Protein Alignment Leash and zgc:110626

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001017889.1
• Gene: zgc:110626 / 550588
• ZFINID: ZDB-GENE-050417-447
• Length: 454
• Species: Danio rerio
• Alignment Length: 483
• Identity: 112/483 - (23%)
• Similarity: 186/483 - (38%)
• Gaps: 93/483 - (19%)

  Fly    14 DRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYS-RSLFYT----- 72
            :..:.:||.|.|::.:.|.|.|:::::.|::.||....|.|  |.......|| :..||:
Zfish    18 NNTFTSGDYISGKVILEVVKDTQMQSLSVKIKGKANVCWSE--RHGKTTVLYSDKEKFYSVERFF 80

  Fly    73 ----SKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQ-LPSSFKGSYGAIKYKMRVLIQR 132
                :|...:|.....|..:|....::.|.|.:.|...|..| .||::|||.|.:.|.:...:.|
Zfish    81 VQTDTKHANDHEMLKDPSGQPYSSVVAPGRHVYPFTFQLPLQHFPSTYKGSVGKVLYTLETKLSR 145

  Fly   133 PWTFD-----ERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFAVR 192
            .....     |.:.:|..||.|..|...|.   .:.:||::     |.|.....:.:..|..|..
Zfish   146 SMRVSSKAKAEFNYVPCPVVTNPELMAPQY---GTKDKQMS-----FFTSGSVSMNISTEKMAYH 202

  Fly   193 -GEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGS-VQKKTERSF 255
             ||.|:..|.|.|||:.|| |.::.:.:..::::....::...:..    ||.|. ::..::::.
Zfish   203 LGEGLKFLAEVQNNSSRAV-KPKYCLYEKHSFFARGKRKLHTHDIF----KEMGEPIEPSSKKTI 262

  Fly   256 AHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGF------FKNLIL------------NLPFK 302
            ...|.:|.....:..... ::.:.|.|||...::..      |..:||            |..|.
Zfish   263 TTVLTIPPSLTVSILNCR-ILKVEYRLRVYLDVKYASDPEIKFPIVILPVQPVSGANGARNNDFG 326

  Fly   303 VYSQDPSNRQSSLRPPPPP-----RPND--GPPGPELGSGNLFEPA----LPVYPSLDSSIGSPS 356
            :::|.|.....   |.|||     :|::  ||||.....||...|.    .|.||......|.|.
Zfish   327 IWNQPPPGIAG---PNPPPTAPSAQPHNMAGPPGQFSAPGNYGPPVGQFPSPGYPGPPLGQGGPP 388

  Fly   357 HSSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMP 421
                        |.|........:||.....|....||.||: ..|:||.....|..|:..||..
Zfish   389 ------------SYTGPPLGQFGAPAFPGPPGQSAPSYYSGA-PGQFGSSVPLQSSTSAPPPYQE 440

  Fly   422 YSSSPLMVQSYPPPHLPAYPPPESPQYS 449
            |...|.:              |:.|:.|
Zfish   441 YKFYPQL--------------PDQPEKS 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	39/153 (25%)
		Arrestin_C	191..308	CDD:214976	26/136 (19%)
zgc:110626	NP_001017889.1	Arrestin_N	16..157	CDD:451447	34/140 (24%)
		Arrestin_C	186..313	CDD:460676	26/132 (20%)
		PRK07764	<314..440	CDD:236090	37/141 (26%)