Protein Alignment CG6621 and ttc14

DIOPT Version :10

• Sequence 1: NP_650036.2
• Gene: CG6621 / 41319
• FlyBaseID: FBgn0037855
• Length: 872
• Species: Drosophila melanogaster
• Sequence 2: NP_001014336.2
• Gene: ttc14 / 541501
• ZFINID: ZDB-GENE-050327-26
• Length: 665
• Species: Danio rerio
• Alignment Length: 743
• Identity: 191/743 - (25%)
• Similarity: 322/743 - (43%)
• Gaps: 119/743 - (16%)

  Fly     1 MNFDYIGQALGYHGQPLQKIWDDERGVDDLRLMGLTQVNYGVYQERQKYFTFQERAKRLKMHQFL 65
            |:.|.:.|::.:||:.|..:...|:. ::.....|....|....:|.|    .|::..|:  ||:
Zfish     1 MDRDLLRQSVSFHGENLLSLLKCEQN-ENPDFKHLASDLYKSLNQRDK----DEQSPVLE--QFI 58

  Fly    66 ARKATDLYDRTLVANVMEDSLLAQGNTYMTQMAPFEFFLNVK-DKRKGWAHRLSALKQGDIIYTQ 129
            ||||..|:..:...:...|....:.......|.|.|.|:.|. ::|:...:|  .:::||::..:
Zfish    59 ARKADLLFAPSWKISEPADEWQEESGEAFAVMPPLEQFMEVSFEERRELFYR--DVERGDMVIGR 121

  Fly   130 VTRLASGNRLIVKPLCTAEPKHAYLADIPIKAVILQDFWGPLPLDKQGN---PRSFVQ-NDILRC 190
            :..:.... |.|..||||......:.|:.|||:..:     ..:...||   |.|:.| .|::|.
Zfish   122 INSVRDFG-LFVTLLCTAGGLKRDIEDLEIKALCPK-----REVPSTGNHDDPLSYYQIGDLIRA 180

  Fly   191 EINNISADTER--LSLNMIGMFNKVPDLKFGLCDFKELPKYYSKIHNLDHPSASHYEDELNKALE 253
            .:.:|....|:  |||:...:...:..:|.|:.:.::||.:|::...:...|...:|..|:.:|.
Zfish   181 GVKDIDRYHEKLTLSLHSSSVSPHMEKVKLGVLNKEDLPLHYTRGEIVSSDSNETFEKLLDDSLG 245

  Fly   254 FENP-NYDLLFQMNGLQPNENLSLMSYLRA-GFPEEENAAELRQKQASQWAFRSVADGIEHFKNG 316
            ..|| |.|.|....|:...:..|||..|:: .|.||:.|..:|:||:..||.:.|..|:.|||:|
Zfish   246 LSNPLNVDFLLGKLGISDTQTPSLMRGLQSKRFKEEDFATTIRKKQSVSWALKCVKTGVGHFKSG 310

  Fly   317 QQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLKGLQDFEKALHLNKYHVNARKYMGETLV 381
            :.|:|....||||.||..|||||||||||||.:||.:|.::|||.||.....|.||:||:.:|||
Zfish   311 RHVDAMNEYNKALEIDTNNVEALVARGALYATKGSLVKAIEDFELALENCPTHRNAKKYLCQTLV 375

  Fly   382 ALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSLDALHRSGDGKRRISTEPSNMTGGQSSDES 446
            ..|...|||.::..|...|...|.|....:||.:.|:.|
Zfish   376 ERGGQVEEEEKLVTAESLYKRALVLDDTFKEAAEVLEKL-------------------------- 414

  Fly   447 SSSSASDSECEDSAGKPKSNISQPFYAQHKLKQSGDEKLAVIDAHKANEFRLDDDETVSSVRKLL 511
                                       |.::::|  .||..::|.|..|.....:.:...:||:|
Zfish   415 ---------------------------QIRIQKS--LKLKELEAAKEQEKAKTAETSAEKLRKIL 450

  Fly   512 REASKHKKAKKKGKKKKDKKERRRSRTKSETEDPIELLKKIDFQEALRQDNKLMNSTRSDEERKA 576
            :|..:.||.:|:........:  .|.:.|....|....||     :.::.:|...|:||.::.|.
Zfish   451 KEEKRMKKKRKRSTSSSTSSD--SSSSSSSDSSPSTSRKK-----SKKRKHKRRRSSRSSKKHKR 508

  Fly   577 KIKS---YLKEGGKESPPPPPPMKKTAVSSRKSSFDNVGPSTSRHAASVVGFGGAQPPPAPKFLG 638
            ::.|   ...|..::..|.|        ::..:|:.|...|.|:..:......||:        .
Zfish   509 RVSSCSDKTAEDDRDWFPAP--------ANTSASYINQNQSISKLMSESEPVWGAE--------S 557

  Fly   639 QKKHPEPAPKLSFQIKKRPLQMDKLGMLRLAAPAEPLK-----GGRSSSSRSRSRSRSRSRSRSR 698
            :.:..|...:.|.|:|.        ...|.....||||     |.|..|| |.::|....:|...
Zfish   558 RGRFEEDLERGSDQVKP--------AGFRSGVNGEPLKVNERVGNRRDSS-SSTQSEYSHKSERH 613

  Fly   699 NRRLGRSTRSSLRSRRSGSRSRSISRSR 726
            :...||:...|.|:...|.::.|.:..:
Zfish   614 SEFSGRNPSRSERAGNDGGKTNSANTKK 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6621	NP_650036.2	Spy	226..>425	CDD:443119	81/200 (41%)
		TPR repeat	335..365	CDD:276809	21/29 (72%)
		TPR repeat	370..404	CDD:276809	13/33 (39%)
ttc14	NP_001014336.2	S1	113..196	CDD:197648	22/88 (25%)
		TPR	303..>447	CDD:440225	61/198 (31%)
		TPR repeat	329..359	CDD:276809	21/29 (72%)
		TPR repeat	364..398	CDD:276809	13/33 (39%)