DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and Pdia2

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_001074539.1	Gene:	Pdia2 / 69191	MGIID:	1916441	Length:	527	Species:	Mus musculus

Alignment Length:	206	Identity:	41/206 - (19%)
Similarity:	75/206 - (36%)	Gaps:	52/206 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PKVVAFHFVKNRH-----GDTLDKWISLLD---ELAQEYAGRILFGLRDI----SNI-------G 85
            ||:.|...:  .|     ..||.:...||.   |.|..:.|::||.:.|:    |::       .
Mouse   271 PKIFAAKIL--NHLLLFVNQTLAQHRELLTDFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKA 333

  Fly    86 EFNPNLNPDDFGSYRKGLPPRIYGKDCEGRVYDMHKLVNAKYLREFCDQLLADQLFRAVV----- 145
            |..|.|...:..:.:|..|..:..             :.|..:..||..:|..::...::
Mouse   334 EEAPTLRLINVETTKKYAPTGVIA-------------ITAASVAAFCQAVLHGEIKHYLLSQEIP 385

  Fly   146 ----LGATASLDSKPMNYFELREESSSDMLVMLYDPACYYW----PIQKRMLRKLIRLLASEDLP 202
                .|...:|.||  |:.::..:.:.::.|..|.|.|.:.    |..:.:..|   ....||:.
Mouse   386 PDWDQGPVKTLVSK--NFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEK---YKDREDIV 445

  Fly   203 IVIVDKANNYL 213
            |..:|...|.|
Mouse   446 IAELDATANEL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	23/112 (21%)
Pdia2	NP_001074539.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..41
		ER_PDI_fam	45..506	CDD:273457	41/206 (20%)
		PDI_a_family	48..150	CDD:239259
		PDI_b_family	158..257	CDD:239279
		PDI_b'_family	262..371	CDD:239280	23/114 (20%)
		PDI_a_PDI_a'_C	392..494	CDD:239293	16/70 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..527
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	524..527
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000