Protein Alignment Leash and CSR2

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_015355.1
• Gene: CSR2 / 856142
• SGDID: S000006234
• Length: 1121
• Species: Saccharomyces cerevisiae
• Alignment Length: 563
• Identity: 92/563 - (16%)
• Similarity: 176/563 - (31%)
• Gaps: 221/563 - (39%)

  Fly    30 NVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNE--YS-RSLFYTSKE------VYEHSETPLP 85
            ::||.|.:..|||::|...:..|...|....|.||  |: .||.:|...      :.:.:::||.
Yeast   359 SLNKSTTLSDIKVELTSNVRVVWFNGLPPTKNVNEECYNIGSLDWTLNADNFNLFIPQGAKSPLD 423

  Fly    86 -----------------------DFEPRGL----------------ELSAGEHTFIFEVALGRQL 111
                                   .|..:.:                :|:||.:.|...:.|..::
Yeast   424 IVENHSNNRKLKVLQKLSMRKRRSFSNKAVLRENILNNLNASNSTNKLNAGVYVFTIPIVLASRI 488

  Fly   112 PSSFKGSYGAIKYKMRVLIQ------------------------RPWTFDERH-------TIPFT 145
            |.|.......:.|.:|:..:                        |.::..:.:       ||...
Yeast   489 PESLYYPSARVSYSLRLATKLKDEHTQLVASRPRSSSISSPQKLRSYSCSDSYEYSQIDDTIEGE 553

  Fly   146 VVKNMPLQPMQRSIPSS-----------------------------LEKQVTKTISLFGTRPITL 181
            ...|......:.:.|||                             ::.....||:|  ..|:.|
Yeast   554 TYNNDKNSTGKIAFPSSWLKSAKGRLKRNNSNGRSDNNGASSSGLAMQHDSEDTINL--QYPLNL 616

  Fly   182 LALLPE-DFAVRGEPL---RICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQ--------KV 234
            :...|| ......:||   ::....::...:..:|       ||.....:|:.::        .|
Yeast   617 VRTPPEISVTTANKPLYINKVWENCLSYEISFAQK-------YVPLNGEIPITIKVAPLVKSLSV 674

  Fly   235 ECIAVATKETGSVQKKTERSFAHELLLPDGAQPTDE------------------QMSGVITIVYE 281
            :.|.|:.:|..|.:.| :..:..:.|.|..:.|.:.                  :::...|....
Yeast   675 KRIRVSCREKISYRSK-DYQYDFDQLDPLASDPCNPYHMRYLVRKKKDRSLPLFEVASKCTSGPS 738

  Fly   282 LRVEAVLRGFFKNLI---------------------LNLPFKVYSQDPSNRQSSLRPPPPPRPND 325
            :|.|.|......||:                     ..|.|..|.:..:.:.:||    ||...|
Yeast   739 IREEVVTNTVDDNLLAYTSSKENNKDIPFSESFTVKTKLKFPKYCEVDATKAASL----PPYGID 799

  Fly   326 GPPGPELGSGNLFEPALPVYPSLDSS---------IGSPSHSSQFSECSSINSITSDSSAATLSP 381
                       ||:|......|.::|         :|.|:.:|:     :::.|..|.:
Yeast   800 -----------LFDPIKDPTQSENTSNNGNVLGFLVGRPNRASK-----TVHKIPQDKN------ 842

  Fly   382 AVGAGTGGMDMSYTSGSQSSQYGSPSARTSLR-SSNVPYMPYS 423
                   ..:::.|:|         ::.|||: |||||...|:
Yeast   843 -------HNEVNDTNG---------NSNTSLQTSSNVPIQHYT 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	32/200 (16%)
		Arrestin_C	191..308	CDD:214976	24/166 (14%)
CSR2	NP_015355.1	Arrestin_C	638..>737	CDD:214976	14/106 (13%)
		Arrestin_C	<828..926	CDD:214976	14/69 (20%)