DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and si:ch211-130m23.2

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001108161.1	Gene:	si:ch211-130m23.2 / 794173	ZFINID:	ZDB-GENE-060531-13	Length:	441	Species:	Danio rerio

Alignment Length:	538	Identity:	109/538 - (20%)
Similarity:	191/538 - (35%)	Gaps:	147/538 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNS---NNNE--YSRSLFYT- 72
            :..:.:||.|.|::.::|.|.|:::::.|::.||....|.|...|.:   ::.|  ||...|:.
Zfish    18 NNTFTSGDYISGQVILDVVKDTQMQSLSVKIKGKANVCWSEHYGKTTVCYSDKEKFYSVERFFVR 82

  Fly    73 --SKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQ-LPSSFKGSYGAIKYKMRVLIQRPW 134
              :|:..:|.....|..:|....::.|.|.:.|...|..| .|||.|||.|.:.|.:...:.|..
Zfish    83 TDTKQGTDHEMLKDPSGQPYSSVVAPGRHLYPFTFQLPLQHFPSSLKGSVGKVLYTLETKLCRSL 147

  Fly   135 TFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQ---VTKTISLFGTRPITLLALLPEDFAVRGEPL 196
            ....:....|..|.:..:     |.|..:..|   :.|.:..|.:..:::.....:.....||.|
Zfish   148 RVSSKAKAEFNYVPSADI-----SNPELMAPQYGTIDKQMKFFNSGNVSMNISTEKMAYYLGEGL 207

  Fly   197 RICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETG-SVQKKTERSFAHELL 260
            ::.|. |:|.::.:.|.::.:.:..::::....::...:.:    ||.| ||:..::::....|.
Zfish   208 KVLAE-IHNGSSRIIKPKYCLYEKYSFFAKGRRKIHTHDLL----KEVGESVEPNSKKTITTVLT 267

  Fly   261 LPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPSNRQSSLRPPPPPRPND 325
            :|.....:..... ::.:.|.|||...::              |:.||
Zfish   268 IPPSLTASILNCR-ILKVEYRLRVYLDVK--------------YASDP----------------- 300

  Fly   326 GPPGPELGSGNLFEPALPVYPSLDSSIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAGTGGM 390
                         |..||:.                              ...|.|..||
Zfish   301 -------------EIKLPIV------------------------------VLPLQPVSGA----- 317

  Fly   391 DMSYTSGSQSSQYG-------------SPSARTSLRSSNVPYMPYSSSPLMVQSYPPPHL----- 437
                 :||..|.:|             .|....|.:|.|:...|   ..|....||.|.:
Zfish   318 -----NGSTKSDFGIWNQPQPGSAGPNPPPTAPSAQSQNIAGPP---GQLGAPDYPGPPVGQFSP 374

  Fly   438 PAYPPPESPQYSLLALTPPPAGVVAAPPTGGAAAGGAPAYSQLPSTSASASFLQPRQAPGAHELP 502
            |:||.|...|:..||. |.|.|..|.....||.....|:.:...||||                |
Zfish   375 PSYPGPPLDQFGALAF-PGPPGQSAPSYYSGAPGQFGPSVTHQSSTSA----------------P 422

  Fly   503 PSYEELFGLANAPPGTPK 520
            |.|:| |.|....|..|:
Zfish   423 PPYQE-FKLYPQLPDQPE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	37/146 (25%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	18/127 (14%)
si:ch211-130m23.2	NP_001108161.1	Arrestin_N	16..166	CDD:304627	37/152 (24%)
		Arrestin_C	187..309	CDD:280848	24/201 (12%)
		Collagen	333..408	CDD:189968	22/78 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579453
Domainoid	1	1.000	65	1.000	Domainoid score	I10015
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750