Protein Alignment Leash and ROG3

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_116677.3
• Gene: ROG3 / 850578
• SGDID: S000001918
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 606
• Identity: 118/606 - (19%)
• Similarity: 197/606 - (32%)
• Gaps: 182/606 - (30%)

  Fly    28 WMNVNKRTKIRAIKVQVTGKGKCKWMEIL--RKNSNNNEYSRSLFYTSKEVYEHSETPLPDFEPR 90
            |.|||.:..:..::.|....|......||  |:.:.:....:||..:|              .|.
Yeast   103 WDNVNLKEYLSGLRGQSGLAGSSSSSNILGTRQRAQSTSSLKSLKGSS--------------SPS 153

  Fly    91 GLELSAGEHTFIFEVALGRQLPSSFKGSYGA-IKYKMRVLIQRPWTFDERHTIPFTVVKNMPLQP 154
            ...|..|.:.|.|...|...||.|.:..... :.|.|..:|:|...:.:       ::....::.
Yeast   154 SCTLDKGNYDFPFSAILPGSLPESVESLPNCFVTYSMESVIERSKNYSD-------LICRKNIRV 211

  Fly   155 MQRSIPSSLEKQVTKTISLFGTRP--ITLLALLPEDFAVRGEPLRICATVINNSTTAVEK-LRFT 216
            ::...|:::|  :::|:.:..:.|  :.....:|......|.     ||.||.|...:.| |:..
Yeast   212 LRTISPAAVE--LSETVCVDNSWPDKVDYSISVPNKAVAIGS-----ATPINISIVPLSKGLKLG 269

  Fly   217 VLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHELLLPDGAQPTDEQMSGVITIVY- 280
            .::.|.:.::     |..:.......|...|.         ||.|.|....:..:.:|....|.
Yeast   270 SIKVVLFENY-----QYCDPFPPVISENRQVT---------ELNLEDPLNESSGEFNGNGCFVNN 320

  Fly   281 -----------ELRVEAVLRGFFKNLILN----------------LPFKVYSQDPSNRQSSLRPP 318
                       :..::.:|:  ..|.:.|                |.|.:...:|...:|.||..
Yeast   321 PFFQPDHSFQDKWEIDTILQ--IPNSLSNCVQDCDVRSNIKVRHKLKFFIILINPDGHKSELRAS 383

  Fly   319 PPPRPNDGP-------PGPELGSGNLFEPALPVYPSLDSSIGSPSHSSQ--------FSECSSIN 368
            .|.:....|       |   |.|.||:        ||.|:......:|.        ||..:|:.
Yeast   384 LPIQLFISPFVALSIKP---LSSSNLY--------SLFSTTNQKDENSSQEEEEEYLFSRSASVT 437

  Fly   369 SI------TSDSSAATLSPAVGAGTGGM---DMSY----------TSGS-----------QSSQY 403
            .:      .|..|..|:|..:......|   |..|          |||:           :..|.
Yeast   438 GLELLADMRSGGSVPTISDLMTPPNYEMHVYDRLYSGSFTRTAVETSGTCTPLGSECSTVEDQQQ 502

  Fly   404 GSPSAR---TSLRS--SNVPYMPYSSSPLMVQSYPPPHLPAYPPPES------PQYSLLALTPPP 457
            .....|   |.:|:  .|:...|.:||....:|..|  |...|.||.      ||.:|    .|.
Yeast   503 DLEDLRIRLTKIRNQRDNLGLPPSASSAAASRSLSP--LLNVPAPEDGTERILPQSAL----GPN 561

  Fly   458 AGVVAAPPTGGAAAGGAPA-YSQLPSTSASASFLQP-------------RQAPG----------A 498
            :|.|.     |..:..:|. .|:.|:.|.||..:.|             .:.|.          .
Yeast   562 SGSVP-----GVHSNVSPVLLSRSPAPSVSAHEVLPVPSGLNYPETQNLNKVPSYGKAMKYDIIG 621

  Fly   499 HELPPSYEELFGLANAPPGTP 519
            .:|||||.  ..:.|..|..|
Yeast   622 EDLPPSYP--CAIQNVQPRKP 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	25/126 (20%)
		Arrestin_C	191..308	CDD:214976	23/145 (16%)
ROG3	NP_116677.3	Arrestin_N	<156..215	CDD:451447	12/65 (18%)
		Arrestin_C	232..393	CDD:214976	30/181 (17%)