DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and ECM21

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_009449.1	Gene:	ECM21 / 852173	SGDID:	S000000197	Length:	1117	Species:	Saccharomyces cerevisiae

Alignment Length:	607	Identity:	113/607 - (18%)
Similarity:	196/607 - (32%)	Gaps:	219/607 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SNNNEYSRSLFY---TSKEVY--------------EHSETPLPDFEPRGLELSAGEHTFIFEVAL 107
            :|:|:....||.   |.:.:|              :.::|.|  ::|       |::.|:..|..
Yeast   399 NNSNDRQMRLFKNIPTEERLYLDKTKTKASLLNAIDVNKTHL--YQP-------GDYVFLVPVVF 454

  Fly   108 GRQLPSSFKGSYGAIKYKMRV---LIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLE----- 164
            ...:|.:.......:.|::|:   .|.|...:.:....|..:|.......:. |..|||:
Yeast   455 SNHIPETIYLPSARVSYRLRLATKAINRKGFYRQDSNSPQPIVSPDSSSSLS-STTSSLKLTETE 518

  Fly   165 -----KQVTKTI-----------------------SLFGTRPITLLALLPEDFAV--RGEPLRIC 199
                 ::::.|:                       .:|...||.::. .|...||  ..:|:
Yeast   519 SAQAHRRISNTLFSKVKNHLHMSSHQLKNEESGEEDIFAEYPIKVIR-TPPPVAVSTANKPI--- 579

  Fly   200 ATVINNSTTAVEKLRFTV---LQYVTYYSHVPLRVQ-----KVECI----AVATKETGSVQKKTE 252
              .||...|  :.|.:.:   .:||:..|.||::::     |..|:    ...|:....|.|..|
Yeast   580 --YINRVWT--DSLSYEISFAQKYVSLNSEVPIKIKLAPICKNVCVKRIHVSITERVTFVSKGYE 640

  Fly   253 RSFAHELLLPDGAQPTD------------EQMSGVITI------VYELRVEAVLRGFFKNLILNL 299
              :.::...|....|.:            |:...:..|      ...||.|.|...|..||:...
Yeast   641 --YEYDQTDPVAKDPYNPYYLDFASKRRKERSVSLFEIRTKEKGTRALREEIVENSFNDNLLSYS 703

  Fly   300 PFKVYSQDPSNRQSSLRPPPPPRPNDGPPGPELGSGNLFEPAL-------PVYPSLD-------- 349
            ||    .|.|:             :.|.|...||   :.||.:       |.|..||
Yeast   704 PF----DDDSD-------------SKGNPKERLG---ITEPIIIETKLKFPKYEDLDKRTAKIIP 748

  Fly   350 -------SSIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQS------- 400
                   :||.:|.|:            .::..:......:|.      :|...||:|
Yeast   749 PYGIDAYTSIPNPEHA------------VANGPSHRRPSVIGF------LSGHKGSKSHEENEKP 795

  Fly   401 ------------SQYGSPSART--------------SLRSSNVPYMPYSSSPLMVQSYPPPHLPA 439
                        |..|.| .:|              ||..||| |..:....::..|.|.|..|:
Yeast   796 VYDPKFHQTIIKSNSGLP-VKTHTRLNTPKRGLYLDSLHFSNV-YCRHKLEIMLRISKPDPECPS 858

  Fly   440 YPPPESPQYSLLALTP-------PPAGVVAAPPTGGAAAGGAPAYSQLPSTSASASFLQPRQAPG 497
                :...|.:|..||       ..:|.:..|....|...|..  :|:| .|.::.|......|
Yeast   859 ----KLRHYEVLIDTPIFLVSEQCNSGNMELPTYDMATMEGKG--NQVP-LSMNSDFFGNTCPP- 915

  Fly   498 AHELPPSYEELFGLANAPPGTP 519
                ||::||...:..:|..:|
Yeast   916 ----PPTFEEAISVPASPIVSP 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	19/111 (17%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	34/158 (22%)
ECM21	NP_009449.1	Arrestin_C	585..>648	CDD:214976	13/66 (20%)
ECM21	NP_009449.1	Arrestin_C	<781..878	CDD:413500	22/102 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930