	30/121 (25%)
		Arrestin_C	178..305	CDD:280848	34/141 (24%)
ARRDC1	XP_006717383.1	Arrestin_N	<70..146	CDD:304627	25/79 (32%)
		Arrestin_C	186..307	CDD:280848	33/133 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920