DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and CG2993

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001262348.1	Gene:	CG2993 / 40924	FlyBaseID:	FBgn0037521	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	106/470 - (22%)
Similarity:	186/470 - (39%)	Gaps:	84/470 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSL-----FYTSKE 75
            ||:||..:.|.:.::|:...:|:.|.|.|:|..|.:|:    |.....:..|::     .|.|..
  Fly    16 VYYAGQELSGVVDLSVDATKRIKGIHVTVSGYAKIRWI----KKGYPRDSERAMCRAYRSYLSSR 76

  Fly    76 VY------EHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRPW 134
            .|      .:|....|          |||:::.|.|.|...||:||.|.||.|.|::...|:|..
  Fly    77 SYVLGSCANNSSIDWP----------AGEYSYTFHVILPDNLPTSFDGKYGQIHYEIITTIERAA 131

  Fly   135 TFDERHTIPFTVVK----------NMPLQPMQRSIPSSLEKQVTKTISLF--GTRPITLLALLPE 187
            ...:...:||||::          .:||:.:.|           |....|  .|.|:|:....|.
  Fly   132 RHPKVFKLPFTVIQPLDLNADAIYRVPLEILDR-----------KRFWSFCCPTGPLTVKFSTPY 185

  Fly   188 DFAVRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTE 252
            .....|:.:.....:.|.|:..:.:....:.|.|:|.||.|....:.:...:|.|:.|:|.:.:.
  Fly   186 CGYAPGQKIHFVLYINNESSIDIIECEVKLKQEVSYESHDPQHEYRYDKHLIARKQFGNVLRWSR 250

  Fly   253 RSFAHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYS----QDPS---- 309
            :.:...|.|| ...||..:.:..|::.|.:::......|...|.|.:|..:.|    ..|.
  Fly   251 KVYRGYLDLP-SIPPTSVKPTCPISVNYSIKIIVNPTEFHWKLKLKIPLTIGSIPIMDGPEALLR 314

  Fly   310 -NRQ--------SSLRPPPPPRPNDGPPGPELGSGNLFEPALPVYPSLDSSIGSPSHSSQFSECS 365
             |||        .:|:.....|..|.....::.        :......|......|.|.|....|
  Fly   315 FNRQQQQHQVVSQNLQMSTQQRQRDRDRDRDMN--------VDRERDRDRDRDRISASVQQRRIS 371

  Fly   366 SINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSA---RTSLRSSNVPYMPYSSSPL 427
            |||:  ::::...|...:......|:| .|:.|.:....:||:   ..:||.:.:|.:..:|.
  Fly   372 SINN--NNNNHGRLVGGLLPTNSNMNM-ITNVSPTPTSSTPSSTPTTAALRPTAMPAILVTSD-- 431

  Fly   428 MVQSYPPPHLPAYPP 442
              ...||.::|..||
  Fly   432 --SDNPPDYIPMMPP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	41/156 (26%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	27/126 (21%)
CG2993	NP_001262348.1	Arrestin_N	5..150	CDD:304627	41/147 (28%)
CG2993	NP_001262348.1	Arrestin_C	173..302	CDD:280848	28/129 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900