DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14696 and arrd-18

DIOPT Version :9

Sequence 1:	NP_650035.1	Gene:	CG14696 / 41317	FlyBaseID:	FBgn0037853	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_503916.1	Gene:	arrd-18 / 178763	WormBaseID:	WBGene00018060	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	121/494 - (24%)
Similarity:	197/494 - (39%)	Gaps:	109/494 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VFDSNPLGLYQAGQLISGTAELITERPKTIRSIFITINGYGETRWQESEERVGEDGKTTKSLVTH 72
            :|| .|..::..||.|||...|.|:.....|::.|.|.|...|.|:..|.....:|    |.::.
Worm    10 IFD-QPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENACKFNG----SSISI 69

  Fly    73 TTTEVYYSTD-------QPVYGQAGGSQLELPTGKYVFPFRATIPPNAPTSFNGAHGQIKHEVTL 130
            ....::||.:       |.::....|.. ||..|:||:||..|:|.:.|.||.|.:|.:::.|.:
Worm    70 RPRSIHYSANVNYLDYTQLLWTCEDGKN-ELAAGEYVWPFSYTLPTSIPPSFEGKYGYVRYTVKV 133

  Fly   131 TIDRAVRYNNTFKQCFTV-------ILPHDLNRRLEYKEPLQRLESKSF--WWGSIFGAHKPMIM 186
            .:||..|.:...|.|.||       ::||.|. ::.:    |..|:.||  :.|.|      :.|
Worm   134 EVDRPWRKDKAKKMCITVSPLLDLNVIPHSLT-QINH----QASENISFCCFQGGI------LEM 187

  Fly   187 DVSTSYSAYVPGQKIHFHLVLDNQSDVQCMDVKVRLIKNVSYRANSSGAK--------------- 236
            .::...:.:|||:.:..::.|.|.|.....::|.::::...:....|||.
Worm   188 SLNIPKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFTGYKSGATYNYGGDFERNEKMSD 252

  Fly   237 --EQLKVTESRVADKHCG--EVLKHNKAKFDEFLTVPPTTPSTQSEKDPIRVSYTLRFIAKTFKL 297
              :::|....:|. |.|.  ||...|:.||...|.:|..||:.......|.|.|.|       ::
Worm   253 KIQRIKFDTKKVV-KVCQKLEVPAKNEHKFVLELRIPSVTPTINQFSPVITVEYIL-------QV 309

  Fly   298 HGGGDLVMDFPITIGTVPL---LGSA---DDKGPGAEKSQPSGASHPGSPNFQEDVSDEQFESNT 356
            :..|.:..:..|.:|:||:   |..|   .|......|..|.||..||......|.|::..::
Worm   310 NVDGLVRCESSILLGSVPIHQYLPPAYYQQDPNLPPSKPTPIGAPPPGYGPLPTDDSEKGADA-- 372

  Fly   357 FKPRYPVYPFDGKPGTNG-----------SNGAANFPSLYPKAEEA---HPATPVKFTPNPVSPA 407
                  .||.|..|..|.           .:|.|..||..|..:|:   ...|.:.
Worm   373 ------PYPLDLYPNVNDEKVPNPNEDPTKDGTAVLPSAPPSYQESMYGKAGTVLD--------- 422

  Fly   408 AQKSPPYTTNTPVASPPGGNFEVLGFSIPPDYKPTPSAP 446
            |:::.||....||            |:..|.|.||...|
Worm   423 AKENGPYVPKYPV------------FNNLPVYNPTAPPP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14696	NP_650035.1	Arrestin_N	5..155	CDD:278754	47/160 (29%)
CG14696	NP_650035.1	Arrestin_C	182..313	CDD:280848	30/149 (20%)
arrd-18	NP_503916.1	Arrestin_N	9..158	CDD:334019	45/153 (29%)
arrd-18	NP_503916.1	Arrestin_C	183..327	CDD:214976	32/157 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46400
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930