DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Leash and arrd-28

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_509710.2	Gene:	arrd-28 / 184759	WormBaseID:	WBGene00009000	Length:	650	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	66/328 - (20%)
Similarity:	111/328 - (33%)	Gaps:	113/328 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESERLRIT---------LDSAD-RVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKC--KWM 53
            ::.|:|.:|         |:.|| .|.|.         ||..:..::|::::.:||:.:.  .|.
Worm   326 VDIEKLSVTNVTQSEKKPLERADVEVTFI---------MNSVEPKELRSLRLILTGEVRVGGLWY 381

  Fly    54 EILRKNSNNNEYSRSLFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGS 118
            |.||..:..|....:|                        ||.|||.|.|      |||
Worm   382 EFLRFKAIANLSHETL------------------------LSPGEHNFRF------QLP------ 410

  Fly   119 YGAIKYKMRVLIQRPWTFDER-----HTIPFTVVKNMPLQPMQRSIPSSLE---KQVTKTISLFG 175
            :...:|...:|   |.|..:.     |....::.||...|..:..:...::   |:..|.
Worm   411 FADSQYDTSIL---PPTLGDEIKYMIHASTVSLPKNFFQQQCELLVDRFIDTWAKEAYKP----- 467

  Fly   176 TRPITLLALLPEDFAVRGEPLRICATVINNSTTAVEKLRFTVL-------QYV--TYYSHVPLRV 231
              |.|      |::.         ||.|:.|....::.:..::       :||  |......|||
Worm   468 --PYT------EEYG---------ATKIHLSQRCFKRGKHVIVALQGSEPRYVKGTLVQKKRLRV 515

  Fly   232 QKVECIAVATKETGSVQKKT--------ERSFAHELLLPDGAQPTDEQMS-GVITIVYELRVEAV 287
            ..|:     ..|:...|:..        .:...|.:.:|....|:.|... .|:.|.|...||..
Worm   516 PNVK-----LDESYCSQRNVRIFEENIHRKDHIHVMHIPFNIPPSIEICYWNVLQIEYHYEVEIT 575

  Fly   288 LRG 290
            |.|
Worm   576 LEG 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	35/162 (22%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	27/131 (21%)
arrd-28	NP_509710.2	Arrestin_C	153..278	CDD:214976
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100