DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tpc1 and Slc25a42

DIOPT Version :9

Sequence 1:	NP_650034.1	Gene:	Tpc1 / 41316	FlyBaseID:	FBgn0037852	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	XP_006253013.1	Gene:	Slc25a42 / 689414	RGDID:	1592346	Length:	329	Species:	Rattus norvegicus

Alignment Length:	229	Identity:	63/229 - (27%)
Similarity:	97/229 - (42%)	Gaps:	43/229 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVTTGSTSEATTTTTPVPRRKHSTREQLHQMLAGGLSAAITRSTCQPLDVLKIRFQLQVEPLGKN 66
            :|..|..:||........:|.|  |:.|..:|:|.|:.|:.::...|||..||.||
  Rat    54 SVRLGEDAEAVLAGAVSTKRDH--RQVLSSLLSGALAGALAKTAVAPLDRTKIIFQ--------- 107

  Fly    67 AAKEGPGALTSKYTSIGQAVKTI---YREEGMLAFWKGHNPAQVLSIMYGICQFWTYEQLSLMAK 128
                    ::||..|..:|.:.:   |..||.|:.|:|::...|..|.|...||..:|:
  Rat   108 --------VSSKRFSAKEAFRLLYFTYLNEGFLSLWRGNSATMVRVIPYAAIQFSAHEE------ 158

  Fly   129 QTSYLADHQHLSNF-----------LCGAAAGGAAVIISTPLDVIRTRLIAQDTSKGYRNATRAV 182
               |.....|...|           |.||.||..|..::.|||::|.|: |....:.|.|.....
  Rat   159 ---YKRILGHYYGFRGEALPPWPRLLAGALAGTTAASLTYPLDLVRARM-AVTPKEMYSNIFHVF 219

  Fly   183 SAIVRQEGPRGMYRGLSSALLQITPLMGTNFMAY 216
            ..|.|:||.:.:|.|.:..:|.:.|..|.:|..|
  Rat   220 IRISREEGLKTLYFGFTPTVLGVIPYAGLSFFTY 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tpc1	NP_650034.1	Mito_carr	29..123	CDD:278578	28/96 (29%)
		PTZ00169	33..329	CDD:240302	55/198 (28%)
		Mito_carr	153..222	CDD:278578	19/64 (30%)
		Mito_carr	233..328	CDD:278578
Slc25a42	XP_006253013.1	Mito_carr	74..167	CDD:278578	32/120 (27%)
Slc25a42	XP_006253013.1	Mito_carr	<192..259	CDD:278578	19/63 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0752
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900