DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14696 and CG18745

DIOPT Version :9

Sequence 1:	NP_650035.1	Gene:	CG14696 / 41317	FlyBaseID:	FBgn0037853	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_652648.1	Gene:	CG18745 / 59141	FlyBaseID:	FBgn0042102	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	112/435 - (25%)
Similarity:	197/435 - (45%)	Gaps:	53/435 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FDSNPLGLYQAGQLISGTAELITERPKTIRSIFITINGYGETRWQESEERVGEDGKTTKSLVTHT 73
            ||:||.|.|..|::::|...|..::.|.:::|.:.|.||.||||   .|||..:.:..:.  |..
  Fly     9 FDNNPHGTYFGGEVLTGRVTLKLDKMKLVKAITLNITGYAETRW---IERVTTNRRRRRR--TFC 68

  Fly    74 TTEVYYSTDQPVYGQAGGSQLELPTGKYVFPFRATIPPNAPTSFNGAHGQIKHEVTLTIDRAVRY 138
            ..|.|.::...:.|....||:.:..|.:.:.|...||...|:||.|:||::::..|:|:.|..::
  Fly    69 GREDYIASKTFLVGSNLSSQVSIEAGIHTYNFVCLIPTECPSSFEGSHGRVRYMATVTLVRPWKF 133

  Fly   139 NNTFKQCFTVILPHDLNRRLEYKEPLQRL-----ESKSF-WWGSIFGAHKPMIMDVSTSYSAYVP 197
            :.::.:||||:...|||    :..||.|:     .||:: .|..   ...|:.:.::...:.:||
  Fly   134 DQSYTRCFTVLKVMDLN----FDSPLLRVPAHSETSKTYCCWPC---RSDPLALQLTVPQTGFVP 191

  Fly   198 GQKIHFHLVLDNQSDVQCMDVKVRLIKNVSYRANSSGAKEQLKVTESRVADKHCGEVLKHN-KAK 261
            ||.:...:::.|.|.:....:.:..:..|:|.:.......  ..:|..|.:...|:.::.| |..
  Fly   192 GQNVPLSVLVTNDSHIPVEQLLISFVMLVTYHSKPPSMPN--TTSERLVVNTFKGDAVQRNCKKL 254

  Fly   262 FDEFLTVPPTTPSTQSEKDPIRVSYTLRFIAKTFKLHGGGDLVMDFPITIGTVPLLGSADDKGPG 326
            |...:.||.|.|:..:....|:::|.:...|:....|  .:.|:..|:|||:|||......:..|
  Fly   255 FSYEIRVPATPPTCFNLCGIIQIAYQVEVEARVKGCH--NNEVVTIPLTIGSVPLAQHVPIQPRG 317

  Fly   327 ------------AEKSQPSGASHPGS-------PNFQEDV---SDEQFESNTFKPRYPVYPFDGK 369
                        .|.:....:|.|.|       ||:||.|   |.....|:......||     .
  Fly   318 FVPQLNVNELAVEEVATAPNSSSPWSVDASIPPPNYQEAVHMRSTAATRSDDLDDPEPV-----P 377

  Fly   370 PGTNGSNGAANFPSLYPKAEEAHPAT--PVKFTPNPVSPAAQKSP 412
            |.|...:|.|..| |||..:...|:.  |..:|.|.::..|..:|
  Fly   378 PNTLSLDGGAYKP-LYPVFDIPSPSAPPPTDYTQNYMAERAFVNP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14696	NP_650035.1	Arrestin_N	5..155	CDD:278754	45/145 (31%)
CG14696	NP_650035.1	Arrestin_C	182..313	CDD:280848	27/131 (21%)
CG18745	NP_652648.1	Arrestin_N	5..150	CDD:278754	45/145 (31%)
CG18745	NP_652648.1	Arrestin_C	174..304	CDD:280848	27/133 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464058
Domainoid	1	1.000	94	1.000	Domainoid score	I7396
eggNOG	1	0.900	-	-		E1_KOG3780
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	43	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110793at6960
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	1	1.000	-	-		otm24709
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
	10	9.900