DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14695 and pdia4

DIOPT Version :9

Sequence 1:	NP_650032.1	Gene:	CG14695 / 41314	FlyBaseID:	FBgn0037850	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_956073.2	Gene:	pdia4 / 554998	ZFINID:	ZDB-GENE-030131-5493	Length:	642	Species:	Danio rerio

Alignment Length:	296	Identity:	66/296 - (22%)
Similarity:	112/296 - (37%)	Gaps:	83/296 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PLTEVDRKSPGGRFTFDGP--KVVAFHFVKNRHGDTLDKWISLLDELAQEYAGRILFGLRDISN- 83
            |..::.||  |..|.::||  |.....::.::.|.. .|.:..|.:: ||.       |||..:
Zfish   250 PTLKIFRK--GKAFDYNGPREKFGIVDYMSDQAGPP-SKQVQTLKQV-QEL-------LRDGDDA 303

  Fly    84 --IGEFNPNLNPDDFGSYRKGLPPRIYGKDCEGRVYD---MHKLVN--AKYLREFCDQ--LLADQ 139
              :|.|    :.|:..:|      .||.:.|.....|   ||...|  .|:|:....|  :|..:
Zfish   304 VIVGVF----SSDEDAAY------EIYQEACNSLREDYKFMHTFNNDVTKFLKASPGQVVMLQPE 358

  Fly   140 LFRAVVLGATASL---DSKP----MNYFEL-------REESSSDM-------LVML--------- 174
            .||:....|:.||   ||.|    .::|:.       ..:.|:|.       ||::
Zfish   359 KFRSKYESASHSLTIKDSTPASEVQDFFKKHILPLVGHRKQSNDAKRYTKRPLVVVYYGVDFSFD 423

  Fly   175 YDPACYYWPIQKRMLRKLIRLLASEDLP---IVIVDK---ANNYLGVGFTRWLQMVNC-----HG 228
            |..|..:|  :.::|.      .::|.|   ..|.|:   |:....:|.:...:.||.     .|
Zfish   424 YRVATQFW--RSKVLE------VAKDFPEYTFAIADEEDYADELKSLGLSESGEEVNVGIVGEGG 480

  Fly   229 STIFTSPRRDGWDIKLSVRMESTRGYLRYIARNRQP 264
            ......|.....|:..|..|...:|.|:.|.:: ||
Zfish   481 KKYAMEPEEFDSDVLRSFVMAFKKGKLKPIVKS-QP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14695	NP_650032.1	Thioredoxin_6	<20..134	CDD:290560	29/121 (24%)
pdia4	NP_956073.2	pdi_dom	64..165	CDD:273454
		ER_PDI_fam	174..640	CDD:273457	66/296 (22%)
		pdi_dom	179..280	CDD:273454	8/31 (26%)
		PDI_b_ERp72	283..389	CDD:239366	31/124 (25%)
		PDI_b'_ERp72_ERp57	394..503	CDD:239371	21/116 (18%)
		PDI_a_PDI_a'_C	523..628	CDD:239293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000