DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Leash and ARRDC3

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_065852.1	Gene:	ARRDC3 / 57561	HGNCID:	29263	Length:	414	Species:	Homo sapiens

Alignment Length:	403	Identity:	94/403 - (23%)
Similarity:	162/403 - (40%)	Gaps:	69/403 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYTSK- 74
            ||...||.:||.:.|.:.:.|....:::::|:...|..|.:|.| .|...:|..|:::  ||.:
Human    18 DSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTE-SRNAGSNTAYTQN--YTEEV 79

  Fly    75 EVYEHSETPL-----PDFEPRGLE-LSAGEHTFIFEVALGR-QLPSSFKGSYGAIKYKMRVLIQR 132
            |.:.|.:..:     .|....|.. :.:|.|.:.|...|.: .|.:||:|.:|:::|.::..:.|
Human    80 EYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHR 144

  Fly   133 PWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVRGEPLR 197
            ||....:....|||.:::.:.......|.:..|:.|.......:.||:|.|.:.......||.::
Human   145 PWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQ 209

  Fly   198 ICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSFAHELLLP 262
            |.|.:.|.|:..|.. :..:.|...:|:...::..| :.:|....|:.| ..|||......|.:|
Human   210 IFAEIENCSSRMVVP-KAAIYQTQAFYAKGKMKEVK-QLVANLRGESLS-SGKTETWNGKLLKIP 271

  Fly   263 DGAQPTDEQM--SGVITIVYELRVEAVLRGFFKNLILNLPFKV--------------YSQDPSNR 311
                |....:  ..:|.:.|.|.|...:.|.. :|.||||..:              .|...|..
Human   272 ----PVSPSILDCSIIRVEYSLMVYVDIPGAM-DLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMN 331

  Fly   312 QSSLRPPPPPRPNDGPPG------PELGSGNL--------FEPAL----------------PVYP 346
            .:.|....|.|| :.||.      .|....||        ||.||                |:|.
Human   332 MNWLSLSLPERP-EAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYS 395

  Fly   347 SLDSSIGSPSHSS 359
            .:|.   :|..|:
Human   396 EIDP---NPDQSA 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	38/148 (26%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	33/142 (23%)
ARRDC3	NP_065852.1	Arrestin_N	22..165	CDD:334019	36/145 (25%)
		Arrestin_C	187..314	CDD:214976	33/134 (25%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/2 (100%)
		PPxY motif 2. /evidence=ECO:0000305	391..394		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820