Protein Alignment Leash and Arrdc4

DIOPT Version :9

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001036057.1
• Gene: Arrdc4 / 66412
• MGIID: 1913662
• Length: 415
• Species: Mus musculus
• Alignment Length: 487
• Identity: 102/487 - (20%)
• Similarity: 166/487 - (34%)
• Gaps: 132/487 - (27%)

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLF----- 70
            |.:...|.:|:.:.|.:.:...:...:|.::::..|:....|        ..:..:|...
Mouse    23 DESKGCYSSGETVAGHVLLEAAEPVALRGLRLEAQGRATSAW--------GPSAGARVCIGGGSP 79

  Fly    71 YTSKEVYEHSETPLPDFE-PRG---LELSAGEHTFIFEVALGRQLPS-----SFKGSYGAIKYKM 126
            ..|.|| |:....|...| |.|   ..|..|:|.|.|..    ||||     ||.|.||:|:|.:
Mouse    80 AASSEV-EYLNLRLSLLEAPAGEGVTLLQPGKHEFPFRF----QLPSEPLATSFTGKYGSIQYCV 139

  Fly   127 RVLIQRPWTFDERHTIPFTVVKNMPLQ--PMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDF 189
            |.:::||...|:.......||.::.:.  |:...:..:.||.|  ...||.:.|::|...:....
Mouse   140 RAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMV--GCWLFTSGPVSLSVKIERKG 202

  Fly   190 AVRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERS 254
            ...||.:.|.|.:.|.|:..|.. :..:.|..||.:....:..:.....|.....||  ..|:..
Mouse   203 YCNGEAIPIYAEIENCSSRLVVP-KAAIFQTQTYLASGKTKTVRHMVANVRGNHIGS--GSTDTW 264

  Fly   255 FAHELLLPDGAQPTDEQMSG--VITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPSNRQSSLRP 317
            ....|.:|    |....:..  :|.:.|.|.|...:.| .|.|:|.||..:.:.
Mouse   265 NGKMLKIP----PVTPSILDCCIIRVDYSLAVYIHIPG-AKRLMLELPLVIGTI----------- 313

  Fly   318 PPPPRPNDGPPGPELGSGNLFEPALPVYPSLDSSIGSPSHSSQFSECSSINSITSDSSAATLSPA 382
                        |..|.|.           .:||:     :||||
Mouse   314 ------------PYSGFGR-----------RNSSV-----ASQFS-------------------- 330

  Fly   383 VGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYPPPHLPAYPPPESPQ 447
                   |||.:.:.:...|               |..|.:.:.::.:.....|:|.||.|....
Mouse   331 -------MDMCWLALALPEQ---------------PEAPPNYADVVSEEEFSRHVPPYPQPSDCD 373

  Fly   448 ----YSLLA------LTPPPAGVVAAPPTGGA 469
                ||:.|      ..|||......|..|.|
Mouse   374 GEACYSMFACIQEFRFQPPPLYSEVDPHPGDA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	38/154 (25%)
		Arrestin_C	178..305	CDD:280848	29/128 (23%)
Arrdc4	NP_001036057.1	Arrestin_N	19..166	CDD:306778	38/155 (25%)
		Arrestin_C	188..315	CDD:214976	29/157 (18%)
		PPxY motif 1. /evidence=ECO:0000305	347..350		1/2 (50%)
		PPxY motif 2. /evidence=ECO:0000305	392..395		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820