Protein Alignment Tpc1 and SLC25A25

DIOPT Version :10

• Sequence 1: NP_650034.1
• Gene: Tpc1 / 41316
• FlyBaseID: FBgn0037852
• Length: 332
• Species: Drosophila melanogaster
• Sequence 2: NP_001317917.1
• Gene: SLC25A25 / 114789
• HGNCID: 20663
• Length: 515
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 78/302 - (25%)
• Similarity: 133/302 - (44%)
• Gaps: 35/302 - (11%)

  Fly    32 MLAGGLSAAITRSTCQPLDVLKIRFQLQVEPLGKNAAKEGPGALTSKYTSIGQAVKTIYREEGML 96
            ::|||.:.|::|:...|||.||:..|:       :|::.....:...:|.       :.||.|..
Human   236 LVAGGGAGAVSRTCTAPLDRLKVLMQV-------HASRSNNMGIVGGFTQ-------MIREGGAR 286

  Fly    97 AFWKGHNPAQVLSIM-YGICQFWTYEQLS-LMAKQTSYLADHQHLSNFLCGAAAGGAAVIISTPL 159
            :.|:| |...||.|. ....:|..|||:. |:......|..|:.|   :.|:.||..|.....|:
Human   287 SLWRG-NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERL---VAGSLAGAIAQSSIYPM 347

  Fly   160 DVIRTRLIAQDTSKGYRNATRAVSAIVRQEGPRGMYRGLSSALLQITPLMGTNFMAYRLFSDWAC 224
            :|::||:..:.|.: |.........|:.:||....|:|....:|.|.|..|.:...|....:
Human   348 EVLKTRMALRKTGQ-YSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKN--- 408

  Fly   225 AFLE--VSDRSQLPTWTLLGLGASSGMLSKTIVYPFDLIKKRLQIQ-GFESNRQTFGQTLQCHGV 286
            |:|:  ..:.:....:.||..|..|....:...||..|::.|:|.| ..|...:....:|..|
Human   409 AWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKH-- 471

  Fly   287 WDCLRLTVRQEGVRGLYKGVAPTLLKSSMTTALYFSIYDKLK 328
                  .:|.||..|||:|:||..:|.....::.:.:|:.||
Human   472 ------ILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLK 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tpc1	NP_650034.1	Mito_carr	29..123	CDD:395101	25/91 (27%)
		Mito_carr	153..222	CDD:395101	16/68 (24%)
		Mito_carr	233..328	CDD:395101	24/95 (25%)
SLC25A25	NP_001317917.1	FRQ1	49..189	CDD:444056
		PTZ00169	237..491	CDD:240302	74/283 (26%)