Protein Alignment Leash and Arrdc1

DIOPT Version :10

• Sequence 1: NP_650037.2
• Gene: Leash / 41320
• FlyBaseID: FBgn0037856
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_006497901.1
• Gene: Arrdc1 / 215705
• MGIID: 2446136
• Length: 436
• Species: Mus musculus
• Alignment Length: 477
• Identity: 117/477 - (24%)
• Similarity: 187/477 - (39%)
• Gaps: 104/477 - (21%)

  Fly     8 ITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRSLFYT 72
            |.|.....||..|:.:.|.:.:.:......|||:  ||..|.|.    :...:|:..      :.
Mouse     9 IRLSQGRVVYGPGEPLAGTVHLRLGAPLPFRAIR--VTCMGSCG----VSTKANDGA------WV 61

  Fly    73 SKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRP-WTF 136
            .:|.|.:|...|.|   :| .|.||||.|.|:..|....|:||:|.:|.|.:::|..|..| ::.
Mouse    62 VEESYFNSSLSLAD---KG-SLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSK 122

  Fly   137 DERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISLFG-----TRPITLLALLPEDFAVRGEPL 196
            |.:.::.|.::..:.|    .|||...:..|..|...|.     |..:.|.|.......|.|:.|
Mouse   123 DHKCSLVFYILSPLNL----NSIPDIEQPNVASTTKKFSYKLVKTGNVVLTASTDLRGYVVGQVL 183

  Fly   197 RICATVINNSTTAVEKLRFTVLQYVTYYSHVPLRVQK--VECIAVATKETGSVQKKTERSFAHEL 259
            |:.|.:.|.|......:..::||.|:|      :.::  .:...:|..|...|:......:..::
Mouse   184 RLQADIENQSGKDTSPVVASLLQKVSY------KAKRWIYDVRTIAEVEGTGVKAWRRAQWQEQI 242

  Fly   260 L---LPDGAQPTDEQMSGVITIVYELRVE-------AVLRGFFKNLILNLPFKVYSQDPSNRQSS 314
            |   ||..|.|.    ..:|.|.|.|:|.       ..|..|..|:.:|             |:.
Mouse   243 LVPALPQSALPG----CSLIHIDYYLQVSMKAPEATVTLPLFVGNIAVN-------------QTP 290

  Fly   315 LRPPPPPRPNDGPPGPELGSG--NLFEPALPVYPSLDSSIGSPSHSSQFSECSSINSITSDSSAA 377
            |.|         .||.|...|  :|..|:.|.....::....|    .||:..|: |..|.|...
Mouse   291 LSP---------CPGRESSPGTLSLVVPSAPPQEEAEAVASGP----HFSDPVSL-STKSHSQQQ 341

  Fly   378 TLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLR-------SSNVPY--------MPYSSSPL 427
            .||..:|:      :|.|:.....|.||| ||.||.       .:.|||        :|.:|:.:
Mouse   342 PLSAPLGS------VSVTTTEPWVQVGSP-ARHSLHPPLCISIGATVPYFAEGSAGPVPTTSALI 399

  Fly   428 MVQSYPPPHLPAYPPPESPQYS 449
            :     ||...::..|..|.:|
Mouse   400 L-----PPEYSSWGYPYDPSFS 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:451447	39/144 (27%)
		Arrestin_C	191..308	CDD:214976	28/128 (22%)
Arrdc1	XP_006497901.1	Arrestin_N	7..139	CDD:451447	40/149 (27%)
		Arrestin_C	162..284	CDD:460676	29/131 (22%)
		PHA03247	<289..429	CDD:223021	39/154 (25%)