Protein Alignment CG14696 and ARRDC2

DIOPT Version :10

• Sequence 1: NP_650035.1
• Gene: CG14696 / 41317
• FlyBaseID: FBgn0037853
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_056498.1
• Gene: ARRDC2 / 27106
• HGNCID: 25225
• Length: 407
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 95/424 - (22%)
• Similarity: 164/424 - (38%)
• Gaps: 85/424 - (20%)

  Fly    16 LYQAGQLISGTAELITERPKTIRSIFITINGYGETRWQESEERVGEDGKTTKS------LVTHTT 74
            ::..||.::|...|.......:.::.:...|.....|.||.. .|.....|:|      :|:|..
Human    23 VFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRS-AGSSTAYTQSYSERVEVVSHRA 86

  Fly    75 TEVYYSTDQPVYGQAGGSQLELPTGKYVFPFRATIPPNAPTSFNGAHGQIKHEVTLTIDRAVRYN 139
            |.:...|         |....||.|::.|.|...:||...|||.|.||.:::.:..|:.|.....
Human    87 TLLAPDT---------GETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPA 142

  Fly   140 NTFKQCFTVILPHDLNR------RLEYKEPLQRLESKSFWWGSIFGAHKPMI-MDVSTSYSAYVP 197
            ...::.||||.|.|:|.      :...:|.:.|     .|:     .::.:: :........|.|
Human   143 RRARKVFTVIEPVDINTPALLAPQAGAREKVAR-----SWY-----CNRGLVSLSAKIDRKGYTP 197

  Fly   198 GQKIHFHLVLDNQSDVQCMDVKVRLIKNVSYRANSSGAKEQLKVTESRVADKHCG---EVLKHNK 259
            |:.|.....:||.|....:. :..:::..::.|.  ||::|.:...:.:|.:..|   ..|...:
Human   198 GEVIPVFAEIDNGSTRPVLP-RAAVVQTQTFMAR--GARKQKRAVVASLAGEPVGPGQRALWQGR 259

  Fly   260 AKFDEFLTVPPTTPSTQSEKDPIRVSYTLRFIAKTFKLHGGGDLVMDFPITIGTVPL--LGSAD- 321
            |     |.:||..||....: .:.|.|.|:...   .:.|...|:::.|:.|||:||  .||..
Human   260 A-----LRIPPVGPSILHCR-VLHVDYALKVCV---DIPGTSKLLLELPLVIGTIPLHPFGSRSS 315

  Fly   322 ----------DKGPGAEKSQPSGASHPGSPNFQEDVSDEQFESNTFKPRYPVYPFDGKPGTNGSN 376
                      |...||...:|.     ..|.:.|.|:|.: |:...:..:|: |.|......|..
Human   316 SVGSHASFLLDWRLGALPERPE-----APPEYSEVVADTE-EAALGQSPFPL-PQDPDMSLEGPF 373

  Fly   377 GA--ANF----PSLYPKAEEAHPATPVKFTPNPV 404
            .|  ..|    |.||.:.:           |||:
Human   374 FAYIQEFRYRPPPLYSEED-----------PNPL 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14696	NP_650035.1	Arrestin_N	5..155	CDD:425619	37/144 (26%)
		Arrestin_C	182..316	CDD:460676	29/137 (21%)
		PHA03247	<313..450	CDD:223021	26/111 (23%)
ARRDC2	NP_056498.1	Arrestin_N	9..158	CDD:425619	37/144 (26%)
		Arrestin_C	181..307	CDD:214976	29/137 (21%)