DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Leash and arrdc2

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_012821263.1	Gene:	arrdc2 / 780156	XenbaseID:	XB-GENE-946088	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	402	Identity:	102/402 - (25%)
Similarity:	159/402 - (39%)	Gaps:	99/402 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LRITLD---SADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSR 67
            :..:||   |..:||.||:|:.|::.:.:.|..::.|::|...|.....|:| .|....|..||.
Frog    25 ISFSLDLSPSVHKVYSAGEIVEGKVVLELCKELRVSALEVCGRGLATVHWLE-SRSVGMNTVYSD 88

  Fly    68 SLFYTSKEVY----EH------SETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAI 122
               :||.|.|    :|      :.|.||          ||.|.|.|...|...|.:||:|.:|::
Frog    89 ---FTSYETYLRKRQHLIRDNGTLTMLP----------AGRHEFPFSFQLPETLVTSFEGKHGSV 140

  Fly   123 KYKMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQ-------------------VT 168
            :|.::..:.|||...::....|||:     :|:..:.|..|..|                   ||
Frog   141 RYWVKAKLHRPWCTVKKVKKEFTVI-----EPIDINTPDLLAPQAGSKEKIAHAWYCNLGHVSVT 200

  Fly   169 KTISLFGTRPITLLALLPEDFAVRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQK 233
            ..|...|..|              ||.:.|.|.:.|.:|.||.. :..::|...:.:...::.:|
Frog   201 AKIDRKGYTP--------------GEVIPIFAEIDNCTTRAVIP-KAAIIQSQAFVARGTMKQKK 250

  Fly   234 VECIAVATKETGSVQK-KTERSFAHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKNLIL 297
               ..|||....:|.. |.|......|.:|. ..|:..|.. :|.:.|.|:|...:.| ..||:|
Frog   251 ---SVVATLAGDAVPAGKRETWHGRALKIPP-LGPSILQCR-IIRVEYTLKVCVEIPG-SSNLVL 309

  Fly   298 NLPFKVYSQDP----SNRQSS-----------LRPPPPPRPNDGPPGPELGSGNLFEPALPVYPS 347
            .||. |....|    .:|.||           ||...|.:|.   |.|:..|....|.|
Frog   310 ELPL-VIGTIPLHPFGSRTSSVGSQYSVNLEWLRMTVPEQPE---PPPDYSSVVSEEEA------ 364

  Fly   348 LDSSIGSPSHSS 359
             :.::..|.|||
Frog   365 -EHNLSPPHHSS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	45/158 (28%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	32/127 (25%)
arrdc2	XP_012821263.1	Arrestin_N	36..171	CDD:334019	43/153 (28%)
arrdc2	XP_012821263.1	Arrestin_C	195..320	CDD:214976	36/146 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920