DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and zgc:110626

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001017889.1	Gene:	zgc:110626 / 550588	ZFINID:	ZDB-GENE-050417-447	Length:	454	Species:	Danio rerio

Alignment Length:	483	Identity:	112/483 - (23%)
Similarity:	186/483 - (38%)	Gaps:	93/483 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYS-RSLFYT----- 72
            :..:.:||.|.|::.:.|.|.|:::::.|::.||....|.|  |.......|| :..||:
Zfish    18 NNTFTSGDYISGKVILEVVKDTQMQSLSVKIKGKANVCWSE--RHGKTTVLYSDKEKFYSVERFF 80

  Fly    73 ----SKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQ-LPSSFKGSYGAIKYKMRVLIQR 132
                :|...:|.....|..:|....::.|.|.:.|...|..| .||::|||.|.:.|.:...:.|
Zfish    81 VQTDTKHANDHEMLKDPSGQPYSSVVAPGRHVYPFTFQLPLQHFPSTYKGSVGKVLYTLETKLSR 145

  Fly   133 PWTFD-----ERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVR 192
            .....     |.:.:|..||.|..|...|.   .:.:||::     |.|.....:.:..|..|..
Zfish   146 SMRVSSKAKAEFNYVPCPVVTNPELMAPQY---GTKDKQMS-----FFTSGSVSMNISTEKMAYH 202

  Fly   193 -GEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGS-VQKKTERSF 255
             ||.|:..|.|.|||:.|| |.::.:.:..::::....::...:..    ||.|. ::..::::.
Zfish   203 LGEGLKFLAEVQNNSSRAV-KPKYCLYEKHSFFARGKRKLHTHDIF----KEMGEPIEPSSKKTI 262

  Fly   256 AHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGF------FKNLIL------------NLPFK 302
            ...|.:|.....:..... ::.:.|.|||...::..      |..:||            |..|.
Zfish   263 TTVLTIPPSLTVSILNCR-ILKVEYRLRVYLDVKYASDPEIKFPIVILPVQPVSGANGARNNDFG 326

  Fly   303 VYSQDPSNRQSSLRPPPPP-----RPND--GPPGPELGSGNLFEPA----LPVYPSLDSSIGSPS 356
            :::|.|.....   |.|||     :|::  ||||.....||...|.    .|.||......|.|.
Zfish   327 IWNQPPPGIAG---PNPPPTAPSAQPHNMAGPPGQFSAPGNYGPPVGQFPSPGYPGPPLGQGGPP 388

  Fly   357 HSSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMP 421
                        |.|........:||.....|....||.||: ..|:||.....|..|:..||..
Zfish   389 ------------SYTGPPLGQFGAPAFPGPPGQSAPSYYSGA-PGQFGSSVPLQSSTSAPPPYQE 440

  Fly   422 YSSSPLMVQSYPPPHLPAYPPPESPQYS 449
            |...|.:              |:.|:.|
Zfish   441 YKFYPQL--------------PDQPEKS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	39/153 (25%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	27/146 (18%)
zgc:110626	NP_001017889.1	Arrestin_N	16..157	CDD:304627	34/140 (24%)
zgc:110626	NP_001017889.1	Arrestin_C	187..309	CDD:280848	23/127 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579441
Domainoid	1	1.000	65	1.000	Domainoid score	I10015
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750