DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6621 and ttc14

DIOPT Version :9

Sequence 1:	NP_650036.2	Gene:	CG6621 / 41319	FlyBaseID:	FBgn0037855	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	XP_012818843.1	Gene:	ttc14 / 733801	XenbaseID:	XB-GENE-989065	Length:	721	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	231/906 - (25%)
Similarity:	360/906 - (39%)	Gaps:	254/906 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNFDYIGQALGYHGQPLQKIWDDERGVDDLRLMGLTQVNYGVYQE------RQKYFTFQERAKRL 59
            |..|.:.|:|..||..|            |.|:...|..:..:::      :...:..:..|:..
Frog     1 MEKDLVRQSLSQHGPSL------------LSLLKSEQHEHAGFKQLLGDLSKWPQYRKERNAENP 53

  Fly    60 KMHQFLARKATDLYDRTLVANVMEDSLL---AQGNTYMTQMAPFEFFLNVKDKRKGWAHRLSALK 121
            ::.||:||||..|:..:..:|..|.|.:   |||:  ...|.|.|.|:.|...:|.......| :
Frog    54 ELQQFIARKADLLFATSWKSNSQEKSEMQEVAQGS--YAVMPPLEQFMEVPSAQKRELFFRDA-E 115

  Fly   122 QGDIIYTQVTRLASGNRLIVKPLCTAEPKHAYLADI---------PIKAVILQDFWGPLPLDKQG 177
            :|||:..::|.:.... ..::.||...   ..|.||         |::.|..|        ...|
Frog   116 RGDIVIGRITCIREFG-FFLELLCMGS---GILRDIKDLKINALCPVRDVPSQ--------SSHG 168

  Fly   178 NPRSFVQ-NDILRCEINNISADTERLSLNMIGMFNKVPD----LKFGLCDFKELPKYYSKIHNLD 237
            :|.|:.| .|:::..:.:|....|:|:|::  ..:.:|.    :|.|:....::|:||.:...|.
Frog   169 DPLSYYQTGDLIQAAVKDIDRFHEKLTLSL--HKSALPTHQSFIKLGVISTDDMPEYYRQSLVLS 231

  Fly   238 HPSASHYEDELNKALEFENP-NYDLLFQMNGLQPNENLSLMSYL-RAGFPEEENAAELRQKQASQ 300
             .:.:.:|..|.::|.|.|| :.|:|....|:..:...||:..| |..|.:::.|..||:||:|.
Frog   232 -DNLNTFEKILRQSLAFSNPSSVDILLSKLGIDESNPPSLIRGLQRENFRDQDYAPFLRKKQSSS 295

  Fly   301 WAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHL 365
            ||.:.|..|:::||.|:.|:|....||||.||.:|||||||||||||.:||..|.:.|||.||..
Frog   296 WALKCVKHGVDYFKVGRHVDAMNEYNKALEIDDKNVEALVARGALYATKGSLNKAINDFEIALEN 360

  Fly   366 NKYHVNARKYMGETLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSLDALHRSGDGKRRI 430
            ...|.|||||:.:|||..|...|||:::..|...||..|.|.....||.::|..|      ::|:
Frog   361 CPNHRNARKYLCQTLVERGGQLEEEDKLLNAESYYSKVLTLDETFTEAEEALSKL------RQRM 419

  Fly   431 STEPSNMTGGQSSDESSSSSASDSECEDSAGKPKSNISQPFYAQHKLKQSGDEKLAVIDAHKANE 495
                      |.|.|.                               ::..|||     ..|..|
Frog   420 ----------QKSLEK-------------------------------REEQDEK-----EEKVKE 438

  Fly   496 FRLDDDETVSSVRKLLREASKHKKAKKKGK------------------KKKDKKERRRSRTKSET 542
            .::  :.:...:||||:| .|.||..|:|.                  ||:.||:|||..::|.:
Frog   439 KKI--ETSAEKLRKLLKE-EKRKKKHKQGSSSSSSSGSSSDTSSSDSHKKQKKKKRRRKLSESSS 500

  Fly   543 EDPIELLKKIDFQEALRQDNKLMNSTRSDEERKAKIKSYLKEGGKESPPPPPPMKKTAVSSRKSS 607
                            |....|.|.....:|     :.|       |||          ::..:|
Frog   501 ----------------RSKKSLSNDPSHHKE-----ECY-------SPP----------ANTSAS 527

  Fly   608 FDNVGPSTSRHAASVVGFGGAQPPPAPKFLGQKKHPEPAPKLSFQIKKRPLQMDKLGMLRLAAPA 672
            |.|       |.:.|           ||.|  |:|                  |:||..|
Frog   528 FLN-------HKSEV-----------PKML--KEH------------------DRLGHRR----- 549

  Fly   673 EPLKGGRSSSSRSRSRSRSRSRSRSRNRRLGRSTRS--SLRSRRS-GSRSRSISRSRSRRRRTYS 734
                     :|.:|.||.|.|......|..|||..|  ||.|.:: .|.||:.|.:.:.:   |.
Frog   550 ---------ASAARDRSLSSSSFEIMERIRGRSEDSIDSLSSTKTQASSSRTCSEASAGK---YK 602

  Fly   735 RSRSPSPRSYGNRFVIGRYRNRRTRRSRSFHRRRSPSPILKRRSPSPFVPRRTPSPASRYRRSRS 799
            .||..|...|               ::...||..|...:.:.|..|    |::....|::..:.|
Frog   603 SSRRDSTDLY---------------KTEERHRNSSLDHLEEGRKSS----RKSDLNLSKHVSADS 648

  Fly   800 RSRSRSRSRSPRRFQSRYMPRDRGSVNRSRYSWHNPHKRSVSRTVEPNGKDERAATPPKKG 860
            :.|     ||.......|....:|:.:|:    ....:|.|......||  ..|||....|
Frog   649 KER-----RSSGNTSGLYKTHSQGNTSRA----CTDEQRIVESDKAQNG--SAAATKCMSG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6621	NP_650036.2	TPR_11	335..408	CDD:290150	39/72 (54%)
		TPR repeat	335..365	CDD:276809	21/29 (72%)
		TPR repeat	370..404	CDD:276809	15/33 (45%)
ttc14	XP_012818843.1	S1	115..198	CDD:197648	21/94 (22%)
		TPR	284..>415	CDD:223533	63/130 (48%)
		TPR_11	307..345	CDD:315977	24/37 (65%)
		TPR repeat	330..360	CDD:276809	21/29 (72%)
		TPR repeat	365..399	CDD:276809	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I3937
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007894
OrthoInspector	1	1.000	-	-		oto104396
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5845
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960