DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Leash and CG18745

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_652648.1	Gene:	CG18745 / 59141	FlyBaseID:	FBgn0042102	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	124/498 - (24%)
Similarity:	213/498 - (42%)	Gaps:	115/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSKEVYEHSE 81
            ||.|:::.|.:.:.::|...::||.:.:||..:.:|:|  |..:|.....|:  :..:|.|..|:
  Fly    17 YFGGEVLTGRVTLKLDKMKLVKAITLNITGYAETRWIE--RVTTNRRRRRRT--FCGREDYIASK 77

  Fly    82 TPLPDFEPRGLELS------AGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPWTFDERH 140
            |.|.     |..||      ||.||:.|...:..:.||||:||:|.::|...|.:.|||.||:.:
  Fly    78 TFLV-----GSNLSSQVSIEAGIHTYNFVCLIPTECPSSFEGSHGRVRYMATVTLVRPWKFDQSY 137

  Fly   141 TIPFTVVKNMPL---QPMQRSIPSSLEKQVTKTISLFGTR--PITLLALLPEDFAVRGEPLRICA 200
            |..|||:|.|.|   .|:.| :|:  ..:.:||...:..|  |:.|...:|:...|.|:.:.:..
  Fly   138 TRCFTVLKVMDLNFDSPLLR-VPA--HSETSKTYCCWPCRSDPLALQLTVPQTGFVPGQNVPLSV 199

  Fly   201 TVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKV-ECIAVATKETGSVQKKTERSFAHELLLPDG 264
            .|.|:|...||:|..:.:..|||:|..|...... |.:.|.|.:..:||:..::.|::|:.:| .
  Fly   200 LVTNDSHIPVEQLLISFVMLVTYHSKPPSMPNTTSERLVVNTFKGDAVQRNCKKLFSYEIRVP-A 263

  Fly   265 AQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPSNRQSSLRPPPPPRPNDGPPG 329
            ..||...:.|:|.|.|::.|||.::|...|.::.:|..:.|...:.     ..|..||      |
  Fly   264 TPPTCFNLCGIIQIAYQVEVEARVKGCHNNEVVTIPLTIGSVPLAQ-----HVPIQPR------G 317

  Fly   330 --PELGSGNLFEPALPVYP------SLDSSIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAG 386
              |:|....|....:...|      |:|:||..|::..
  Fly   318 FVPQLNVNELAVEEVATAPNSSSPWSVDASIPPPNYQE--------------------------- 355

  Fly   387 TGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPLMVQSYPPPHLPAY--PPPESPQYS 449
              .:.|..|:.::|.....|..           :|.::..|...:|.|.: |.:  |.|.:|
  Fly   356 --AVHMRSTAATRSDDLDDPEP-----------VPPNTLSLDGGAYKPLY-PVFDIPSPSAP--- 403

  Fly   450 LLALTPPPAGVVAAPPTGGAAAGGAPAYSQLPSTSASASFLQP 492
                          |||.         |:|  :..|..:|:.|
  Fly   404 --------------PPTD---------YTQ--NYMAERAFVNP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	47/140 (34%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	36/127 (28%)
CG18745	NP_652648.1	Arrestin_N	5..150	CDD:278754	47/141 (33%)
CG18745	NP_652648.1	Arrestin_C	174..304	CDD:280848	37/130 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900