Protein Alignment Leash and ROD1

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_014661.1
• Gene: ROD1 / 854183
• SGDID: S000005544
• Length: 837
• Species: Saccharomyces cerevisiae
• Alignment Length: 754
• Identity: 123/754 - (16%)
• Similarity: 226/754 - (29%)
• Gaps: 292/754 - (38%)

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRK-NSNNNEYSRSLFYTSK 74
            |.|..|..:|.|:     :::.:..:|:::.:::.|:.:.....:|:. :..:..||:    ..:
Yeast    34 DEASSVLLSGTIV-----LSITEPIQIKSLALRLFGRLRLNIPTVLQTVHGPHKRYSK----FER 89

  Fly    75 EVYEH----------------------------SETPLPDFEPRGLELSA--------------- 96
            .:|.|                            |.|.|.....|...||.
Yeast    90 NIYSHFWDDFNIKSYFQNLYDNHNNGKITISSKSSTNLAALPKRKRALSTASLISSNGQTSASKN 154

  Fly    97 ------GEHTFIFEVALGRQLPSSFKG-SYGAIKYKMRVLIQRPWTFD---ERHTIPFTVVKNMP 151
                  |.:.|.|...:...|..|.:| ...|:.|.:...|:||...|   ::|   ..|::.:.
Yeast   155 YHTLVKGNYEFPFSAIIPGSLVESVEGLPNAAVTYALEATIERPKQPDLICKKH---LRVIRTLA 216

  Fly   152 LQPMQR----SIPSSLEKQVTKTISL------FGTRPITLLALLPEDFAVRGEPLRICATVINNS 206
            :..::.    |:.:|..::|..|||:      .|:..:..:.::|....::..|:||  :::.||
Yeast   217 IDAVELSETVSVDNSWPEKVDYTISIPTKAIAIGSSTMINILIVPILKGLKLGPVRI--SLVENS 279

  Fly   207 TTAVEKLRFTVLQYVTYYSHV--------------PLR----VQKVECIAVATKE-----TGSVQ 248
                        ||...|..|              ||:    ::|...:..|..|     ||..|
Yeast   280 ------------QYCGSYGGVINQERMVAKLKLKDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQ 332

  Fly   249 KKTE-----------------------------RSFAHELLLPDG-----------------AQP 267
            .|.|                             ..|...||.|||                 ..|
Yeast   333 DKWEVRALLNIPASLTKCSQDCRILSNIKVRHKIKFTISLLNPDGHISELRAALPVQLFISPFVP 397

  Fly   268 TDEQMSGVI--------------------------------TIVYELRVEAVLRGFFKNLILNLP 300
            .:.:.|.||                                .::::....|:.......::....
Yeast   398 VNVKTSDVIERTLKTFGPSYQVTSQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGST 462

  Fly   301 FKVYSQD-------PSNRQSSLRPPP-----------PPRPNDGPPGPELGSG-----------N 336
            ..:.|.|       .:...:||..||           ....|:........|.           |
Yeast   463 LNINSTDAEATAVADTTMVTSLMVPPNYGNHVYDRVYGEVTNEDETSASASSSAVESQAIHNIQN 527

  Fly   337 LF--------EPALPVYPSL---DSSIGSPSHSSQFSECSSINSITSD-----------SSAATL 379
            |:        .|.|...|.:   |.|:.:..........|::|.:.|:           .||...
Yeast   528 LYISDSNNSNNPILAPNPQIKIEDDSLNNCDSRGDSVNNSNLNLVNSNLTISENWNNNSPSANRY 592

  Fly   380 SPAVGAGTGGMDM--SYTSGSQSSQYGSPSARTSLRS-------SNVP-YMPYSSSPLMVQSYPP 434
            :..:.||.....:  |:...|:.:.|...::.|||::       |.|| |.....|.::.:..|
Yeast   593 NNIINAGLNSPSLTPSFAHLSRRNSYSRQTSSTSLKNDLELTDLSRVPSYDKAMKSDMIGEDLP- 656

  Fly   435 PHLPAYPPP------------ESPQY----SLLALTPPPAGVVAAPPTGGAAAGGAPAYSQLP-- 481
               ||||..            |.||.    |..:|.|.|....::.....:::....::|.||
Yeast   657 ---PAYPEEELGVQENKKIELERPQILHHKSTSSLLPLPGSSKSSNNLKRSSSRTHLSHSPLPRN 718

  Fly   482 ------------------STSASASFLQPRQAPGAHELP 502
                              |.:.:.||...:.:.|:...|
Yeast   719 NSGSSVSLQQLARNNTDSSFNLNLSFTSAKSSTGSRHFP 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	32/194 (16%)
		Arrestin_C	191..308	CDD:214976	32/224 (14%)
ROD1	NP_014661.1	Arrestin_N	<157..215	CDD:451447	14/60 (23%)
		Arrestin_C	232..395	CDD:214976	31/176 (18%)