DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and CG14696

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_650035.1	Gene:	CG14696 / 41317	FlyBaseID:	FBgn0037853	Length:	457	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	120/524 - (22%)
Similarity:	202/524 - (38%)	Gaps:	113/524 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SERLRITLDSAD-RVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYS 66
            |.::....||.. .:|.||.:|.|...:...:...||:|.:.:.|.|:.:|.|...:...:.:.:
  Fly     2 SSKVNFVFDSNPLGLYQAGQLISGTAELITERPKTIRSIFITINGYGETRWQESEERVGEDGKTT 66

  Fly    67 RSLF-YTSKEVYEHSETPLPDFEPRG---LELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMR 127
            :||. :|:.|||..::.|:  :...|   |||..|::.|.|...:....|:||.|::|.||:::.
  Fly    67 KSLVTHTTTEVYYSTDQPV--YGQAGGSQLELPTGKYVFPFRATIPPNAPTSFNGAHGQIKHEVT 129

  Fly   128 VLIQRPWTFDERHTIPFTVVKNMPL-------QPMQRSIPSSLEKQVTKTISLFGT-RPITLLAL 184
            :.|.|...::......|||:....|       :|:||     ||.:.....|:||. :|:.:...
  Fly   130 LTIDRAVRYNNTFKQCFTVILPHDLNRRLEYKEPLQR-----LESKSFWWGSIFGAHKPMIMDVS 189

  Fly   185 LPEDFAVRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQ--KVECIAVATKETGSV 247
            ......|.|:.:.....:.|.|......::..:::.|:|.::.....:  ||....||.|..|.|
  Fly   190 TSYSAYVPGQKIHFHLVLDNQSDVQCMDVKVRLIKNVSYRANSSGAKEQLKVTESRVADKHCGEV 254

  Fly   248 QKKTERSFAHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFK-----NLILNLPFKVYS-- 305
            .|..:..|...|.:|. ..|:.:.....|.:.|.||..|..   ||     :|:::.|..:.:
  Fly   255 LKHNKAKFDEFLTVPP-TTPSTQSEKDPIRVSYTLRFIAKT---FKLHGGGDLVMDFPITIGTVP 315

  Fly   306 -------QDPSNRQSSLRPPPPPRPNDGPP------GPELGSGNLFEPALPVYPSLDSSIGSPSH 357
                   :.|...:|.    |....:.|.|      ..|....|.|:|..|||| .|   |.|.
  Fly   316 LLGSADDKGPGAEKSQ----PSGASHPGSPNFQEDVSDEQFESNTFKPRYPVYP-FD---GKPG- 371

  Fly   358 SSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPY 422
                         |:.|:.|...|::                     .|.|..:..::.|.:.|.
  Fly   372 -------------TNGSNGAANFPSL---------------------YPKAEEAHPATPVKFTPN 402

  Fly   423 SSSPLMVQSYPPPHLPAYPPPESPQYSLLALTPPPAGVVAAPPTGGAAAGG---APAYSQLPSTS 484
            ..||...:|  ||:....|                   ||:||.|.....|   .|.|...||..
  Fly   403 PVSPAAQKS--PPYTTNTP-------------------VASPPGGNFEVLGFSIPPDYKPTPSAP 446

  Fly   485 ASAS 488
            |::|
  Fly   447 AASS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	40/150 (27%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	28/133 (21%)
CG14696	NP_650035.1	Arrestin_N	5..155	CDD:278754	40/151 (26%)
CG14696	NP_650035.1	Arrestin_C	182..313	CDD:280848	28/134 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900