DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and ROD1

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_014661.1	Gene:	ROD1 / 854183	SGDID:	S000005544	Length:	837	Species:	Saccharomyces cerevisiae

Alignment Length:	754	Identity:	123/754 - (16%)
Similarity:	226/754 - (29%)	Gaps:	292/754 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRK-NSNNNEYSRSLFYTSK 74
            |.|..|..:|.|:     :::.:..:|:::.:::.|:.:.....:|:. :..:..||:    ..:
Yeast    34 DEASSVLLSGTIV-----LSITEPIQIKSLALRLFGRLRLNIPTVLQTVHGPHKRYSK----FER 89

  Fly    75 EVYEH----------------------------SETPLPDFEPRGLELSA--------------- 96
            .:|.|                            |.|.|.....|...||.
Yeast    90 NIYSHFWDDFNIKSYFQNLYDNHNNGKITISSKSSTNLAALPKRKRALSTASLISSNGQTSASKN 154

  Fly    97 ------GEHTFIFEVALGRQLPSSFKG-SYGAIKYKMRVLIQRPWTFD---ERHTIPFTVVKNMP 151
                  |.:.|.|...:...|..|.:| ...|:.|.:...|:||...|   ::|   ..|::.:.
Yeast   155 YHTLVKGNYEFPFSAIIPGSLVESVEGLPNAAVTYALEATIERPKQPDLICKKH---LRVIRTLA 216

  Fly   152 LQPMQR----SIPSSLEKQVTKTISL------FGTRPITLLALLPEDFAVRGEPLRICATVINNS 206
            :..::.    |:.:|..::|..|||:      .|:..:..:.::|....::..|:||  :::.||
Yeast   217 IDAVELSETVSVDNSWPEKVDYTISIPTKAIAIGSSTMINILIVPILKGLKLGPVRI--SLVENS 279

  Fly   207 TTAVEKLRFTVLQYVTYYSHV--------------PLR----VQKVECIAVATKE-----TGSVQ 248
                        ||...|..|              ||:    ::|...:..|..|     ||..|
Yeast   280 ------------QYCGSYGGVINQERMVAKLKLKDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQ 332

  Fly   249 KKTE-----------------------------RSFAHELLLPDG-----------------AQP 267
            .|.|                             ..|...||.|||                 ..|
Yeast   333 DKWEVRALLNIPASLTKCSQDCRILSNIKVRHKIKFTISLLNPDGHISELRAALPVQLFISPFVP 397

  Fly   268 TDEQMSGVI--------------------------------TIVYELRVEAVLRGFFKNLILNLP 300
            .:.:.|.||                                .::::....|:.......::....
Yeast   398 VNVKTSDVIERTLKTFGPSYQVTSQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGST 462

  Fly   301 FKVYSQD-------PSNRQSSLRPPP-----------PPRPNDGPPGPELGSG-----------N 336
            ..:.|.|       .:...:||..||           ....|:........|.           |
Yeast   463 LNINSTDAEATAVADTTMVTSLMVPPNYGNHVYDRVYGEVTNEDETSASASSSAVESQAIHNIQN 527

  Fly   337 LF--------EPALPVYPSL---DSSIGSPSHSSQFSECSSINSITSD-----------SSAATL 379
            |:        .|.|...|.:   |.|:.:..........|::|.:.|:           .||...
Yeast   528 LYISDSNNSNNPILAPNPQIKIEDDSLNNCDSRGDSVNNSNLNLVNSNLTISENWNNNSPSANRY 592

  Fly   380 SPAVGAGTGGMDM--SYTSGSQSSQYGSPSARTSLRS-------SNVP-YMPYSSSPLMVQSYPP 434
            :..:.||.....:  |:...|:.:.|...::.|||::       |.|| |.....|.::.:..|
Yeast   593 NNIINAGLNSPSLTPSFAHLSRRNSYSRQTSSTSLKNDLELTDLSRVPSYDKAMKSDMIGEDLP- 656

  Fly   435 PHLPAYPPP------------ESPQY----SLLALTPPPAGVVAAPPTGGAAAGGAPAYSQLP-- 481
               ||||..            |.||.    |..:|.|.|....::.....:::....::|.||
Yeast   657 ---PAYPEEELGVQENKKIELERPQILHHKSTSSLLPLPGSSKSSNNLKRSSSRTHLSHSPLPRN 718

  Fly   482 ------------------STSASASFLQPRQAPGAHELP 502
                              |.:.:.||...:.:.|:...|
Yeast   719 NSGSSVSLQQLARNNTDSSFNLNLSFTSAKSSTGSRHFP 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	32/194 (16%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	31/227 (14%)
ROD1	NP_014661.1	Arrestin_N	<157..215	CDD:419887	14/60 (23%)
ROD1	NP_014661.1	Arrestin_C	232..395	CDD:214976	31/176 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840