DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14696 and Arrdc3

DIOPT Version :9

Sequence 1:	NP_650035.1	Gene:	CG14696 / 41317	FlyBaseID:	FBgn0037853	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001036056.1	Gene:	Arrdc3 / 105171	MGIID:	2145242	Length:	414	Species:	Mus musculus

Alignment Length:	372	Identity:	93/372 - (25%)
Similarity:	145/372 - (38%)	Gaps:	54/372 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DSNPLGLYQAGQLISGTAELITERPKTIRSIFITINGYGETRWQESEERVGEDGKTTKSLVTHTT 74
            ||| :.:|.:|..:||...|.......::|:.|...|:.:.||.||...    |..|.....:|.
Mouse    18 DSN-VPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNA----GSNTAYTQNYTE 77

  Fly    75 TEVYYSTDQPVYG--------QAGGSQLELPTGKYVFPFRATIPPNAPTSFNGAHGQIKHEVTLT 131
            ...|::....:.|        :.|...:.....:|.|.|.....|.| |||.|.||.:::.|...
Mouse    78 EVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLA-TSFEGRHGSVRYWVKAE 141

  Fly   132 IDRAVRYNNTFKQCFTVILPHDLNRRLEYKEPLQRLESKSFWWGSIFGAHKPMIMDVSTSYSAYV 196
            :.|........|:.|||....|:|............|.....|   |....|:.:........|.
Mouse   142 LHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCW---FCTSGPISLSAKIERKGYT 203

  Fly   197 PGQKIHFHLVLDNQSDVQCMDVKVRLI--KNVSYRANSSGAKEQLKVTESRVADKHCGEVLKHNK 259
            ||:.|.....::|.|.        |::  |...|:..:..||.::|..:..||:.. ||.|...|
Mouse   204 PGESIQIFAEIENCSS--------RMVVPKAAIYQTQAFYAKGKMKEVKQLVANLR-GESLSSGK 259

  Fly   260 AKF--DEFLTVPPTTPSTQSEKDPIRVSYTLRFIAKTFKLHGGGDLVMDFPITIGTVPL--LGSA 320
            .:.  .:.|.:||.:||. .:...|||.|:|....   .:.|..||::..|:.|||:||  .||.
Mouse   260 TETWNGKLLKIPPVSPSI-LDCSIIRVEYSLMVYV---DIPGAMDLLLSLPLVIGTIPLHPFGSR 320

  Fly   321 DDKGPGAEKSQ------------PSGASHPGSPNFQEDVSDEQFESN 355
                ..:..||            |.....|  |::.|.|::||..:|
Mouse   321 ----TSSVSSQCSMSMNWLALALPERPEAP--PSYAEVVTEEQRRNN 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14696	NP_650035.1	Arrestin_N	5..155	CDD:278754	39/152 (26%)
CG14696	NP_650035.1	Arrestin_C	182..313	CDD:280848	34/134 (25%)
Arrdc3	NP_001036056.1	Arrestin_N	22..165	CDD:278754	36/147 (24%)
		Arrestin_C	187..314	CDD:214976	36/139 (26%)
		PPxY motif 1. /evidence=ECO:0000305	346..349		2/4 (50%)
		PPxY motif 2. /evidence=ECO:0000305	391..394
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3780
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311636at33208
OrthoFinder	1	1.000	-	-		FOG0000089
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X122
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820