DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Leash and CG10086

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_649736.3	Gene:	CG10086 / 40920	FlyBaseID:	FBgn0037517	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	122/480 - (25%)
Similarity:	198/480 - (41%)	Gaps:	78/480 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SERLRITLDSADR-VYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSN----N 62
            |:...||.|..:. .||.|.:|.|::.:|:||..|:|.||:|::|..:.:|.  :|::..    .
  Fly     2 SKNCMITFDQNEHGTYFTGQVITGKVIVNLNKTKKLRGIKLQISGYAQAQWR--IRRHGKAVAIQ 64

  Fly    63 NEYSRSLF-YTSKEVYEHSETPLPDFEP-RGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYK 125
            |...||.. |:.:|.|..|.|.|...|. ....:.||.:|:.|...:....||||:|:||.|:|.
  Fly    65 NPKKRSKHQYSGREDYIASTTYLMGSEQGSNFNMDAGTYTYTFACPIPSHCPSSFEGAYGHIRYL 129

  Fly   126 MRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFA 190
            .:|...:|...:..|.:.|||:|.:.|....:.:......:..:...|..|:|:.|...|.:...
  Fly   130 AKVTFLKPGASNRTHNVGFTVLKLLDLNQETKMLREPASNEAVEHFCLMHTKPVQLKVTLQQQGY 194

  Fly   191 VRGEPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQKVECIAVATKETGSVQKKTERSF 255
            |.|:.:.|.|.|.|:|::...||...:....||.:..|......|.|.:..:|.|.|....:|::
  Fly   195 VPGQFMLIHAHVRNDSSSDCRKLLIMLHLRATYTADTPSLRTTSEKIMLVKRECGPVAHNAQRTY 259

  Fly   256 AHELLLPDGAQPTDEQMSGVITIVYELRVEAVLRGFFKNLILNLPFKVYSQDPSNRQSSLRPPPP 320
            ...|.:|..| ||.|.:|.|:.:.||:||.||:.....|..|.:|..:.:...:...|
  Fly   260 TETLRIPATA-PTCEHLSKVVRVSYEVRVVAVMNWLMANPRLIIPVTIGNVPLATAVS------- 316

  Fly   321 PRPNDGPPGPELGSGNLFEPALPVYPSLDSSIGSPSHSSQFSE--CSSINSITSDSSAATLSPAV 383
                    ||:....|.|                ||.||..::  |:|..::.....||:
  Fly   317 --------GPDFLPTNAF----------------PSGSSLPADLPCTSTRAMELAQMAAS----- 352

  Fly   384 GAGTGGMDMSYTSGSQSSQYGSP-SARTSLRSSN--VPYMP---YSSSPLMV------------- 429
            |....|.:|:    .....:..| .....|.:::  ||.:|   |..:..|.
  Fly   353 GVSNSGYEMA----EDLEDFELPEDGDDELEAADDFVPDLPPPTYEQAMFMTTDIADTDANTVSE 413

  Fly   430 QSYPPPHLPAY-------PPPESPQ 447
            .|...|..|.:       |||..||
  Fly   414 ASRFTPRYPVFDVDTFQSPPPNPPQ 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	49/152 (32%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	38/126 (30%)
CG10086	NP_649736.3	Arrestin_N	5..157	CDD:278754	49/153 (32%)
CG10086	NP_649736.3	Arrestin_C	179..308	CDD:280848	39/129 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464097
Domainoid	1	1.000	65	1.000	Domainoid score	I10015
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900