DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Leash and RIM8

DIOPT Version :9

Sequence 1:NP_650037.2 Gene:Leash / 41320 FlyBaseID:FBgn0037856 Length:520 Species:Drosophila melanogaster
Sequence 2:NP_011470.4 Gene:RIM8 / 852837 SGDID:S000003013 Length:542 Species:Saccharomyces cerevisiae


Alignment Length:545 Identity:112/545 - (20%)
Similarity:191/545 - (35%) Gaps:134/545 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ERLRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQV------------TGKGKCKWMEIL 56
            ::.||.:|...||:...:.|.||..:::.:.....|||:.:            |.|.| :..:.|
Yeast    37 KQFRIDIDEPHRVWKPNESITGEAVIDIKRDITNVAIKLSLVCEVRVKTGNSPTSKNK-RIEKTL 100

  Fly    57 RKNS--NNNEYSRSLFYTSKEVYEH-SETPLPDFEPRGLELSAGEHTFIFEVAL--GRQLPSSFK 116
            .|::  ...:|.::.| ::||...| .:|.:.:      .||.|||.|.|.:.:  ||.:.||.|
Yeast   101 EKSTFLYGQDYVKTAF-SAKEKKPHVDKTTILN------GLSKGEHRFPFRIRIPRGRGMLSSIK 158

  Fly   117 GSYGAIKYKMRVLIQ---------RPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTIS 172
            ...|:|.|.:...::         :|....||.   |.|:  :||.      .|.|.|..|||:.
Yeast   159 FERGSITYFLSCTLESLNNINGLKKPEARCERE---FAVI--VPLD------VSRLPKPKTKTVV 212

  Fly   173 LFGTRPI-------TLLALLPEDFAVRGEPLRICATVINNSTTAVEK------------------ 212
            |.....:       |      ||.:.....|...:|..|:|:::|..                  
Yeast   213 LQSASMVQNKKNKST------EDESSSYTQLTQKSTTSNSSSSSVNSKTSPLPNKTVTISVDIPQ 271

  Fly   213 ----------LRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQK----KTERSFAHELLLPD 263
                      :...:..|..:|:...|....|....|     |...|    :|.|....:.:.|.
Yeast   272 AGFMIGEIIPIDVKIDHYKPFYAPAGLTTTLVRICRV-----GGAGKDDPMETFRKDICQSISPI 331

  Fly   264 GAQPTDEQMSGVITIVYELRVEAVLR--------GFFKNLILNLPFK--VYSQDPSNRQSSLRPP 318
            ...|...|....:.:...|...:.|.        .::..:::||..|  ||::  |||....   
Yeast   332 YINPETLQFQSRVYLKVPLDAFSTLTTVGKFFSFQYYIEVMVNLSKKNVVYTE--SNRIIGT--- 391

  Fly   319 PPPRPNDGPPGPELGSG-----NLFEPAL--PVYP-SLDSSIGSPSHSSQFSECSSINSITSDSS 375
                    |.|.:.|.|     |..:..:  .|.| :|::.......|..|.:..::..:....:
Yeast   392 --------PIGEQNGLGVENNINRIQRKMLRMVNPETLENDSEGYESSIFFKDMVNVEKLKRLRN 448

  Fly   376 AATLSPAVGAGTGGMDMSYTSG---SQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYPPPHL 437
            ...:|.....||...:...:..   ||||.....::.::||....|...|.|..:.|..|.|...
Yeast   449 VTGMSIETVIGTTRSEQQQSDASIPSQSSITAPQNSPSNLRDWLAPLNAYDSDDVPVPKYSPNDK 513

  Fly   438 PAYPPP-----ESPQYSLLALTPPP 457
            .:.|..     |..:...|...|||
Yeast   514 VSVPSEDKQELEQKRLQQLESDPPP 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LeashNP_650037.2 Arrestin_N 6..152 CDD:304627 42/171 (25%)
Arrestin_C 178..305 CDD:280848 26/175 (15%)
RIM8NP_011470.4 Arrestin_N 39..201 CDD:419887 44/180 (24%)
Arrestin_C 259..392 CDD:397050 22/150 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11188
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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