DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Leash and arrd-18

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_503916.1	Gene:	arrd-18 / 178763	WormBaseID:	WBGene00018060	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	499	Identity:	135/499 - (27%)
Similarity:	208/499 - (41%)	Gaps:	107/499 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESERLRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNN---- 62
            ::|.|::..|..|.|:|.|..|.|.:.:...:..|.||:.:::.|.....|     ||..|
Worm     3 KTELLKVIFDQPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSW-----KNYENACKF 62

  Fly    63 NEYS-----RSLFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAI 122
            |..|     ||:.|::...|......|...|....||:|||:.:.|...|...:|.||:|.||.:
Worm    63 NGSSISIRPRSIHYSANVNYLDYTQLLWTCEDGKNELAAGEYVWPFSYTLPTSIPPSFEGKYGYV 127

  Fly   123 KYKMRVLIQRPWTFDERHTIPFTVVKNMPLQPMQRSIPSSLEKQVTKTISL--FGTRPITLLALL 185
            :|.::|.:.|||..|:...:..||...:.|..:..|: :.:..|.::.||.  |....:.:...:
Worm   128 RYTVKVEVDRPWRKDKAKKMCITVSPLLDLNVIPHSL-TQINHQASENISFCCFQGGILEMSLNI 191

  Fly   186 PEDFAVRGEPLRICATVINNSTTAVEKLRFTVLQY---------VTY-----YSHVPLRVQKVEC 236
            |:...|.||.:.:...:||:|:|:|..::..:||.         .||     :........|::.
Worm   192 PKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFTGYKSGATYNYGGDFERNEKMSDKIQR 256

  Fly   237 IAVATKETGSV-QK-----KTERSFAHELLLPDGAQPTDEQMSGVITIVY--ELRVEAVLRGFFK 293
            |...||:...| ||     |.|..|..||.:| ...||..|.|.|||:.|  ::.|:.::| ...
Worm   257 IKFDTKKVVKVCQKLEVPAKNEHKFVLELRIP-SVTPTINQFSPVITVEYILQVNVDGLVR-CES 319

  Fly   294 NLILN-------LPFKVYSQDPSNRQSSLRPPPPPRPNDGPP---GP------ELGSGNLFEPAL 342
            :::|.       ||...|.|||:      .||..|.|...||   ||      |.|:...:  .|
Worm   320 SILLGSVPIHQYLPPAYYQQDPN------LPPSKPTPIGAPPPGYGPLPTDDSEKGADAPY--PL 376

  Fly   343 PVYPSL-DSSIGSPSHSSQFSECSSINSITSDSSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSP 406
            .:||:: |..:.:|:...           |.|.:|...|         ...||    |.|.||
Worm   377 DLYPNVNDEKVPNPNEDP-----------TKDGTAVLPS---------APPSY----QESMYG-- 415

  Fly   407 SARTSL-RSSNVPYMPYSSSPLMVQSYP-----PPHLPAYPPPE 444
            .|.|.| ...|.||:|         .||     |.:.|..||||
Worm   416 KAGTVLDAKENGPYVP---------KYPVFNNLPVYNPTAPPPE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	45/154 (29%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	39/155 (25%)
arrd-18	NP_503916.1	Arrestin_N	9..158	CDD:334019	44/153 (29%)
arrd-18	NP_503916.1	Arrestin_C	183..327	CDD:214976	37/145 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920