DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Leash and arrdc1a

DIOPT Version :9

Sequence 1:	NP_650037.2	Gene:	Leash / 41320	FlyBaseID:	FBgn0037856	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_005171840.1	Gene:	arrdc1a / 100006005	ZFINID:	ZDB-GENE-030925-15	Length:	447	Species:	Danio rerio

Alignment Length:	470	Identity:	121/470 - (25%)
Similarity:	197/470 - (41%)	Gaps:	74/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ERLRITLDSADRVYFAGDIIRGEIWMNVNKRTKIRAIKVQVTGKGKCKWMEILRKNSNNNEYSRS 68
            :...||.|:...||..|:.:.|.:.:::.:..:.:||||..  :|.|.    :...||:.:
Zfish     5 QEFEITFDNNKTVYSPGESLTGTLKISIAQSIQCKAIKVNC--QGFCG----VTSKSNDTD---- 59

  Fly    69 LFYTSKEVYEHSETPLPDFEPRGLELSAGEHTFIFEVALGRQLPSSFKGSYGAIKYKMRVLIQRP 133
              :|.:|.|..|...:.|   :| .|..|||:|.|:..|....|:||.|.||.|.|::|..|..|
Zfish    60 --WTDEEQYFSSSVSIAD---KG-TLKEGEHSFPFKFLLPAAAPTSFVGPYGQIMYRVRAFIDTP 118

  Fly   134 -WTFDERHTIPFTVVKNMPLQ--PMQRSIPSSLEKQVTKTISLFGTRPITLLALLPEDFA--VRG 193
             :..|.:...||::...:.|.  |..|. |||  ..|||..|....:..|::.....|..  :.|
Zfish   119 RFAKDYKIEKPFSMTNTLNLNEVPGIRE-PSS--SSVTKNFSYMLVKNGTVVLNAKTDMRGYIAG 180

  Fly   194 EPLRICATVINNSTTAVEKLRFTVLQYVTYYSHVP---LRVQKVECIAVATKETGSVQKKTERSF 255
            :.:::.|.:.|.|......:..:::|.|||.:..|   ||       :||..|...|:...:..:
Zfish   181 QIIKVSAGIENKSDKTTGHVVASLMQKVTYNTKKPTYDLR-------SVAEVEGPGVKGGNKSEW 238

  Fly   256 AHELLLPDGAQPTDEQMSG-VITIVYELRVEAVLRGFFKNLILNLPFKVYS--QDPS--NRQSSL 315
            ..::::|  |.|......| :|.|.|.::|  .|:  :..:.|.||..:.|  .|||  :...::
Zfish   239 NQQIIVP--ALPHSSLSDGNLIQICYYIQV--YLK--YPEVALTLPICIGSVALDPSQPSHSQTV 297

  Fly   316 RPPPPPR--PNDGPPGPELGSGNLFEPALPV-----YPSLDSSIGSPSHS--SQFSECSSINSIT 371
            .|.|.||  |...|..||..:.||  |..|.     .|...|:..|||..  ..:.:..|:::..
Zfish   298 APMPAPRITPAPSPSAPESEASNL--PPRPAPKPAPKPRPRSTHASPSAPPVDLYPQLPSVSNYN 360

  Fly   372 SD---------SSAATLSPAVGAGTGGMDMSYTSGSQSSQYGSPSARTSLRSSNVPYMPYSSSPL 427
            .:         .|...:||...:...|:.......|.......||..:|.:..|  .||.|:
Zfish   361 GEMLKSPHQEPGSQGPVSPNAFSYAPGLSFRQRQSSSGPSAPPPSLSSSSQDRN--QMPSSA--- 420

  Fly   428 MVQSYPPPH-LPAYP 441
               |.||.: ..|||
Zfish   421 ---SVPPSYRSSAYP 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Leash	NP_650037.2	Arrestin_N	6..152	CDD:304627	42/146 (29%)
Leash	NP_650037.2	Arrestin_C	178..305	CDD:280848	29/132 (22%)
arrdc1a	XP_005171840.1	Arrestin_N	7..139	CDD:304627	42/147 (29%)
arrdc1a	XP_005171840.1	Arrestin_C	162..283	CDD:280848	29/133 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850