Protein Alignment Tpc1 and slc25a25

DIOPT Version :10

• Sequence 1: NP_650034.1
• Gene: Tpc1 / 41316
• FlyBaseID: FBgn0037852
• Length: 332
• Species: Drosophila melanogaster
• Sequence 2: XP_017951721.1
• Gene: slc25a25 / 496462
• XenbaseID: XB-GENE-5933194
• Length: 525
• Species: Xenopus tropicalis
• Alignment Length: 302
• Identity: 76/302 - (25%)
• Similarity: 135/302 - (44%)
• Gaps: 35/302 - (11%)

  Fly    32 MLAGGLSAAITRSTCQPLDVLKIRFQLQVEPLGKNAAKEGPGALTSKYTSIGQAVKTIYREEGML 96
            ::|||.:.|::|:...|||.||:..|:       :|::....::...:|.       :.||.|:.
 Frog   246 LVAGGGAGAVSRTCTAPLDRLKVLMQV-------HASRSNNMSMLGGFTQ-------MIREGGIR 296

  Fly    97 AFWKGHNPAQVLSIM-YGICQFWTYEQLS-LMAKQTSYLADHQHLSNFLCGAAAGGAAVIISTPL 159
            :.|:| |...|:.|. ....:|..|||:. ::......|..|:.|   :.|:.||..|.....|:
 Frog   297 SLWRG-NGINVIKIAPESAIKFMAYEQMKRIIGSDQETLGIHERL---VAGSLAGVIAQSSIYPM 357

  Fly   160 DVIRTRLIAQDTSKGYRNATRAVSAIVRQEGPRGMYRGLSSALLQITPLMGTNFMAYRLFSDWAC 224
            :|::||:..:.|.: |:........|:.:||....|:|....:|.|.|..|.:...|....:
 Frog   358 EVLKTRMALRKTGQ-YQGMLDCGKKILLKEGVSAFYKGYVPNMLGIIPYAGIDLAVYETLKN--- 418

  Fly   225 AFLE--VSDRSQLPTWTLLGLGASSGMLSKTIVYPFDLIKKRLQIQ-GFESNRQTFGQTLQCHGV 286
            |:|:  .:..:....:.||..|..|....:...||..|::.|:|.: ..|...|.....|..|
 Frog   419 AWLQRYATSSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAEASVEGAPQMTMSKLFKH-- 481

  Fly   287 WDCLRLTVRQEGVRGLYKGVAPTLLKSSMTTALYFSIYDKLK 328
                  .|:.||..|||:|:||..:|.....::.:.:|:.||
 Frog   482 ------IVKTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tpc1	NP_650034.1	Mito_carr	29..123	CDD:395101	24/91 (26%)
		Mito_carr	153..222	CDD:395101	16/68 (24%)
		Mito_carr	233..328	CDD:395101	24/95 (25%)
slc25a25	XP_017951721.1	FRQ1	55..199	CDD:444056
		PTZ00169	247..501	CDD:240302	72/283 (25%)