DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6621 and TTC14

DIOPT Version :9

Sequence 1:	NP_650036.2	Gene:	CG6621 / 41319	FlyBaseID:	FBgn0037855	Length:	872	Species:	Drosophila melanogaster
Sequence 2:	NP_597719.1	Gene:	TTC14 / 151613	HGNCID:	24697	Length:	770	Species:	Homo sapiens

Alignment Length:	931	Identity:	228/931 - (24%)
Similarity:	362/931 - (38%)	Gaps:	257/931 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNFDYIGQALGYHGQPLQKIWDDERGVDDLRLMGL----TQVNYGVYQERQKYFTFQERAKRLKM 61
            |:.|.:.|:|..||..|..:...|: .|:.....|    .:...|...:.......::|...:::
Human     1 MDRDLLRQSLNCHGSSLLSLLRSEQ-QDNPHFRSLLGSAAEPARGPPPQHPLQGRKEKRVDNIEI 64

  Fly    62 HQFLARKATDLY------DRTLVANVMEDSLLAQGNTYMTQMAPFEFFLNV--KDKRKGWAHRLS 118
            .:|:::||..|:      |....:.:.|||     ..:...|.|.|.|:.:  .|:|:.:   ..
Human    65 QKFISKKADLLFALSWKSDAPATSEINEDS-----EDHYAIMPPLEQFMEIPSMDRRELF---FR 121

  Fly   119 ALKQGDIIYTQVTR------------LASG-----NRLIVKPLCTAEPKHAYLADIPIKAVILQD 166
            .:::|||:..:::.            |.||     ..|.:..||.       |.|:|..:
Human   122 DIERGDIVIGRISSIREFGFFMVLICLGSGIMRDIAHLEITALCP-------LRDVPSHS----- 174

  Fly   167 FWGPLPLDKQGNPRSFVQ-NDILRCEINNISADTERLSLNMIGMFNKVP----DLKFGLCDFKEL 226
                    ..|:|.|:.| .||:|..|.:|....|:|::::..  :.:|    .:|.|:...:||
Human   175 --------NHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYS--SSLPPHLSGIKLGVISSEEL 229

  Fly   227 PKYYSKIHNLDHPSASHYEDELNKALEFENPN-YDLLFQMNGLQPNENLSLMSYLRA-GFPEEEN 289
            |.||.:...|:..|...||:.:..:|.|.||. .:.|.:..|:..:...|||..|:: .|.|::.
Human   230 PLYYRRSVELNSNSLESYENVMQSSLGFVNPGVVEFLLEKLGIDESNPPSLMRGLQSKNFSEDDF 294

  Fly   290 AAELRQKQASQWAFRSVADGIEHFKNGQQVEAFQCLNKALNIDPRNVEALVARGALYANRGSFLK 354
            |:.||:||::.||.:.|..|:::||.|:.|:|....||||.||.:|||||||||||||.:||..|
Human   295 ASALRKKQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNK 359

  Fly   355 GLQDFEKALHLNKYHVNARKYMGETLVALGRSYEEENRIAEAVKAYSDCLNLLPLHEEARQSLDA 419
            .::|||.||.....|.|||||:.:|||..|...|||.:...|...|...|.|....::|..:|..
Human   360 AIEDFELALENCPTHRNARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQK 424

  Fly   420 LHRSGDGKRRISTEPSNMTGGQSSDESSSSSASDSECEDSAGKPKSNISQPFYAQHKLKQSGDEK 484
            ||:.                .|.|.|.....|...|      |.|:.         |::.|. ||
Human   425 LHKY----------------MQKSLELREKQAEKEE------KQKTK---------KIETSA-EK 457

  Fly   485 LAVIDAHKANEFRLDDDETVSSVRKLLREASKHKKAKKKGKKKKD-------------------K 530
            |                      ||||:|..:.||.::|......                   |
Human   458 L----------------------RKLLKEEKRLKKKRRKSTSSSSVSSADESVSSSSSSSSSGHK 500

  Fly   531 KERRRSRTKSETEDPIELLKKIDFQEALRQDNKLMNSTRSDEERKAKIKSYLKEGGKESPPPPPP 595
            :.::..|.:||:            ..:.|:.:...:|.:.|:.||           .|..|.|
Human   501 RHKKHKRNRSES------------SRSSRRHSSRASSNQIDQNRK-----------DECYPVP-- 540

  Fly   596 MKKTAVSSRKSSFDNVGPSTSRHAASVVGFGGAQPPPAPKFLGQKKHPEPAPKLSF---QIKKR- 656
                  ::..:||.|       |...|           .|.||::      .:|.:   |||::
Human   541 ------ANTSASFLN-------HKQEV-----------EKLLGKQ------DRLQYEKTQIKEKD 575

  Fly   657 --PLQMDKLGMLRLAAPAEPLKGGRSSSSRSRSRSRSRSRSRSRNRRLGRSTRSSLRSRRSGSRS 719
              ||....|.:     |.:  .||||...|....|.......|:       |....:|.|..|
Human   576 RCPLSSSSLEI-----PDD--FGGRSEDPRDFYNSYKTQAGSSK-------TEKPYKSERHFS-- 624

  Fly   720 RSISRSRSRRRRTYSRSRSPSPRSYGNRFVIGRYRNRRTRRSRSFHRRR-SPSPILKRRSPSPFV 783
                   |||..:.|..|:...:.||.|      |..:....|..|.|| .|..:
Human   625 -------SRRNSSDSFCRNSEDKIYGYR------RFEKDIEGRKEHYRRWEPGSV---------- 666

  Fly   784 PRRTPSPASRYRRSRSRSRSRSRSRSPRRFQSRYMPRDRGSVNRSRYSWHNPHKRSVSRTVEPNG 848
             |.:.||||.....:|..:.:..:.|..|..||:..|.|.:.|:..|...:.:           |
Human   667 -RHSTSPASSEYSWKSVEKYKKYAHSGSRDFSRHEQRYRLNTNQGEYEREDNY-----------G 719

  Fly   849 KDERAATPPKKGVADDRSGRE 869
            :|.:...|.:    |..|.:|
Human   720 EDIKTEVPEE----DALSSKE 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6621	NP_650036.2	TPR_11	335..408	CDD:290150	38/72 (53%)
		TPR repeat	335..365	CDD:276809	21/29 (72%)
		TPR repeat	370..404	CDD:276809	14/33 (42%)
TTC14	NP_597719.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..56		1/19 (5%)
		S1	124..207	CDD:197648	23/102 (23%)
		TPR 1	210..243		9/32 (28%)
		TPR	290..>437	CDD:223533	66/162 (41%)
		TPR 2	307..340		14/32 (44%)
		TPR repeat	307..335	CDD:276809	11/27 (41%)
		TPR repeat	340..370	CDD:276809	21/29 (72%)
		TPR 3	342..374		19/31 (61%)
		TPR repeat	375..410	CDD:276809	14/34 (41%)
		TPR 4	382..415		11/32 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..458		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..550		19/123 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..635		22/88 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..747		14/62 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157310
Domainoid	1	1.000	74	1.000	Domainoid score	I9187
eggNOG	1	0.900	-	-		E1_28H66
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I4073
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007894
OrthoInspector	1	1.000	-	-		oto90596
orthoMCL	1	0.900	-	-		OOG6_105404
Panther	1	1.100	-	-	LDO	PTHR23184
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5845
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.750